Tribulus Terrestris is a plant from the Zygophyllaceae family, widely recognized in traditional medicine systems like Ayurveda and Traditional Chinese Medicine for its potential health benefits. The plant is commonly known as puncture vine, caltrop, or goat's head due to its spiny fruit.
About Tribulus Terrestris
- What is Tribulus Terrestris?
- What is Tribulus Terrestris used for, and what do the studies say?
- How does Tribulus Terrestris work?
- How is Tribulus Terrestris used differently in men’s and women’s health?
- How much Tribulus Terrestris should I take?
- What are the main side effects of Tribulus Terrestris?
- Who should not take Tribulus Terrestris?
- Are Tribulus Terrestris supplements known to interact with any medications?
- What are the best sources of Tribulus Terrestris?
- What forms does Tribulus Terrestris come in?
- Which sub-compounds of Tribulus Terrestris, if any, are critical to the efficacy of Tribulus Terrestris?
- What is Tribulus Terrestris also known as?
- What is important to look for on the label of a Tribulus Terrestris supplement to ensure product quality?
- Disclaimer & References
What is Tribulus Terrestris?
Tribulus Terrestris is a plant from the Zygophyllaceae family, widely recognized in traditional medicine systems like Ayurveda and Traditional Chinese Medicine for its potential health benefits. The plant is commonly known as puncture vine, caltrop, or goat's head due to its spiny fruit. It thrives in dry climates and is native to regions in Southern Europe, Western Asia, and Africa. Over centuries, various parts of the plant, particularly its roots and fruits, have been used for their medicinal properties.
The roots of Tribulus Terrestris are often utilized for enhancing male virility and overall vigor. Historically, they have been reputed to improve libido and sexual well-being without significantly affecting testosterone levels. The fruits of the plant, on the other hand, are known for their potent potential in protecting organ function and general vitality. These fruits contain bioactive compounds, including steroidal saponins like protodioscin, which are thought to contribute to the plant's medicinal effects.
Tribulus Terrestris has gained popularity in contemporary health and wellness circles, particularly as a supplement for boosting athletic performance, enhancing sexual health, and improving overall energy levels. Despite its traditional use and emerging popularity, modern scientific research on the efficacy of Tribulus Terrestris is still developing. Nevertheless, initial studies indicate some promising results, particularly in the areas of sexual health and vitality, making it a subject of ongoing research and interest.
What is Tribulus Terrestris used for, and what do the studies say?
Tribulus Terrestris has been traditionally used for a variety of health benefits, particularly related to enhancing male and female sexual health, improving athletic performance, and boosting overall vitality. Its roots and fruits are rich in bioactive compounds, such as steroidal saponins, flavonoids, and alkaloids, which are believed to contribute to its wide range of effects.
One of the primary uses of Tribulus Terrestris is in supporting male sexual health. Studies have shown that Tribulus Terrestris can modestly improve erectile function in men with mild to moderate erectile dysfunction and partial androgen deficiency. For instance, a study published in the "Journal of Sexual Medicine" demonstrated that a combination of Tribulus Terrestris and Cornus officinalis extracts can enhance smooth muscle relaxation and increase cyclic AMP levels in the corpus cavernosum, potentially improving erectile function. However, other studies have found conflicting results, with some indicating no significant difference compared to placebo in improving erectile dysfunction or testosterone levels.
For women, Tribulus Terrestris has shown promise in improving sexual desire and function, particularly in postmenopausal women. A randomized, double-blind, placebo-controlled trial published in "Menopause" found that Tribulus Terrestris significantly improved sexual function scores and increased free and bioavailable testosterone levels in postmenopausal women with hypoactive sexual desire disorder. Another study in "Gynecological Endocrinology" reported similar findings in premenopausal women, indicating that Tribulus Terrestris could be a safe and effective alternative for treating sexual dysfunction.
In addition to its effects on sexual health, Tribulus Terrestris is also used to enhance athletic performance and general vitality. Some studies suggest that it may improve muscle strength and endurance, although the evidence is not yet conclusive. The plant's potential benefits for organ function and overall health have also been explored, with some research indicating protective effects on the liver and kidneys.
While the initial research is promising, it's important to note that the studies on Tribulus Terrestris are still in their early stages, and more comprehensive research is needed to fully understand its efficacy and safety. Nonetheless, its traditional use and emerging scientific evidence make it a popular supplement for those seeking to improve sexual health, vitality, and overall well-being.
How does Tribulus Terrestris work?
Tribulus Terrestris works through a combination of bioactive compounds that interact with the body in various ways. The primary constituents believed to be responsible for its effects are steroidal saponins, particularly protodioscin, along with flavonoids, alkaloids, and other phytochemicals. These compounds are thought to influence several physiological pathways, contributing to the herb’s reputed benefits.
One of the key mechanisms by which Tribulus Terrestris is believed to work is by influencing the nitric oxide (NO) pathway. Nitric oxide is a crucial molecule in the body that helps to relax blood vessels, thereby improving blood flow. Studies have shown that Tribulus Terrestris can enhance the production of nitric oxide, which in turn promotes smooth muscle relaxation in the corpus cavernosum of the penis. This can help improve erectile function, as observed in studies published in reputable journals like the "Journal of Sexual Medicine" and the "Korean Journal of Urology."
