RR

Rhodiola Rosea is a perennial herbaceous plant that thrives in the harsh climates of high-altitude regions in Europe, Asia, and North America. Known colloquially as "golden root" or "roseroot," this resilient plant has been utilized for centuries in traditional medicine, particularly in Russian and Scandinavian cultures.



What is Rhodiola Rosea?

Rhodiola Rosea is a perennial herbaceous plant that thrives in the harsh climates of high-altitude regions in Europe, Asia, and North America. Known colloquially as "golden root" or "roseroot," this resilient plant has been utilized for centuries in traditional medicine, particularly in Russian and Scandinavian cultures. The roots of Rhodiola Rosea are the primary part used for medicinal purposes, owing to their rich content of bioactive compounds.

The plant belongs to the Crassulaceae family and is distinguished by its yellowish flowers and thick, fleshy roots. These roots are known to contain a variety of phytochemicals, including rosavins, salidroside, and p-tyrosol, which are believed to contribute to its health-promoting properties. The adaptogenic qualities of Rhodiola Rosea make it particularly valuable; adaptogens are natural substances that help the body adapt to stress and exert a normalizing effect upon bodily processes.

Modern research has brought Rhodiola Rosea into the spotlight for its potential benefits in combating fatigue, enhancing physical and mental performance, and reducing symptoms of stress and anxiety. The roots are typically dried and processed into various forms such as capsules, tablets, and extracts, making it accessible for contemporary use. Given its historical and cultural significance, coupled with emerging scientific validation, Rhodiola Rosea continues to garner interest as a natural remedy for improving overall well-being.

Back to table of contents


What is Rhodiola Rosea used for, and what do the studies say?

Rhodiola Rosea is widely used for its adaptogenic properties, which help the body resist the physical, chemical, and biological stressors that can lead to fatigue and mental exhaustion. One of the primary uses of Rhodiola Rosea is to combat fatigue, particularly in situations of chronic stress or during periods of intense physical or mental exertion. Studies have demonstrated that Rhodiola Rosea can significantly reduce fatigue and improve overall well-being. For instance, a study involving foreign students during stressful examination periods found that Rhodiola Rosea extract significantly improved physical fitness, mental fatigue, and general well-being (Spasov et al., 2000).

Aside from its anti-fatigue effects, Rhodiola Rosea has also shown promise in improving cognitive function, particularly in reducing anxiety and enhancing mood. A randomized trial with mildly anxious participants revealed that supplementation with Rhodiola Rosea extract led to significant reductions in self-reported anxiety, stress, anger, and depression, as well as improvements in overall mood (Cropley et al., 2015). These findings are supported by animal studies, which suggest that Rhodiola Rosea’s active compounds, such as salidroside, have anxiolytic and antidepressant properties (Palmeri et al., 2016).

Moreover, Rhodiola Rosea is utilized to enhance physical performance, particularly in endurance exercises. Some studies suggest that it can improve time to exhaustion and reduce perceived exertion during physical activities. For example, acute intake of Rhodiola Rosea was shown to improve endurance exercise capacity in young healthy volunteers by increasing time to exhaustion and reducing the perception of effort (De Bock et al., 2004). However, more research is needed to confirm these benefits, as some studies have reported mixed results.

Overall, while the evidence supports the use of Rhodiola Rosea for reducing fatigue, improving mood, and potentially enhancing physical performance, further research is necessary to fully understand its mechanisms and to establish standardized dosing guidelines.

Back to table of contents


How does Rhodiola Rosea work?

Rhodiola Rosea's adaptogenic properties are primarily attributed to its bioactive compounds, including rosavins, salidroside, and p-tyrosol. These compounds interact with various physiological pathways to enhance the body's resilience to stress and improve overall function. Although the exact mechanisms are not completely understood, several key processes have been identified.

Firstly, Rhodiola Rosea appears to modulate the hypothalamic-pituitary-adrenal (HPA) axis, which plays a central role in the body's response to stress. By influencing the release of stress hormones such as cortisol, Rhodiola Rosea helps to normalize the stress response, reducing the physical and psychological impacts of stress. A study on mice demonstrated that Rhodiola Rosea extract could significantly lower corticosterone levels, a primary stress hormone, following acute stress (Dinel et al., 2019).

Secondly, Rhodiola Rosea exerts neuroprotective effects by enhancing neuronal resilience and plasticity. It has been shown to increase levels of brain-derived neurotrophic factor (BDNF), which supports neuron growth and synaptic plasticity, thereby improving cognitive function and mood. Additionally, Rhodiola Rosea's antioxidant properties help to protect neurons from oxidative stress, which is often elevated during periods of high mental and physical stress (Agapouda et al., 2022).

