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PCOS Nutrient Support

Protocol overview

Compare your current stack nutrients to the outlined protocol recommendations.

Polycystic Ovary Syndrome (PCOS) is one of the most common and misunderstood endocrine disorders affecting women. Despite the name, PCOS isn’t about cysts. It is rooted in hormone dysfunction. At its core, PCOS is an ovulatory disorder, where the communication between the brain and ovaries becomes disrupted, leading to infrequent or absent ovulation.

When ovulation doesn’t occur, the body doesn’t produce enough progesterone and shifts toward making more androgens like testosterone. This imbalance can cause symptoms such as acne, unwanted hair growth, irregular cycles, and infertility. Many people with PCOS also experience insulin resistance and chronic inflammation, which further impact hormone and metabolic health.

The good news is that there are ways to support your body with intention and precision.

This protocol is designed to support the foundational systems affected by PCOS, including ovulation, insulin sensitivity, hormone balance, and oxidative stress. Inositol supports healthy insulin signaling and promotes regular ovulation. CoQ10, NAC, and omega-3 fatty acids reduce inflammation and oxidative stress, while folic acid and vitamin D help normalize homocysteine levels, improve egg quality, and support hormone function. (For a precise explanation of why folic acid is recommended instead of methylated folate, and additional information relating to the MTHFR gene, please review the Warning section later in the Protocol). Melatonin promotes restorative sleep, which plays a key role in hormone balance and ovarian health.

Whether you are trying to conceive or seeking better hormonal balance, these nutrients support the systems that matter most in PCOS. If your cycles are irregular, your labs show elevated androgens, or your ovaries appear polycystic on ultrasound, this foundational protocol is designed to support ovulation, restore hormone health, and help you feel more in sync with your body.

Last updated: May 13, 2025


7 Nutrients

FA

Folic Acid

400mcg

Folic acid helps lower elevated homocysteine levels often seen in PCOS, which may improve insulin sensitivity and cardiovascular health. It also supports ovulation and reproductive function by promoting DNA synthesis, methylation, and hormone regulation. (For a precise explanation of why folic acid is recommended instead of methylated folate, and additional information relating to the MTHFR gene, please review the Warning section later in the Protocol). [1]

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D3

Vitamin D3

25mcg

Vitamin D supports healthy cell growth, helps regulate immune function and inflammation, and is essential for calcium absorption and bone mineralization. Adequate levels are important during midlife to maintain skeletal strength and support overall metabolic and immune health. [2]

Ω3

Omega-3 fatty acids

300mg

Omega-3 fatty acids may help reduce inflammation, improve insulin sensitivity, and support hormonal balance in women with PCOS. Supplementation has been shown to lower triglycerides, regulate menstrual cycles, and reduce androgen levels, supporting metabolic and reproductive health. [3]

CQ

Coenzyme Q10

200mg

CoQ10 supports mitochondrial function and reduces oxidative stress in women with PCOS. It may improve insulin sensitivity, lower androgen levels, and support ovulation—making it beneficial for metabolic and reproductive health. [4]

In

Inositol

1000mg

Myo-inositol (MI) is important in cell communication and participates in insulin and gonadotropin signaling. MI is an antioxidant that improves insulin sensitivity and menstrual cycle regularity in PCOS. [5]

N-A

N-Acetylcysteine

1000mg

N-acetylcysteine (NAC), a derivative of natural amino acid L-cysteine, is a potent antioxidant that can reduce DNA damage. NAC can improve ovulation in PCOS, pregnancy rates in unexplained infertility, and decreases miscarriage rate. [6]

Me

Melatonin

3mg

Melatonin supports sleep, acts as a powerful antioxidant, and may improve progesterone production and egg quality. However, doses over 3 mg can disrupt brain signaling, making lower,targeted doses safer and more effective for reproductive health. [7]


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Recommended for Folic Acid.
Servings
180.0
Price/serv
$0.25
From
$45.88
Format
tablet
Recommended for Vitamin D3.
Servings
250.0
Price/serv
$0.18
From
$44.00
Format
capsule
Recommended for Omega-3 fatty acids.
Servings
30.0
Price/serv
$0.63
From
$18.95
Format
softgel
Recommended for N-Acetylcysteine.
Servings
60.0
Price/serv
$0.29
From
$17.56
Format
capsule
Recommended for Melatonin.
Servings
180.0
Price/serv
$0.21
From
$37.20
Format
capsule
Recommended for Inositol.
Servings
30.0
Price/serv
$0.73
From
$21.95
Format
capsule
Recommended for Coenzyme Q10.
Servings
60.0
Price/serv
$0.77
From
$46.00
Format
gelcap

Warnings

If you are pregnant or undergoing fertility treatment, consult your medical provider. Use caution with metformin or anticoagulants, as some ingredients may enhance insulin sensitivity or affect blood clotting.