Another important aspect of how Tribulus Terrestris works is its potential effect on sex hormones. Some animal studies have shown that Tribulus Terrestris can increase levels of testosterone, dihydrotestosterone (DHT), and dehydroepiandrosterone sulfate (DHEAS). For instance, research published in "Phytomedicine" indicated that Tribulus Terrestris increased testosterone levels in primates, rabbits, and rats. However, human studies have yielded mixed results, with some showing no significant increase in testosterone levels. The androgenic effects of Tribulus Terrestris are still a subject of ongoing research and debate.
In women, the mechanisms may be somewhat different but are still linked to hormonal modulation. Studies suggest that Tribulus Terrestris can increase levels of free and bioavailable testosterone, which may help improve sexual desire and function. A study in "Menopause" demonstrated that postmenopausal women taking Tribulus Terrestris showed significant improvements in sexual function scores and increased testosterone levels. The exact pathways through which Tribulus Terrestris affects female sexual health are not fully understood but may involve both hormonal and non-hormonal mechanisms.
Additionally, the antioxidant properties of Tribulus Terrestris also play a role in its overall effects. Antioxidants help to neutralize free radicals in the body, reducing oxidative stress and potentially protecting organs such as the liver and kidneys. These protective effects were highlighted in various studies and suggest that Tribulus Terrestris may support general health and vitality beyond its effects on sexual function.
In summary, Tribulus Terrestris works through multiple mechanisms, including the nitric oxide pathway, hormonal modulation, and antioxidant activity. These combined actions contribute to its potential benefits in enhancing sexual health, improving vitality, and protecting organ function.
How is Tribulus Terrestris used differently in men’s and women’s health?
Tribulus Terrestris is utilized in both men's and women's health, but its applications and the specific benefits sought can vary between the sexes due to physiological differences and distinct health concerns. While both men and women may use Tribulus Terrestris for enhancing sexual health and overall vitality, the focus and observed effects can differ.
In men’s health, Tribulus Terrestris is primarily used to support sexual function and vitality. Many men turn to this herbal supplement to potentially improve erectile function, increase libido, and enhance overall sexual performance. Several studies have explored these benefits. For instance, research published in "Phytomedicine" found that Tribulus Terrestris could increase testosterone levels in animal models, although human studies have shown mixed results regarding testosterone enhancement. Nevertheless, the plant's ability to improve erectile function through mechanisms like smooth muscle relaxation and increased nitric oxide production in the corpus cavernosum has been documented in studies such as those in the "Journal of Sexual Medicine."
In addition to sexual health, men may also use Tribulus Terrestris to boost athletic performance and muscle strength. The herb is thought to improve physical endurance and recovery, making it popular among athletes and bodybuilders. The active compounds in Tribulus Terrestris, such as protodioscin, are believed to contribute to these effects by enhancing overall energy levels and possibly influencing muscle protein synthesis.
For women, Tribulus Terrestris is often used to address sexual dysfunction, particularly issues related to libido and arousal. Postmenopausal women, in particular, may experience a decline in sexual desire and function, and Tribulus Terrestris has been studied for its potential to alleviate these symptoms. A study published in "Menopause" found that Tribulus Terrestris significantly improved sexual function scores and increased levels of free and bioavailable testosterone in postmenopausal women. Similarly, research in "Gynecological Endocrinology" showed that premenopausal women with hypoactive sexual desire disorder experienced improvements in sexual function after taking Tribulus Terrestris.
Besides sexual health, women might also use Tribulus Terrestris for its potential benefits on hormonal balance and reproductive health. Some studies suggest that the herb may help improve symptoms of polycystic ovary syndrome (PCOS) and enhance overall reproductive system health. The presence of protodioscin and other steroidal saponins in Tribulus Terrestris is believed to play a role in these effects by modulating hormone levels and improving ovarian function.
In summary, while Tribulus Terrestris is used by both men and women for enhancing sexual health and vitality, the specific benefits and applications can differ. Men primarily use it for improving erectile function, libido, and athletic performance, while women use it to address sexual dysfunction, hormonal balance, and reproductive health. The distinct physiological needs and health concerns of each sex guide the targeted use of Tribulus Terrestris in their respective health regimens.
How much Tribulus Terrestris should I take?
The optimal dosage of Tribulus Terrestris can vary depending on the specific health goals, the form of the supplement, and individual factors like age, weight, and overall health. While there is no universally established dosage, several studies and traditional practices provide some guidance on typical amounts used for various purposes.
For enhancing sexual function and libido, both in men and women, dosages commonly range from 750 mg to 1,500 mg per day of a standardized Tribulus Terrestris extract. For instance, a study published in "Menopause" used a dose of 750 mg per day of Tribulus Terrestris to improve sexual function in postmenopausal women. Another study in "Phytomedicine" involving men with erectile dysfunction used a dosage of 800 mg per day. These studies typically span several weeks to gauge effectiveness and safety.
Athletes and bodybuilders who use Tribulus Terrestris for its potential benefits in enhancing athletic performance and muscle strength often take higher doses. Dosages in this context can range from 1,500 mg to 3,000 mg per day. However, it is crucial to note that higher doses should be approached with caution and ideally under the guidance of a healthcare professional, as the long-term effects and safety of such dosages are not well-established.
For general vitality and organ protection, traditional uses and some studies suggest lower dosages, around 500 mg to 1,000 mg per day. These amounts aim to provide a balanced intake without overstimulating the body, thereby supporting overall health and well-being.