Moreover, Rhodiola Rosea influences the balance of neurotransmitters in the brain, including serotonin, dopamine, and norepinephrine. These neurotransmitters are crucial for regulating mood, energy, and alertness. By modulating their levels, Rhodiola Rosea can improve symptoms of depression and anxiety. For instance, studies have shown that Rhodiola Rosea can increase serotonin levels in the hippocampus, which is associated with improved mood and reduced depressive symptoms (Chen et al., 2009).

In summary, Rhodiola Rosea works through a combination of hormonal regulation, neuroprotection, and neurotransmitter modulation. These mechanisms collectively enhance the body's ability to cope with stress, improve cognitive function, and elevate mood, making Rhodiola Rosea a valuable adaptogen for overall mental and physical well-being.

Back to table of contents


How is Rhodiola Rosea used differently in men’s and women’s health?

Rhodiola Rosea can be beneficial for both men and women, but there are certain health aspects where its effects may be particularly relevant to each gender due to physiological and hormonal differences. Understanding these distinctions can help in tailoring its use to maximize benefits for men’s and women’s health.

For men, Rhodiola Rosea is often utilized to enhance physical performance and endurance. Studies have indicated that this adaptogen can improve time to exhaustion and reduce perceived exertion during physical activities, which is particularly valuable for athletes and those engaged in strenuous physical work. Additionally, Rhodiola Rosea has been noted for its potential benefits in managing stress-related conditions, such as burnout and fatigue, which are common in high-stress professions. It may also support mental clarity and focus, enhancing cognitive performance during intense mental tasks (De Bock et al., 2004).

In women, Rhodiola Rosea’s adaptogenic properties can be particularly beneficial for managing the physiological and psychological stresses associated with hormonal fluctuations. For instance, Rhodiola Rosea has been studied for its role in alleviating symptoms of menopause, such as fatigue, mood swings, and cognitive decline. Its ability to modulate the HPA axis and reduce cortisol levels can help balance stress hormones, which is crucial during the menopausal transition. Furthermore, Rhodiola Rosea may support emotional well-being and reduce symptoms of anxiety and depression, which are more prevalent in women, particularly during periods of hormonal change (Gerbarg & Brown, 2016).

Both men and women can benefit from Rhodiola Rosea’s effects on mood, stress reduction, and cognitive function. However, the specific applications and observed benefits might differ slightly due to gender-specific health concerns. For example, in a study involving women with symptoms of chronic stress, Rhodiola Rosea supplementation led to significant improvements in mood, concentration, and overall well-being (Edwards et al., 2012). Meanwhile, men might more frequently use Rhodiola Rosea to enhance physical performance and manage work-related stressors.

In summary, while Rhodiola Rosea is beneficial for both men and women, its applications can be tailored to address gender-specific health concerns. Men might focus on its physical performance and stress management benefits, whereas women might leverage its ability to mitigate hormonal fluctuations and support emotional well-being.

Back to table of contents


How much Rhodiola Rosea should I take?

The appropriate dosage of Rhodiola Rosea can vary depending on the specific health goals and the form of the supplement being used. In general, most studies and clinical trials have used doses ranging from 200 to 600 mg per day of standardized Rhodiola Rosea extract, typically containing around 3% rosavins and 1% salidroside, which are considered the primary active compounds.

For managing stress and improving mood, a common dosage is 200 to 400 mg per day. For example, a study investigating the effects of Rhodiola Rosea on individuals with life-stress symptoms used a dosage of 200 mg twice daily for four weeks, resulting in significant improvements in stress symptoms and overall well-being (Edwards et al., 2012). This dosage appears to be both effective and well-tolerated, providing a good starting point for most users.

When aiming to enhance physical performance and reduce fatigue, higher doses might be more effective. Some studies have used doses up to 600 mg per day. For instance, a study on athletes found that a dose of 600 mg daily improved endurance performance and reduced perceived exertion (De Bock et al., 2004). However, it is advisable to start with a lower dose and gradually increase it to assess tolerance and effectiveness.

It is important to note that while higher doses may be beneficial for some individuals, taking more than the recommended amount does not necessarily lead to better results and could increase the risk of side effects. Therefore, adhering to the guidelines provided by clinical studies and product labels is essential.

As with any supplement, it is crucial to consult with a healthcare professional before starting Rhodiola Rosea, especially if you have underlying health conditions or are taking other medications. They can provide personalized advice on the appropriate dosage based on your specific health needs and circumstances.

Back to table of contents


What are the main side effects of Rhodiola Rosea?