Many new prenatal vitamins have entered the market which have methylated folate instead of folic acid. Methylated folate is a downstream metabolite of folic acid. Although some people may have difficulty metabolizing folic acid (associated with a genetic mutation, MTHFR), it is very important to realize that only folic acid has been shown to prevent NTD (neural tube defects). Although methylated folate has been shown to result in sufficient blood folate levels, no study exists proving that methylated folate prevents neural tube defects or compares methylated folate vs folic acid. No study like this will ever exist because when something clearly prevents a bad outcome, like a birth defect, you would never allow a group of pregnant people to be at risk for this outcome when you could prevent it. I recommend you take at least 400 mcg of folic acid, in the form of folic acid. If you love a prenatal that has methylated folate, take an additional folic acid supplement. Methylated folate may help a small group of people who have problems metabolizing folic acid when they are not pregnant, but if you are trying to conceive, I recommend adding folic acid as well.


Lifestyle Improvements

Polycystic Ovary Syndrome (PCOS) is a complex hormonal condition, but the lifestyle changes you make can have a significant impact on how your body functions. In fact, for many patients, lifestyle interventions are the most powerful tool we have, especially when it comes to restoring ovulation, improving metabolic health, and supporting long-term wellness.

Let’s start with the basics: blood sugar balance. Even if you don’t have insulin resistance now, you may still be at higher risk due to PCOS. Prioritize complex, high-fiber carbohydrates like leafy greens, legumes, and whole grains. Avoid sugary drinks, ultra-processed foods, and excessive refined carbohydrates that can spike insulin and worsen androgen production. It’s not about cutting out all carbs, it’s about choosing the right ones that keep blood sugar stable and support hormone balance.

Focus on protein with every meal. Plant-based sources like lentils, tofu, and quinoa are great. If you eat animal protein focus on high-quality sources. Studies show that increasing servings of vegetable based protein over animal protein improve ovulation - so do not fear your plant based options. Protein helps regulate appetite and stabilize blood sugar. Omega-3 rich foods like salmon, walnuts, and chia seeds are also a great way to support inflammation and hormone signaling.

Movement matters. Exercise improves insulin sensitivity, reduces inflammation, and supports ovulation. If you’re burned out or under-fueled, too much high-intensity training can actually make things worse. A mix of strength training, walking, and restorative movement like yoga or Pilates is ideal. Find what feels good and supports consistency.

Sleep is your hormonal reset button. Aim for 7–9 hours per night, create a calming nighttime routine, and limit blue light before bed. Chronic sleep disruption can raise cortisol and worsen insulin resistance.

Minimize exposure to endocrine disruptors. That means ditch plastic food containers, avoid canned goods with BPA linings, and choose phthalate- and fragrance-free personal care products. These small shifts can reduce chemical exposures that mimic or interfere with hormone signaling.

Finally, be patient with your body. PCOS isn’t something to fix, it’s something to work with. And when we support the systems involved like metabolism, ovulation, inflammation, you can start to see real, lasting change.


Disclaimer

These statements have not been evaluated by the Food and Drug Administration. Any products and informational content displayed on this page are not intended to diagnose, treat, cure, or prevent any disease.

While this Protocol has been created by health experts, it is educational in nature and not a substitute for personalized medical advice. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or take medications.


  1. Asemi, Z., Karamali, M., & Esmaillzadeh, A. (2014). Metabolic response to folate supplementation in overweight women with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial. Molecular Nutrition & Food Research, 58(7), 1465–1473. https://doi.org/10.1002/mnfr.201400033
  2. Holick, M. F. (2007). Vitamin D deficiency. The New England Journal of Medicine, 357(3), 266–281. https://doi.org/10.1056/NEJMra070553
  3. Cussons, A. J., Watts, G. F., Mori, T. A., & Stuckey, B. G. A. (2009). Omega-3 fatty acid supplementation decreases liver fat content in polycystic ovary syndrome: A randomized controlled trial employing proton magnetic resonance spectroscopy. The Journal of Clinical Endocrinology & Metabolism, 94(10), 3842–3848. https://doi.org/10.1210/jc.2009-0660
  4. Bader, S. A., Althanoon, Z. A., & Raoof, H. S. (2022). The metabolic effects of coenzyme Q10 in patients with polycystic ovary syndrome. Research Journal of Pharmacy and Technology, 15(3), 1157–1161. https://doi.org/10.52711/0974-360X.2022.00194
  5. Merviel, P., James, P., Bouée, S., Le Guillou, M., Rince, C., Nachtergaele, C., & Kerlan, V. (2021). Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies. Reproductive Health, 18(1), 13. https://doi.org/10.1186/s12978-021-01073-3
  6. Thakker, D., Raval, A., Patel, I., & Walia, R. (2015). N-acetylcysteine for polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled clinical trials. Obstetrics and Gynecology International, 2015, 817849. https://doi.org/10.1155/2015/817849
  7. Yong W, Ma H, Na M, Gao T, Zhang Y, Hao L, Yu H, Yang H, Deng X. Roles of melatonin in the field of reproductive medicine. Biomed Pharmacother. 2021 Dec;144:112001. doi: 10.1016/j.biopha.2021.112001. Epub 2021 Oct 6. PMID: 34624677