It is essential to consider the form of Tribulus Terrestris being used. The supplement is available in various forms, including capsules, tablets, powders, and teas. Standardized extracts, which are often calibrated to contain a specific percentage of active compounds like saponins, are preferred in clinical studies and provide more consistent dosing. For example, a standardized extract containing 40% saponins might be more potent than a non-standardized product, and thus, the dosage might be adjusted accordingly.
When starting Tribulus Terrestris, it is often recommended to begin with a lower dose to assess individual tolerance and gradually increase if needed. Always follow the dosage instructions provided by the manufacturer and consider consulting with a healthcare professional, especially if you have any pre-existing health conditions or are taking other medications.
In summary, typical dosages of Tribulus Terrestris range from 750 mg to 1,500 mg per day for sexual health and libido enhancement, potentially higher for athletic performance, and around 500 mg to 1,000 mg per day for general vitality. The form of the supplement and individual health factors should guide the exact dosage, and professional guidance is recommended to ensure safety and effectiveness.
What are the main side effects of Tribulus Terrestris?
Tribulus Terrestris is generally considered safe for most people when taken in appropriate dosages. However, like any supplement, it can cause side effects in some individuals. The side effects of Tribulus Terrestris are typically mild and transient, but it is important to be aware of them to make informed decisions about its use.
One of the most commonly reported side effects is gastrointestinal discomfort. Some users experience symptoms such as stomach cramps, nausea, and diarrhea. These issues are generally mild and often subside as the body adjusts to the supplement. Taking Tribulus Terrestris with food can help mitigate these gastrointestinal side effects.
Another potential side effect is hormonal imbalance, particularly in men. While Tribulus Terrestris has been studied for its potential to influence testosterone levels, some individuals may experience fluctuations in hormone levels that could lead to symptoms like mood swings, irritability, or changes in libido. However, it is worth noting that human studies have shown mixed results regarding the supplement's impact on testosterone levels, suggesting that this effect may not be significant for everyone.
Skin reactions are another possible side effect. A small number of users have reported experiencing rashes or itching after taking Tribulus Terrestris. These skin reactions are usually mild and may be an indication of an allergic response to the supplement. If you develop any severe skin reactions or signs of an allergic reaction, such as swelling or difficulty breathing, it is crucial to discontinue use and seek medical attention immediately.
Some studies have also raised concerns about the potential nephrotoxic effects of Tribulus Terrestris. Although these findings are primarily based on animal studies, they suggest that high doses or long-term use of the supplement could potentially affect kidney function. It is advisable for individuals with pre-existing kidney conditions to approach Tribulus Terrestris with caution and consult a healthcare professional before use.
In summary, while Tribulus Terrestris is generally safe for most people, it can cause side effects such as gastrointestinal discomfort, hormonal imbalances, skin reactions, and potential nephrotoxicity. These side effects are usually mild and manageable, but it is essential to monitor your body's response to the supplement and consult with a healthcare professional if you experience any adverse effects or have pre-existing health conditions.
Who should not take Tribulus Terrestris?
While Tribulus Terrestris is generally considered safe for most people, certain individuals should exercise caution or avoid it altogether due to potential risks and contraindications. Understanding who should not take Tribulus Terrestris can help prevent adverse effects and ensure safe usage.
Pregnant and Breastfeeding Women: Tribulus Terrestris is not recommended for pregnant or breastfeeding women due to insufficient evidence regarding its safety in these populations. Some animal studies have suggested potential adverse effects on fetal development, and there is a lack of robust clinical data to confirm its safety during pregnancy and lactation.
Individuals with Hormone-Sensitive Conditions: Because Tribulus Terrestris may influence hormone levels, individuals with hormone-sensitive conditions should avoid using it. This includes those with a history of hormone-sensitive cancers such as breast, ovarian, or prostate cancer. Additionally, individuals with conditions like endometriosis or uterine fibroids should also be cautious, as the supplement's potential hormonal effects could exacerbate these conditions.
People with Pre-Existing Kidney or Liver Conditions: Some studies have raised concerns about the potential nephrotoxic effects of Tribulus Terrestris, particularly at high doses or with long-term use. Therefore, individuals with pre-existing kidney conditions or liver issues should avoid using Tribulus Terrestris or consult a healthcare professional before starting the supplement to ensure it does not exacerbate their condition.
Individuals Taking Certain Medications: Tribulus Terrestris may interact with certain medications, potentially altering their effectiveness or increasing the risk of side effects. For example, it may interact with medications that affect hormone levels, such as hormone replacement therapy or birth control pills. Additionally, it could interact with medications metabolized by the liver's cytochrome P450 enzyme system, altering their metabolism and efficacy. People taking medications for hypertension, diabetes, or other chronic conditions should consult their healthcare provider before using Tribulus Terrestris.
People with Allergies to Tribulus Terrestris or Related Plants: Individuals who have known allergies to Tribulus Terrestris or plants in the Zygophyllaceae family should avoid using the supplement to prevent allergic reactions. Symptoms of an allergic reaction may include rash, itching, swelling, dizziness, or difficulty breathing, and immediate medical attention should be sought if these occur.
In summary, pregnant and breastfeeding women, individuals with hormone-sensitive conditions, those with pre-existing kidney or liver issues, people taking certain medications, and individuals with allergies to Tribulus Terrestris or related plants should avoid using the supplement or consult a healthcare professional before starting it. This ensures the safe and effective use of Tribulus Terrestris, minimizing the risk of adverse effects and interactions.
