Darshan Shah, MD’s
Blood Glucose Support
Protocol overview
Last updated: May 13, 2025
5 Nutrients
Berberine
500mg
Berberine has been studied for its potential role in supporting insulin sensitivity, glucose metabolism, and activation of AMPK, a key enzyme involved in cellular energy balance. It may help maintain healthy blood sugar levels when paired with a balanced diet and lifestyle. [1]
See how your current
nutrient totals stack up
Log in or sign upFiber
5Gram(s)
Dietary fiber can help support blood glucose regulation by slowing digestion and the absorption of carbohydrates. This may promote more stable post-meal glucose levels and support insulin sensitivity. [2]
Alpha-Lipoic Acid
300mg
Alpha-lipoic acid (ALA) plays a role in metabolic function by supporting insulin sensitivity and glucose uptake in cells. It may also help counter oxidative stress associated with blood sugar imbalance, contributing to overall metabolic health. [3]
Akkermansia
100million AFU
Akkermansia muciniphila is a beneficial gut microbe that may influence metabolic health by supporting gut barrier function and maintaining healthy inflammation levels. Research suggests it may help improve insulin sensitivity and contribute to better glucose control through microbiome balance. [4]
Chromium
200mcg
Chromium plays a role in glucose metabolism by supporting insulin action and helping maintain healthy blood sugar levels. It may assist in improving insulin sensitivity, particularly in individuals with impaired glucose tolerance or metabolic challenges. [5]

Make Sense of Supplements
SuppCo is the world’s first app for building your Supplement Stack and meeting real health goals with Expert Protocols.
Download the appProducts
SuppCo does not participate in supplement affiliate programs. The links below are provided solely for your convenience.
Warnings
Do not use if you are pregnant, breastfeeding, or have been diagnosed with liver or kidney disease unless advised by a healthcare provider. Individuals taking blood sugar-lowering medications, including insulin or GLP-1 agonists, should consult their provider before starting to avoid risk of hypoglycemia.
Lifestyle Improvements
Sustainable blood sugar balance begins with consistent lifestyle habits that support metabolic health. This protocol works best when paired with daily routines that regulate glucose, improve insulin sensitivity, and reduce metabolic stress. By making intentional adjustments to your nutrition, movement, sleep, and stress, you can optimize outcomes and promote long-term stability.
-
Eat Balanced, Whole Food Meals Focus on meals centered around protein, healthy fats, and fiber-rich vegetables to reduce blood sugar spikes and promote satiety. Prioritize complex carbohydrates from whole foods like sweet potatoes, legumes, and quinoa, and pair them with protein and fat to slow glucose absorption. Limit added sugars and ultra-processed foods, which can cause rapid blood sugar fluctuations.
-
Maintain a Consistent Eating Schedule Eating at regular intervals helps regulate insulin response and minimizes energy crashes. Avoid skipping meals or going long stretches without food, which may contribute to overeating or erratic blood sugar. Some individuals benefit from a 12-hour overnight fast (e.g., 7 PM to 7 AM), but this should be tailored to personal needs.
-
Move After Meals A short walk after eating—just 10 to 20 minutes—can help reduce postprandial glucose by improving insulin sensitivity and enhancing glucose uptake by muscles. Regular movement throughout the day is key; avoid long periods of sitting when possible.
-
Prioritize Resistance and Aerobic Exercise Aim for at least 3 strength-training sessions per week to increase lean muscle mass, which improves glucose storage and metabolic flexibility. Combine this with moderate aerobic activity like brisk walking, cycling, or swimming 3–5 times per week for cardiovascular and glycemic benefits.
-
Improve Sleep Quality Sleep deprivation impairs glucose metabolism and raises cortisol levels, both of which negatively affect blood sugar. Aim for 7–9 hours of high-quality sleep each night. Establish a calming evening routine, reduce screen time before bed, and maintain a consistent bedtime and wake-up time.
-
Proactively Manage Stress Chronic stress triggers cortisol, which can increase blood sugar and insulin resistance. Incorporate stress-reducing practices such as deep breathing, meditation, time in nature, or cold exposure. Even 10 minutes a day of intentional relaxation can make a measurable difference.
-
Monitor and Adjust Track your progress using tools like a glucometer or continuous glucose monitor (CGM) to better understand how your body responds to different foods, stressors, and lifestyle changes. Use this data to personalize your approach for sustained improvements in blood sugar control.
Disclaimer
These statements have not been evaluated by the Food and Drug Administration. Any products and informational content displayed on this page are not intended to diagnose, treat, cure, or prevent any disease.
While this Protocol has been created by health experts, it is educational in nature and not a substitute for personalized medical advice. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or take medications.
- Xie, W., Su, F., Wang, G., Peng, Z., Xu, Y., Zhang, Y., Xu, N., Hou, K., Hu, Z., Chen, Y., & Chen, R. (2022). Glucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis. Frontiers in Pharmacology, 13, 1015045. https://doi.org/10.3389/fphar.2022.1015045
- Reynolds, A. N., Akerman, A. P., & Mann, J. (2020). Dietary fibre and whole grains in diabetes management: Systematic review and meta-analyses. PLOS Medicine, 17(3), e1003053. https://doi.org/10.1371/journal.pmed.1003053
- Capece, U., Moffa, S., Improta, I., Di Giuseppe, G., Nista, E. C., Cefalo, C. M. A., Cinti, F., Pontecorvi, A., Gasbarrini, A., Giaccari, A., & Mezza, T. (2022). Alpha-lipoic acid and glucose metabolism: A comprehensive update on biochemical and therapeutic features. Nutrients, 15(1), 18. https://doi.org/10.3390/nu15010018
- Depommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., Falony, G., Raes, J., Maiter, D., Delzenne, N. M., de Barsy, M., Loumaye, A., Hermans, M. P., Thissen, J. P., & Cani, P. D. (2019). Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study. Nature Medicine, 25(7), 1096–1103. https://doi.org/10.1038/s41591-019-0495-2
- Zhao, F., Pan, D., Wang, N., Xia, H., Zhang, H., Wang, S., & Sun, G. (2022). Effect of chromium supplementation on blood glucose and lipid levels in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Biological Trace Element Research, 200(2), 516–525. https://doi.org/10.1007/s12011-021-02693-3