Rhodiola Rosea is generally well-tolerated by most people, but like any supplement, it can cause side effects in some individuals. The side effects are typically mild and transient, but it's still important to be aware of them, especially if you're considering taking this adaptogen for the first time.

One of the most commonly reported side effects of Rhodiola Rosea is gastrointestinal discomfort. This can include symptoms such as nausea, dry mouth, and upset stomach. These symptoms are usually mild and tend to resolve on their own as the body adjusts to the supplement. Taking Rhodiola Rosea with food can help minimize these gastrointestinal issues.

Some individuals may also experience dizziness or headaches when taking Rhodiola Rosea. These side effects are generally mild and may diminish over time. If dizziness or headaches persist, it might be beneficial to lower the dosage or discontinue use and consult a healthcare professional for further guidance.

In rare cases, Rhodiola Rosea can cause feelings of jitteriness or restlessness, particularly when taken in high doses. This is due to its stimulating properties, which can affect some individuals more sensitively than others. To avoid this, it is advisable to start with a lower dose and gradually increase it if needed, monitoring how your body responds.

Another aspect to consider is the potential for allergic reactions, although these are rare. Symptoms of an allergic reaction may include rash, itching, swelling, severe dizziness, or trouble breathing. If you experience any of these symptoms, it is crucial to seek medical attention immediately.

Overall, while Rhodiola Rosea is considered safe for most people, it's important to start with a lower dose to gauge your body's response and to consult with a healthcare professional if you have any concerns or pre-existing conditions. Monitoring for any adverse effects and adjusting the dosage accordingly can help ensure a positive experience with this adaptogenic supplement.

Back to table of contents


Who should not take Rhodiola Rosea?

While Rhodiola Rosea is generally considered safe for most individuals, there are certain populations that should exercise caution or avoid using this supplement altogether. Understanding who should not take Rhodiola Rosea can help mitigate potential risks and ensure its safe use.

Firstly, individuals with bipolar disorder or other mood disorders characterized by manic episodes should avoid Rhodiola Rosea. Due to its stimulating properties, Rhodiola Rosea has the potential to trigger manic or hypomanic episodes in susceptible individuals. The herb's ability to enhance mood and energy levels might exacerbate these conditions, leading to increased agitation or restlessness.

Pregnant and breastfeeding women should also refrain from using Rhodiola Rosea, as there is insufficient research on its safety in these populations. Although Rhodiola Rosea has been used traditionally, the lack of well-controlled studies means that its effects on fetal development and breast milk are unknown. It is always best to err on the side of caution and avoid any potential risks to the mother and baby during these critical periods.

People with autoimmune conditions, such as rheumatoid arthritis, lupus, or multiple sclerosis, should consult a healthcare professional before taking Rhodiola Rosea. Some adaptogens can stimulate the immune system, potentially worsening autoimmune symptoms. While there is no direct evidence linking Rhodiola Rosea to adverse effects in autoimmune conditions, it's prudent to seek medical advice given the herb's immune-modulating properties.

Additionally, individuals on certain medications should be cautious. Rhodiola Rosea can interact with antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), and other medications that affect serotonin levels, potentially leading to serotonin syndrome, a serious condition characterized by high levels of serotonin in the brain. If you are taking any prescription medications, it is essential to consult with your healthcare provider to determine if Rhodiola Rosea is appropriate for you.

Lastly, individuals with low blood pressure should be aware that Rhodiola Rosea might further lower blood pressure, potentially causing symptoms like dizziness or fainting. If you have a history of hypotension, it's important to monitor your blood pressure closely and discuss the use of Rhodiola Rosea with your healthcare provider.

In summary, while Rhodiola Rosea is beneficial for many, individuals with certain health conditions, those who are pregnant or breastfeeding, and those on specific medications should avoid its use or seek medical advice prior to supplementation. This ensures safety and helps avoid any potential adverse effects.

Back to table of contents


Are Rhodiola Rosea supplements known to interact with any medications?

Yes, Rhodiola Rosea supplements can potentially interact with certain medications, which is why it is essential to consult a healthcare professional before starting supplementation, especially if you are on prescription medications. Here are some key interactions to be aware of:

  1. Antidepressants: Rhodiola Rosea may interact with antidepressant medications, particularly selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs). Both Rhodiola Rosea and these medications can increase serotonin levels in the brain, which could potentially lead to serotonin syndrome. This is a serious condition characterized by symptoms such as agitation, confusion, rapid heart rate, and high blood pressure. If you are taking antidepressants, it is crucial to consult your healthcare provider before using Rhodiola Rosea.
  2. Stimulants: Rhodiola Rosea has stimulating properties, which means it could enhance the effects of stimulant medications, such as those used for attention deficit hyperactivity disorder (ADHD) or certain weight loss drugs. This could lead to increased heart rate, elevated blood pressure, and excessive nervousness or jitteriness. Combining Rhodiola Rosea with stimulants should be done cautiously and under the guidance of a healthcare professional.
  3. Blood Pressure Medications: Rhodiola Rosea may have blood pressure-lowering effects, which could potentially enhance the effects of antihypertensive medications. This might lead to an excessive drop in blood pressure, causing symptoms such as dizziness, fainting, or lightheadedness. If you are taking medication for high blood pressure, it's important to monitor your blood pressure closely and discuss the use of Rhodiola Rosea with your healthcare provider.
  4. Blood Thinners: There is limited evidence, but some experts suggest that Rhodiola Rosea might affect blood clotting. If you are on blood-thinning medications, such as warfarin or aspirin, taking Rhodiola Rosea could potentially increase the risk of bleeding. It is advisable to consult your healthcare provider before using Rhodiola Rosea if you are on anticoagulant therapy.
  5. Immunosuppressants: Rhodiola Rosea has immune-modulating effects, which means it could potentially interfere with immunosuppressive drugs used to prevent organ transplant rejection or to treat autoimmune diseases. This interaction could alter the effectiveness of immunosuppressive therapy, so it is important to seek medical advice before combining these treatments.

Overall, while Rhodiola Rosea is generally safe for many individuals, its potential interactions with certain medications underscore the importance of consulting a healthcare professional before starting supplementation. This ensures that you can safely incorporate Rhodiola Rosea into your regimen without risking adverse interactions with your current medications.

Back to table of contents


What are the best sources of Rhodiola Rosea?

When seeking Rhodiola Rosea supplements, it is crucial to prioritize quality and purity to ensure you receive the full benefits of this adaptogenic herb. The best sources of Rhodiola Rosea typically come from reputable manufacturers that emphasize stringent quality control and standardization processes. Here are some key factors to consider when selecting a Rhodiola Rosea supplement:

  1. Standardized Extracts: Look for supplements that provide a standardized extract of Rhodiola Rosea, typically containing 3% rosavins and 1% salidroside. These two compounds are considered the primary active ingredients responsible for the herb's adaptogenic effects. Standardization ensures that each dose contains a consistent amount of these bioactive compounds, maximizing efficacy and safety.
  2. Reputable Brands: Opt for well-known and reputable brands with a history of producing high-quality herbal supplements. Brands that adhere to Good Manufacturing Practices (GMP) and have their products tested by third-party laboratories for purity and potency are generally more reliable. This information is often available on the company's website or product packaging.
  3. Geographical Origin: Rhodiola Rosea thrives in high-altitude regions with harsh climates, such as the mountainous areas of Siberia, Tibet, and Scandinavia. Supplements sourced from these regions are often of higher quality due to the optimal growing conditions. When possible, choose products that specify the geographical origin of their Rhodiola Rosea.
  4. Organic and Non-GMO: Selecting organic and non-GMO Rhodiola Rosea supplements can further ensure the purity and quality of the product. Organic certification indicates that the herb was grown without the use of synthetic pesticides, herbicides, or fertilizers, and non-GMO status ensures that the plant has not been genetically modified.
  5. Capsule and Extract Forms: Rhodiola Rosea is available in various forms, including capsules, tablets, powders, and liquid extracts. Capsules and standardized liquid extracts are often preferred for their convenience and precise dosing. Make sure to choose a form that fits your lifestyle and preferences while ensuring the product meets the aforementioned quality criteria.
  6. Transparent Labeling: A high-quality Rhodiola Rosea supplement should have clear and transparent labeling, listing the concentration of active ingredients (rosavins and salidroside), the serving size, and any other ingredients or fillers. Avoid products with vague or incomplete labeling, as this may indicate lower quality or lack of thorough testing.

By considering these factors, you can identify the best sources of Rhodiola Rosea and ensure you are getting a high-quality supplement that delivers the full potential of this powerful adaptogenic herb. Always consult with a healthcare professional before starting any new supplement regimen to ensure it is appropriate for your individual health needs.

Back to table of contents


What forms does Rhodiola Rosea come in?

Rhodiola Rosea is available in several forms, each offering unique advantages depending on your preferences and health goals. Understanding these different forms can help you choose the one that best suits your needs.