Are Tribulus Terrestris supplements known to interact with any medications?
Yes, Tribulus Terrestris supplements are known to potentially interact with certain medications, which could alter the effectiveness of the medications or increase the risk of adverse effects. Understanding these potential interactions is crucial for ensuring safety and avoiding unintended health issues.
Hormonal Medications: One of the primary concerns is the interaction with hormonal medications. Tribulus Terrestris is believed to influence hormone levels, particularly testosterone. Therefore, it may interfere with hormone replacement therapies, birth control pills, and medications used to treat hormone-sensitive conditions such as breast or prostate cancer. For instance, it may reduce the effectiveness of oral contraceptives or alter the hormonal balance in individuals undergoing hormone therapy.
Blood Pressure Medications: Tribulus Terrestris may also interact with medications that manage blood pressure. Some studies suggest that the supplement could have an effect on blood pressure, potentially enhancing the effects of antihypertensive drugs. This could result in blood pressure dropping too low, leading to symptoms like dizziness, fainting, or even more serious cardiovascular issues. Individuals taking medications such as beta-blockers, ACE inhibitors, or diuretics should be cautious and consult their healthcare provider before using Tribulus Terrestris.
Diabetes Medications: Tribulus Terrestris has been studied for its potential effects on blood sugar levels. While some findings are promising, suggesting that it might help manage blood glucose, this also means it could interact with diabetes medications like insulin or oral hypoglycemic agents. The combination could lead to hypoglycemia, a condition where blood sugar levels drop too low, causing symptoms such as shakiness, confusion, and in severe cases, loss of consciousness.
Anticoagulants and Antiplatelet Drugs: Another potential interaction is with blood-thinning medications, including anticoagulants like warfarin and antiplatelet drugs like aspirin. Tribulus Terrestris may affect blood clotting, potentially enhancing the effects of these medications and increasing the risk of bleeding or bruising. Individuals on these medications should exercise caution and consult a healthcare professional before starting Tribulus Terrestris.
Medications Metabolized by the Liver: Tribulus Terrestris can affect the liver's enzyme systems, particularly the cytochrome P450 enzyme system, which is responsible for metabolizing many drugs. This interaction can alter the metabolism of medications processed by these enzymes, potentially leading to either increased toxicity or reduced efficacy of the drugs. Medications that fall into this category include certain antidepressants, antipsychotics, and statins used for managing cholesterol levels.
In summary, Tribulus Terrestris supplements can interact with hormonal medications, blood pressure drugs, diabetes medications, anticoagulants, and drugs metabolized by the liver's cytochrome P450 enzyme system. To minimize the risk of adverse interactions, it is essential to consult with a healthcare provider before starting Tribulus Terrestris, especially if you are taking any of these medications. This ensures safe and effective use of the supplement while maintaining the efficacy of your prescribed treatments.
What are the best sources of Tribulus Terrestris?
When choosing a Tribulus Terrestris supplement, it’s important to consider the quality, purity, and potency of the product to ensure you receive the maximum benefits. Here are some of the best sources and key factors to look for in a high-quality Tribulus Terrestris supplement:
Standardized Extracts: One of the best ways to ensure you’re getting a potent and effective supplement is to choose products that use standardized extracts. These extracts are calibrated to contain a specific percentage of active compounds, typically saponins like protodioscin, which are believed to be responsible for the plant's beneficial effects. A common standardization is 40% saponins, which ensures that each dose contains a consistent amount of the active ingredient. Standardized extracts provide a level of quality control and reliability that non-standardized products may lack.
Reputable Brands: Opt for supplements from reputable brands known for their quality control and transparency. Established companies often conduct third-party testing to verify the purity, potency, and safety of their products. Look for brands that provide clear labeling, detailed ingredient lists, and information about the sourcing and processing of the Tribulus Terrestris used in their supplements.
Organic and Non-GMO Options: When possible, choose organic and non-GMO Tribulus Terrestris supplements. Organic products are grown without the use of synthetic pesticides and fertilizers, which can be beneficial for those looking to minimize their exposure to these chemicals. Non-GMO options ensure that the product is free from genetically modified organisms, which some consumers prefer for health and environmental reasons.
Forms of Supplement: Tribulus Terrestris is available in various forms, including capsules, tablets, powders, and liquid extracts. Capsules and tablets are convenient and offer precise dosing, making them a popular choice. Powders can be mixed with liquids or added to smoothies, while liquid extracts may offer faster absorption. Choose the form that best fits your lifestyle and preferences.
Dosage and Concentration: Pay attention to the dosage and concentration of the active ingredients in the supplement. Higher concentrations of saponins and other bioactive compounds can enhance the efficacy of the supplement. However, ensure that the dosage aligns with recommended guidelines to avoid potential side effects from overconsumption.
Customer Reviews and Testimonials: Reading customer reviews and testimonials can provide insights into the effectiveness and quality of different Tribulus Terrestris supplements. Look for feedback from users who have similar health goals or conditions to gauge how well the product might work for you.
Certifications and Quality Seals: Look for certifications and quality seals from reputable organizations, such as NSF International, USP (United States Pharmacopeia), or ConsumerLab. These certifications indicate that the product has been independently tested for quality, purity, and potency.
In summary, the best sources of Tribulus Terrestris are standardized extracts from reputable brands, preferably organic and non-GMO, and available in a form that suits your lifestyle. Pay attention to dosage, concentration, customer reviews, and certifications to ensure you are getting a high-quality product that meets your needs.
