Lanae Mullane, ND’s
Essential Organ Support
Protocol overview
Last updated: Feb 15, 2024
6 Nutrients
Creatine
5g
Creatine supports brain energy by replenishing ATP, aiding mental performance and memory. Studies suggest it may improve cognitive function and reduce mental fatigue by enhancing cellular energy and neurotransmitter activity. [1]
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Log in or sign upSilymarin
450mg
Milk thistle, particularly silymarin, is known for its hepatoprotective properties. It may supports liver function by reducing oxidative stress, stabilizing cell membranes, and promoting regeneration of liver cells. [2]
N-Acetylcysteine
900mg
NAC boosts glutathione, a key antioxidant in lung tissue, and supports detoxification. It may thin mucus, improve lung function, and reduce inflammation in respiratory conditions. [3]
Omega-3 fatty acids
1280mg
Omega-3 fatty acids EPA and DHA support cardiovascular health by lowering triglycerides, reducing inflammation, improving endothelial function. [4]
L-Glutamine
3g
L-glutamine is a key amino acid for maintaining intestinal integrity. It may support mucosal healing, reduce intestinal permeability, and enhance gut barrier function, particularly after stress, injury, or illness. [5]
Lutein
20mg
Lutein is a carotenoid concentrated in the retina that helps filter blue light and protect against oxidative damage. When combined with zeaxanthin, it supports visual acuity and may reduce the risk of age-related macular degeneration. [6]

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Warnings
Do Not Take With: Avoid combining this protocol with anticoagulants or antiplatelet drugs. Do not take NAC with nitroglycerin due to potential hypotensive effects. Use caution combining silymarin with CYP450-metabolized medications, as it may alter their metabolism.
Do Not Take If: You have known allergies to any of the included ingredients or underlying medical conditions such as liver disease, bleeding disorders, or kidney issues without first consulting a qualified healthcare professional.
This protocol is intended to complement, not replace, healthy lifestyle practices.
Lifestyle Improvements
Supporting long-term organ health requires more than just targeted supplements. It depends heavily on foundational lifestyle practices. Research continues to confirm that daily habits such as diet, movement, stress management, and environmental exposures play a profound role in protecting key organs like the liver, brain, heart, and kidneys.
First, limiting or avoiding alcohol is one of the most important steps you can take for liver and brain health. Chronic alcohol use is linked to hepatic inflammation, fatty liver, and cognitive decline. Reducing intake or eliminating it altogether can dramatically reduce liver enzyme elevations and allow for hepatic regeneration over time. Similarly, avoiding recreational drugs and unnecessary medications can reduce toxic burden on the liver and kidneys.
Nutrition plays a critical role. A diet rich in antioxidants, healthy fats, fiber, and essential vitamins helps protect against oxidative stress, which damages cellular membranes in organs like the brain, skin, and heart. Prioritize foods high in polyphenols (berries, olive oil, green tea), fiber (leafy greens, oats, chia seeds), and healthy fats (wild fish, flaxseed, avocado). Reduce added sugars and ultra-processed foods, which have been linked to inflammation, metabolic strain, and impaired gut barrier integrity.
Physical activity supports cardiovascular health, improves insulin sensitivity, and helps reduce liver fat. Aim for at least 150 minutes per week of moderate aerobic exercise, along with resistance training to maintain muscle mass and metabolic health. Movement also improves blood flow to the brain and kidneys and supports lymphatic drainage, which plays a role in detoxification.
Finally, environmental and stress exposures should not be overlooked. Chronic stress elevates cortisol and inflammatory markers, which may compromise immune function, cardiovascular integrity, and neurological resilience. Incorporate stress-reducing habits such as deep breathing, time in nature, meditation, or journaling. Equally important, reduce toxin exposure by choosing clean personal care products, avoiding tobacco smoke, and drinking filtered water when possible.
Together, these daily habits provide the groundwork for protecting and optimizing your organ function. Supplements may act as targeted support, but your daily choices remain the most powerful tool in preserving long-term health.
Disclaimer
These statements have not been evaluated by the Food and Drug Administration. Any products and informational content displayed on this page are not intended to diagnose, treat, cure, or prevent any disease.
While this Protocol has been created by health experts, it is educational in nature and not a substitute for personalized medical advice. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or take medications.
- Avgerinos, K. I., Spyrou, N., Bougioukas, K. I., & Kapogiannis, D. (2018). Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials. Experimental Gerontology, 108, 166–173. https://doi.org/10.1016/j.exger.2018.04.013
- Li, S., Duan, F., Li, S., & Lu, B. (2024). Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis. Annals of Hepatology, 29(2), 101174. https://doi.org/10.1016/j.aohep.2023.101174
- Tian H, Zhou Y, Tang L, Wu F, Deng Z, Lin B, Huang P, Wei S, Zhao D, Zheng J, Zhong N, Ran P. High-dose N-acetylcysteine for long-term, regular treatment of early-stage chronic obstructive pulmonary disease (GOLD I-II): study protocol for a multicenter, double-blinded, parallel-group, randomized controlled trial in China. Trials. 2020 Sep 11;21(1):780. doi: 10.1186/s13063-020-04701-8. PMID: 32917271; PMCID: PMC7488567
- Khan SU, Lone AN, Khan MS, Virani SS, Blumenthal RS, Nasir K, Miller M, Michos ED, Ballantyne CM, Boden WE, Bhatt DL. Effect of omega-3 fatty acids on cardiovascular outcomes: A systematic review and meta-analysis. EClinicalMedicine. 2021 Jul 8;38:100997. doi: 10.1016/j.eclinm.2021.100997. PMID: 34505026; PMCID: PMC8413259
- Abbasi F, Haghighat Lari MM, Khosravi GR, Mansouri E, Payandeh N, Milajerdi A. A systematic review and meta-analysis of clinical trials on the effects of glutamine supplementation on gut permeability in adults. Amino Acids. 2024 Oct 13;56(1):60. doi: 10.1007/s00726-024-03420-7. PMID: 39397201; PMCID: PMC11471693
- Age-Related Eye Disease Study 2 Research Group. (2013). Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: The Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA, 309(19), 2005–2015. https://doi.org/10.1001/jama.2013.4997