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GLP-1 Support

Protocol overview

Compare your current stack nutrients to the outlined protocol recommendations.

This protocol builds on the Essential Weight Management foundation by targeting GLP-1 (glucagon-like peptide-1), a key gut hormone that regulates appetite, blood sugar, and insulin sensitivity. While GLP-1 medications are effective, the body can also stimulate GLP-1 naturally. This protocol uses clinically studied ingredients to encourage the body’s own GLP-1 production and signaling, helping to improve metabolic health and satiety.

L-glutamine serves as the foundation by supporting gut barrier integrity and stimulating GLP-1 secretion, particularly useful in individuals with blood sugar dysregulation or insulin resistance. Akkermansia muciniphila, a next-generation probiotic, has been shown in research to increase GLP-1 secretion, improve metabolic markers, and strengthen the gut lining. Cinnamon extract complements these effects by supporting insulin sensitivity, balancing blood glucose, and enhancing meal-related GLP-1 response.

This protocol is ideal for individuals seeking sustainable fat loss who may struggle with appetite regulation, cravings, or energy dips. When combined with a protein-rich, fiber-dense diet, strength training, high-quality sleep, and effective stress management, this stack can improve metabolic flexibility, reduce overeating, and promote long-term weight maintenance.

While not a substitute for prescription GLP-1 therapies, this protocol may be especially beneficial for those transitioning off medication or looking to enhance the results of their existing plan. It targets similar metabolic pathways with a food-first, physiology-supportive approach—designed to work with the body rather than override it.

Together, these ingredients offer a comprehensive, evidence-based approach to weight and appetite regulation—targeting gut-brain signaling, improving insulin sensitivity, and reinforcing the physiological systems that drive hunger, metabolism, and energy balance.

Last updated: May 13, 2025

3 Nutrients

L-G

L-Glutamine

5g

L-glutamine may support GLP-1 secretion by nourishing intestinal cells and enhancing gut barrier function. Research suggests it can help regulate glucose metabolism and appetite by stimulating incretin hormones like GLP-1, contributing to improved metabolic health. [1]

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Ak

Akkermansia

100million AFU

Akkermansia muciniphila supports GLP-1 secretion by enhancing gut barrier integrity and modulating mucin production. Its presence is associated with improved insulin sensitivity, reduced inflammation, and greater incretin hormone activity, contributing to healthier glucose metabolism and appetite regulation. [2]

Ci

Cinnamon

300mg

Cinnamon may support GLP-1 activity by enhancing insulin sensitivity and promoting healthy blood sugar regulation. Some studies suggest it can delay gastric emptying and improve glucose metabolism, potentially amplifying the glucose-lowering effects of GLP-1 hormones when used alongside lifestyle or pharmaceutical interventions. [3]

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Recommended for L-Glutamine.
Servings
60.0
Price/serv
$0.65
From
$38.95
Format
scoop
Recommended for Akkermansia.
Servings
30.0
Price/serv
$2.20
From
$66.00
Format
capsule
Recommended for Cinnamon.
Servings
60.0
Price/serv
$0.24
From
$14.67
Format
capsule

Warnings

Not intended for use during pregnancy or breastfeeding. Individuals with diabetes, those taking insulin or blood sugar-lowering medications, GLP-1 medications, or with gastrointestinal conditions should consult a healthcare provider before use to ensure safe and appropriate integration.

Lifestyle Improvements

When it comes to supporting GLP-1 naturally, lifestyle plays a powerful role. This protocol is designed to complement, not replace, the essential habits that regulate appetite, improve insulin sensitivity, and stabilize energy levels throughout the day. Implementing these strategies alongside targeted supplementation can help amplify your results and build long-term metabolic resilience.

Start with Protein and Fiber at Every Meal

What you eat—and when you eat it—directly impacts your gut hormone response. Prioritize protein (30-40g per meal) and fiber-rich foods to naturally stimulate GLP-1, support satiety, and reduce blood sugar fluctuations. Begin meals with protein and vegetables to blunt glucose spikes and promote better glycemic control.

Move After Meals

A simple 10–20 minute walk after eating can dramatically improve post-meal blood sugar levels and insulin sensitivity. This movement also signals your body to activate muscle glucose uptake—supporting metabolic health without intense workouts.

Sleep Is Your Secret Weapon

GLP-1 secretion is closely linked to sleep. Just one night of poor sleep can impair insulin sensitivity and increase hunger hormones the next day. Aim for 7–9 hours per night, stick to a regular sleep schedule, and minimize screen exposure before bed to support hormone balance.

Focus on Stress Reduction

Chronic stress raises cortisol, which can blunt GLP-1 secretion and lead to overeating and insulin resistance. Incorporate daily practices like deep breathing, meditation, nature walks, or journaling, even 10 minutes a day can shift your nervous system and improve metabolic outcomes.

Avoid Endocrine Disruptors

Environmental toxins like BPA and phthalates may interfere with hormone signaling, including GLP-1. Reduce plastic use, opt for filtered water, and store food in glass or stainless steel when possible to limit exposure.

Consistency Is Key

Daily rhythm matters. Try to eat at consistent times, get sunlight exposure in the morning, and move regularly throughout the day. Your metabolism functions best when it’s supported by routine.

When combined with this protocol’s clinically studied ingredients, like cinnamon, L-glutamine, and Akkermansia, these strategies help create a strong, sustainable foundation for appetite control, blood sugar balance, and lasting weight management.

Disclaimer

These statements have not been evaluated by the Food and Drug Administration. Any products and informational content displayed on this page are not intended to diagnose, treat, cure, or prevent any disease.

While this Protocol has been created by health experts, it is educational in nature and not a substitute for personalized medical advice. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or take medications.

  1. Jafari-Vayghan, H., Varshosaz, P., Hajizadeh-Sharafabad, F., Asemi, Z., & Taghizadeh, M. (2020). A comprehensive insight into the effect of glutamine supplementation on metabolic variables in diabetes mellitus: A systematic review. Nutrition & Metabolism, 17(80). https://doi.org/10.1186/s12986-020-00503-6
  2. Cani, P. D., & Knauf, C. (2021). A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion. Cell Metabolism, 33(6), 1073–1075. https://doi.org/10.1016/j.cmet.2021.04.010
  3. Qin, B., Panickar, K. S., & Anderson, R. A. (2010). Cinnamon: Potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. Journal of Diabetes Science and Technology, 4(3), 685–693. https://doi.org/10.1177/193229681000400324