What forms does Tribulus Terrestris come in?
Tribulus Terrestris is available in a variety of forms, each offering different advantages depending on personal preferences, convenience, and specific health goals. Understanding the various forms can help you choose the one that best fits your lifestyle and needs. Here are the most common forms of Tribulus Terrestris supplements:
Capsules and Tablets: Capsules and tablets are the most popular and convenient forms of Tribulus Terrestris supplements. They provide a precise dosage of the active ingredients, making it easy to monitor and maintain consistent intake. Capsules are often preferred for their ease of swallowing and quick dissolution, while tablets may sometimes offer extended-release formulations. Both forms are portable, making them suitable for individuals with busy lifestyles.
Powders: Tribulus Terrestris powder is another widely available form, offering flexibility in how it can be consumed. The powder can be mixed with water, juice, or smoothies, making it a versatile option for those who prefer not to take pills. This form allows for easy adjustment of dosage, but it requires measuring, which may be less convenient for some users. Powders can also be added to protein shakes or other dietary supplements, making them a good choice for athletes and bodybuilders.
Liquid Extracts: Liquid extracts of Tribulus Terrestris are typically alcohol-based or glycerin-based tinctures. These extracts are absorbed more quickly by the body compared to capsules or tablets, potentially offering faster effects. Liquid extracts can be taken directly using a dropper or mixed with a beverage. They offer precise dosing through the use of a dropper, which can be particularly beneficial for individuals who need to adjust their dosage incrementally.
Teas and Herbal Infusions: Tribulus Terrestris is also available in the form of teas and herbal infusions. These are typically made by steeping the dried leaves, fruit, or roots of the plant in hot water. Teas and infusions are a traditional method of consumption and can be a soothing way to incorporate the herb into a daily routine. However, the concentration of active ingredients in teas may be lower compared to other forms, and it can be more challenging to ensure consistent dosing.
Topical Applications: Although less common, Tribulus Terrestris is sometimes included in topical creams and ointments. These formulations are primarily aimed at providing localized benefits, such as improving skin health or reducing inflammation. Topical applications are not typically used for the systemic effects that oral supplements provide but can be an adjunct to other therapeutic approaches.
Standardized Extracts: Regardless of the form, it's important to look for standardized extracts, which ensure that each dose contains a consistent amount of active compounds, typically measured as a percentage of saponins like protodioscin. Standardized extracts provide more reliable and predictable results compared to non-standardized products.
In summary, Tribulus Terrestris is available in several forms, including capsules, tablets, powders, liquid extracts, teas, and topical applications. Each form has its own set of advantages, and the best choice depends on your individual preferences, lifestyle, and health goals. Always ensure that the product you choose is of high quality and, if possible, standardized for active ingredients to achieve the best results.
Which sub-compounds of Tribulus Terrestris, if any, are critical to the efficacy of Tribulus Terrestris?
The efficacy of Tribulus Terrestris is attributed to several bioactive compounds present in the plant, with steroidal saponins being the most critical. Among these, protodioscin is often highlighted for its significant role in the herb's medicinal properties. Understanding these sub-compounds can help elucidate how Tribulus Terrestris works and why it is effective in various health applications.
Steroidal Saponins: The primary active constituents of Tribulus Terrestris are steroidal saponins, which are glycosides of steroidal aglycones. These saponins are thought to be responsible for many of the plant's health benefits, including its effects on sexual health, hormone regulation, and athletic performance. Protodioscin is the most researched and significant saponin in Tribulus Terrestris, often standardized in extracts to ensure consistent potency and efficacy.
Protodioscin: Protodioscin is a steroidal saponin that has been extensively studied for its role in enhancing libido, sexual function, and overall vitality. Research suggests that protodioscin may influence the production of nitric oxide, which helps relax blood vessels and improve blood flow, particularly in the corpus cavernosum of the penis. This mechanism is believed to contribute to the herb's efficacy in improving erectile function. Additionally, protodioscin might have a role in modulating hormone levels, although human studies have shown mixed results regarding its effect on testosterone.
Diosgenin: Another important saponin found in Tribulus Terrestris is diosgenin. This compound is a precursor for the synthesis of various steroid hormones and has been studied for its potential to support hormonal balance. Diosgenin may contribute to the overall effects of Tribulus Terrestris on sexual health and vitality by influencing the endocrine system.
Flavonoids: Tribulus Terrestris also contains a variety of flavonoids, which are known for their antioxidant properties. These compounds help neutralize free radicals, reducing oxidative stress and potentially protecting cells from damage. The antioxidant activity of flavonoids in Tribulus Terrestris may contribute to its overall health benefits, including support for cardiovascular health and organ protection.
Alkaloids: The plant contains several alkaloids, including harmine and harmaline, which have been studied for their potential neuroprotective and psychoactive properties. While not as extensively researched as saponins, these alkaloids may add to the plant's overall therapeutic profile, particularly in terms of mood regulation and cognitive function.
Tannins and Phenolic Acids: Tribulus Terrestris also includes tannins and phenolic acids, which possess anti-inflammatory and antimicrobial properties. These compounds may help support immune function and reduce inflammation, complementing the plant's other health benefits.
Furostanol Glycosides: These glycosides, another class of steroidal saponins, have shown promise in improving sexual behavior and increasing serum testosterone levels in animal studies. Furostanol glycosides, along with protodioscin, are often the target of standardization in Tribulus Terrestris extracts to ensure efficacy.
In summary, the critical sub-compounds of Tribulus Terrestris contributing to its efficacy include steroidal saponins like protodioscin and diosgenin, flavonoids, alkaloids, tannins, phenolic acids, and furostanol glycosides. These bioactive compounds work synergistically to provide the plant's various health benefits, from enhancing sexual function and hormone regulation to offering antioxidant and anti-inflammatory effects. When choosing a Tribulus Terrestris supplement, it is beneficial to look for standardized extracts that ensure a consistent and potent concentration of these key compounds.
What is Tribulus Terrestris also known as?
Tribulus Terrestris, widely recognized for its traditional and contemporary health benefits, is known by several other names, common misspellings, abbreviations, and chemical compounds. Understanding these different terms can help you identify the plant in various contexts and ensure you are selecting the correct supplement.
Common Names: Tribulus Terrestris is often referred to by several common names, including:
- Puncture Vine
- Caltrop
- Goat’s Head
- Devil’s Weed
- Tackweed
- Bindii
These names typically describe the plant’s physical characteristics, such as its spiny fruits that can puncture tires or its weed-like growth habit.
Scientific Names: While Tribulus Terrestris is the primary scientific name, it is sometimes included in scientific discussions under related species or subspecies. However, Tribulus Terrestris is the most commonly used and studied species within the genus Tribulus.
Common Misspellings: Tribulus Terrestris can sometimes be misspelled in various ways, including:
- Tribulus Terrestis (missing the second "r" in Terrestris)
- Tribulus Terrestus (incorrect vowel substitution)
- Tribulus Terestris (missing one "r" in Terrestris)
- Tribulus Terresstris (extra "s")
- Tribulis Terrestris (incorrect vowel substitution in Tribulus)
Abbreviations: In scientific literature and supplement labels, Tribulus Terrestris may be abbreviated as:
- TT
- T. Terrestris
These abbreviations help streamline the text, particularly in research papers and product descriptions.
Chemical Compounds and Ingredients: Several bioactive compounds within Tribulus Terrestris contribute to its therapeutic effects. The primary compounds include:
- Protodioscin: A steroidal saponin often standardized in extracts for its role in enhancing sexual health and vitality.
- Diosgenin: Another steroidal saponin that serves as a precursor for steroid hormone synthesis.
- Furostanol Glycosides: A class of saponins that have shown promise in improving sexual behavior and increasing testosterone levels in animal studies.
- Flavonoids: Antioxidant compounds that help neutralize free radicals and reduce oxidative stress.
- Alkaloids: Including harmine and harmaline, these compounds may have neuroprotective and psychoactive properties.
- Tannins: Known for their anti-inflammatory and antimicrobial properties.
- Phenolic Acids: Compounds that also contribute to the plant’s antioxidant and anti-inflammatory effects.
Other Ingredients: In some formulations, Tribulus Terrestris supplements may be combined with other herbal ingredients to enhance their effects. Common combinations include:
- Panax Ginseng: Often combined for its adaptogenic and libido-enhancing properties.
- Maca Root: Used to boost energy, stamina, and sexual function.
- Ashwagandha: Included for its stress-reducing and adaptogenic benefits.
In summary, Tribulus Terrestris is also known by various common names, scientific terms, and abbreviations. The key bioactive compounds include protodioscin, diosgenin, furostanol glycosides, flavonoids, alkaloids, tannins, and phenolic acids. Being aware of these names and compounds can help ensure you select the right product and understand its full range of benefits.
What is important to look for on the label of a Tribulus Terrestris supplement to ensure product quality?
When selecting a Tribulus Terrestris supplement, it's crucial to scrutinize the label to ensure you are purchasing a high-quality product. Here are key factors to look for on the label:
Standardized Extracts: One of the most critical aspects to check is whether the supplement uses a standardized extract. Standardization ensures that the product contains a consistent amount of active compounds, typically measured as a percentage of saponins like protodioscin. Look for labels that specify the percentage of saponins, such as “standardized to 40% saponins.” This guarantees potency and effectiveness.
Active Ingredients: The label should clearly list the active ingredients, including the specific compounds and their concentrations. Protodioscin is often highlighted due to its significant role in the herb’s medicinal effects. Ensure that the amount of these active compounds is adequate to provide the desired benefits.
Dosage Information: The recommended dosage should be clearly stated on the label. This includes the amount of Tribulus Terrestris per serving and the number of servings per day. Following the suggested dosage helps ensure safe and effective use of the supplement.
Purity and Additives: Check for any additional ingredients or fillers. High-quality supplements should have minimal additives and should avoid artificial colors, flavors, and preservatives. Look for labels that state the product is free from common allergens such as gluten, soy, and dairy, if these are relevant to your dietary needs.
Quality Certifications: Look for quality certifications and seals from reputable organizations. Certifications from NSF International, USP (United States Pharmacopeia), or ConsumerLab indicate that the product has undergone rigorous testing for quality, purity, and potency. These certifications provide an added layer of assurance that the supplement meets high standards.
Manufacturing Practices: Ensure that the supplement is manufactured in facilities that follow Good Manufacturing Practices (GMP). GMP certification indicates that the product is produced under stringent quality control measures that ensure consistency, safety, and efficacy.
Third-Party Testing: Products that have been independently tested by third-party laboratories are generally more reliable. Look for labels that mention third-party testing, as this indicates that an unbiased organization has verified the product’s quality and purity.
Organic and Non-GMO Labels: If you prefer products that are free from synthetic pesticides and genetically modified organisms, look for organic and non-GMO certifications. These labels ensure that the product adheres to specific agricultural and production standards.
Expiration Date: Check the expiration date to ensure the product is fresh and will remain effective for the duration of its use. Supplements can lose potency over time, so it’s important to choose a product with a reasonable shelf life.
Manufacturer Information: Reliable products should include the name and contact information of the manufacturer. This allows you to reach out with any questions or concerns and provides transparency regarding the product’s origin.
User Reviews and Testimonials: While not on the label, researching user reviews and testimonials can provide insights into the product’s effectiveness and any potential issues. This can complement the information on the label and help you make an informed decision.
In summary, when evaluating a Tribulus Terrestris supplement, look for standardized extracts, clearly listed active ingredients, dosage information, purity, quality certifications, GMP compliance, third-party testing, organic and non-GMO labels, expiration dates, and detailed manufacturer information. These factors collectively ensure that you are selecting a high-quality, effective, and safe supplement.
Disclaimer & References
The information provided on this website, including any text, images, or other material contained within, is for informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. This page was created by the SuppCo editiorial team, with AI summarization tools, including data from but not limited to following studies:
- M. Roaiah, Yasser Ibrahim El Khayat, S. G. GamalEl Din, M. A. Abd El Salam (2016). Pilot Study on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Erectile Function in Aging Males With Partial Androgen Deficiency (PADAM). Journal of Sex & Marital Therapy, 42, 297 - 301. Link: 10.1080/0092623X.2015.1033579
- C. Santos, L. Reis, R. Destro-Saade, A. Luiza-Reis, A. Fregonesi (2014). Tribulus terrestris versus placebo in the treatment of erectile dysfunction: A prospective, randomized, double-blind study. Actas Urologicas Espanolas, 38, 244-248. Link: 10.1016/J.ACUROE.2014.03.009
- V. Neychev, V. Mitev (2016). Pro-sexual and androgen enhancing effects of Tribulus terrestris L.: Fact or Fiction.. Journal of ethnopharmacology, 179,
345-55 . Link: 10.1016/j.jep.2015.12.055 - C. Santos, L. Reis, R. Destro-Saade, A. Luiza-Reis, A. Fregonesi (2014). Tribulus terrestris versus placebo in the treatment of erectile dysfunction: A prospective, randomized, double blind study.. Actas urologicas espanolas, 38 4,
244-8 . Link: 10.1016/j.acuro.2013.09.014 - M. Mahboubi (2019). Tribulus terrestris in Management of Sexual Functions. The Natural Products Journal, , . Link: 10.2174/2210315508666181022125243
- A. Ghanbari, N. Akhshi, S. E. Nedaei, A. Mollica, I. Aneva, Yaping Qi, P. Liao, S. Darakhshan, M. Farzaei, Jianbo Xiao, J. Echeverría (2021). Tribulus terrestris and female reproductive system health: A comprehensive review.. Phytomedicine : international journal of phytotherapy and phytopharmacology, ,
153462 . Link: 10.1016/j.phymed.2021.153462 - J. Do, S. Choi, J. Choi, J. Hyun (2013). Effects and Mechanism of Action of a Tribulus terrestris Extract on Penile Erection. Korean Journal of Urology, 54, 183 - 188. Link: 10.4111/kju.2013.54.3.183
- Z. Kamenov, Svetlana Fileva, K. Kalinov, E. Jannini (2015). Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trial.. Maturitas, 99,
20-26 . Link: 10.1016/j.maturitas.2017.01.011 - K. Gauthaman, Adaikan P Ganesan (2008). The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction--an evaluation using primates, rabbit and rat.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 15 1-2,
44-54 . Link: 10.1016/J.PHYMED.2007.11.011 - S. Kam, J. Do, J. Choi, B. Jeon, G. Roh, J. Hyun (2012). In vivo and in vitro animal investigation of the effect of a mixture of herbal extracts from Tribulus terrestris and Cornus officinalis on penile erection.. The journal of sexual medicine, 9 10,
2544-51 . Link: 10.1111/j.1743-6109.2012.02889.x - A. Kirtishanti, D. Wulansari, Dini Kesuma, I. Gusti, Ayu Laksmi, Dwi Putri, Amirah Nabila Rahmadinar (2023). Herbal Medicine Used to Increase the Libido of Male Mice (Mus musculus): Tribulus terrestris and Panax ginseng. JURNAL ILMU KEFARMASIAN INDONESIA, , . Link: 10.35814/jifi.v21i2.1485
- Ruxandra Ștefănescu, A. Tero-Vescan, Ancuța Negroiu, Elena Aurică, C. Vari (2020). A Comprehensive Review of the Phytochemical, Pharmacological, and Toxicological Properties of Tribulus terrestris L.. Biomolecules, 10, . Link: 10.3390/biom10050752
- Karla Zanolla Dias de Souza, F. Vale, S. Geber (2016). Efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women: a randomized, double-blinded, placebo-controlled trial. Menopause, 23, 1252–1256. Link: 10.1097/GME.0000000000000766
- F. Vale, Karla Zanolla Dias de Souza, C. Rezende, S. Geber (2018). Efficacy of Tribulus Terrestris for the treatment of premenopausal women with hypoactive sexual desire disorder: a randomized double-blinded, placebo-controlled trial. Gynecological Endocrinology, 34, 442 - 445. Link: 10.1080/09513590.2017.1409711
- I. Kostova, D. Dinchev (2005). Saponins in Tribulus terrestris – Chemistry and Bioactivity. Phytochemistry Reviews, 4, 111-137. Link: 10.1007/s11101-005-2833-x
- A. Russo, E. Maisto, L. Romis, G. Celentano (2016). Use of a Natural Compound Made of Ecklonia bicyclis Seaweed, Tribulus terrestris and Water-Soluble Chitosan Oligosaccharide, in Male Sexual Asthenia with Mild or Mild-Moderate Erectile Dysfunction and Serum Testosterone Levels at the Lower Limit of Normal. Health, 08, 1668-1678. Link: 10.4236/HEALTH.2016.815162
- E. Parsaei, A. Esfandiari, A. Dehghan (2015). Survey the Tribulus Terrestris Effects on Histomorphometrical Changes of the Testis Induced by Ethanol Administration in Male Wistar Rat. Journal of Rafsanjan University of Medical Sciences, 13, 765-774. Link:
- V. Neychev, V. Mitev (2016). Pro-sexual and androgen enhancing effects of Tribulus terrestris L.: Fact or Fiction.. Journal of ethnopharmacology, 179,
345-55 . Link: 10.1016/j.jep.2015.12.055 - Sima Sanagoo, Behnaz Sadeghzadeh Oskouei, Nafiseh Gassab Abdollahi, H. Salehi-pourmehr, N. Hazhir, A. Farshbaf‐Khalili (2019). Effect of Tribulus terrestris L. on sperm parameters in men with idiopathic infertility: A systematic review.. Complementary therapies in medicine, 42,
95-103 . Link: 10.1016/j.ctim.2018.09.015 - A. Ghanbari, N. Akhshi, S. E. Nedaei, A. Mollica, I. Aneva, Yaping Qi, P. Liao, S. Darakhshan, M. Farzaei, Jianbo Xiao, J. Echeverría (2021). Tribulus terrestris and female reproductive system health: A comprehensive review.. Phytomedicine : international journal of phytotherapy and phytopharmacology, ,
153462 . Link: 10.1016/j.phymed.2021.153462 - Mohammed Azeemuddin Mukhram, M. Rafiq, Neeraj Kumar, A. Jadhav, S. D. Anturlikar, R. Sundaram, U. Babu, Rangesh Paramesh (2019). Sexual Behaviour in Male Healthy Rats: A Comparison Between Indian Tribulus terrestris Linn. Extracts with Protodioscin Standardized Bulgarian Extract. The Natural Products Journal, , . Link: 10.2174/2210315508666180810144454
- K. Gauthaman, P. Adaikan, R. Prasad (2002). Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats.. Life sciences, 71 12,
1385-96 . Link: 10.1016/S0024-3205(02)01858-1 - F. Vale, Júnia Dueli Boroni, G. Geber, Enylda Motta Gonçalves Antunes, T. Bretas, G. P. Lopes, S. Geber (2021). Effect of Tribulus Terrestris in the Treatment of Female Sexual Dysfunction and Clitoral Vascularization. Results of a Randomized Study Comparing Two Different Dosage Regimes. Journal of Sex & Marital Therapy, 47, 696 - 706. Link: 10.1080/0092623X.2021.1938764
- S. Postigo, S. Lima, S. S. Yamada, B. Reis, G. Silva, T. Aoki (2016). Assessment of the Effects of Tribulus Terrestris on Sexual Function of Menopausal Women. RBGO Gynecology and Obstetrics, 38, 140 - 146. Link: 10.1055/s-0036-1571472
- A. Martimbianco, R. Pacheco, F. Vilarino, Carolina de Oliveira Cruz Latorraca, M. Torloni, R. Riera (2020). Tribulus Terrestris for Female Sexual Dysfunction: A Systematic Review. RBGO Gynecology & Obstetrics, 42, 427 - 435. Link: 10.1055/s-0040-1712123
- Z. Kamenov, Svetlana Fileva, K. Kalinov, E. Jannini (2015). Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trial.. Maturitas, 99,
20-26 . Link: 10.1016/j.maturitas.2017.01.011 - M. Mahboubi (2019). Tribulus terrestris in Management of Sexual Functions. The Natural Products Journal, , . Link: 10.2174/2210315508666181022125243
- V. Neychev, V. Mitev (2016). Pro-sexual and androgen enhancing effects of Tribulus terrestris L.: Fact or Fiction.. Journal of ethnopharmacology, 179,
345-55 . Link: 10.1016/j.jep.2015.12.055 - R. Tyagi, Urmila Aswar, V. Mohan, S. Bodhankar, G. Zambare, P. Thakurdesai (2008). Study of Furostenol Glycoside Fraction of Tribulus terresteris. on Male Sexual Function in Rats. Pharmaceutical Biology, 46, 191 - 198. Link: 10.1080/13880200701735502
- K. Gauthaman, Adaikan P Ganesan, R.N.V. Prasad (2003). Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model.. Journal of alternative and complementary medicine, 9 2,
257-65 . Link: 10.1089/10755530360623374
These statements have not been evaluated by the Food and Drug Administration. Any products and informational content displayed on this page are not intended to diagnose, treat, cure, or prevent any disease.