  1. Capsules and Tablets: These are the most common and convenient forms of Rhodiola Rosea supplements. Capsules and tablets typically contain a standardized extract, ensuring consistent dosing of active compounds such as rosavins and salidroside. They are easy to take and store, making them a popular choice for daily supplementation. Many reputable brands offer Rhodiola Rosea in this form, often with clear labeling regarding dosage and active ingredient concentrations.
  2. Liquid Extracts and Tinctures: Liquid extracts and tinctures provide a highly concentrated form of Rhodiola Rosea, which can be taken alone or mixed with water or other beverages. These forms are quickly absorbed by the body, potentially offering faster effects. Liquid extracts are often preferred by individuals who have difficulty swallowing pills or who want to customize their dosage more precisely. It’s important to follow the manufacturer's dosage recommendations when using liquid extracts to ensure safe and effective use.
  3. Powder: Rhodiola Rosea powder is another versatile option. It can be mixed into smoothies, juices, or other foods, offering a flexible way to incorporate the herb into your diet. Powders may come in bulk containers or single-serving packets, making them convenient for use at home or on the go. When choosing a powder, look for products that provide clear information on the concentration of active compounds and ensure they are free from fillers or additives.
  4. Teas and Infusions: Some people prefer to consume Rhodiola Rosea as a tea or infusion. This form involves steeping dried Rhodiola Rosea root in hot water to extract its beneficial compounds. While this method is more traditional and can offer a soothing experience, it may provide less consistent dosing compared to standardized extracts. If you choose this form, make sure to use high-quality dried roots and follow recommended steeping times to maximize the extract's potency.
  5. Softgels: Softgel capsules are another option, often containing Rhodiola Rosea extract in an oil-based solution. Softgels can be easier to swallow than tablets or capsules and may offer improved bioavailability due to the oil-based medium. This form is also convenient and provides a standardized dose of Rhodiola Rosea.
  6. Chewables and Gummies: For those who prefer a more palatable form, Rhodiola Rosea is also available in chewable tablets or gummies. These forms are particularly appealing for individuals who do not like swallowing pills or for those who want a more enjoyable way to take their supplements. However, it's important to check for added sugars or artificial ingredients that may be present in these products.

In summary, Rhodiola Rosea is available in various forms, including capsules, tablets, liquid extracts, powders, teas, softgels, and chewables. Each form offers unique benefits, so the choice depends on your personal preferences, lifestyle, and specific health needs. Always ensure that the product you choose is from a reputable source and provides clear information on the concentration of active ingredients.

Back to table of contents


Which sub-compounds of Rhodiola Rosea, if any, are critical to the efficacy of Rhodiola Rosea?

The efficacy of Rhodiola Rosea is largely attributed to several key bioactive compounds, with rosavins and salidroside being the most critical. These compounds contribute significantly to the adaptogenic properties of Rhodiola Rosea, enhancing its ability to help the body resist stress and improve overall mental and physical performance.

  1. Rosavins: This group of compounds includes rosavin, rosin, and rosarin. Rosavins are often considered the primary active ingredients in Rhodiola Rosea, contributing to its adaptogenic effects. They are believed to play a significant role in modulating the body's stress response by influencing the release of stress hormones and enhancing the resilience of the nervous system. Studies have shown that rosavins can help reduce symptoms of fatigue, improve mood, and enhance cognitive function (Panossian et al., 2010).
  2. Salidroside: Salidroside is another crucial compound found in Rhodiola Rosea, known for its potent antioxidant and neuroprotective properties. It helps protect cells from oxidative stress and supports the health of the nervous system. Salidroside has been shown to improve physical endurance, reduce symptoms of anxiety and depression, and enhance cognitive performance. Research indicates that salidroside can increase levels of serotonin, dopamine, and norepinephrine in the brain, which are important neurotransmitters involved in mood regulation (Chen et al., 2009).
  3. P-tyrosol: P-tyrosol is a phenolic compound found in Rhodiola Rosea that contributes to its antioxidant properties. It helps neutralize free radicals and protect cells from oxidative damage. While p-tyrosol is not as prominently studied as rosavins and salidroside, it still plays a role in the overall efficacy of Rhodiola Rosea by supporting cellular health and reducing oxidative stress (De Sanctis et al., 2004).
  4. Other Phenolic Compounds: Rhodiola Rosea contains various other phenolic compounds, such as flavonoids and proanthocyanidins, which also contribute to its antioxidant and anti-inflammatory effects. These compounds work synergistically with rosavins and salidroside to enhance the herb's overall adaptogenic properties.

The standardized extracts of Rhodiola Rosea typically contain a specific ratio of rosavins and salidroside, often 3% rosavins and 1% salidroside. This standardization ensures a consistent and effective dosage of these critical compounds, maximizing the benefits of the supplement.

In summary, the efficacy of Rhodiola Rosea is primarily driven by its key bioactive compounds: rosavins, salidroside, and p-tyrosol. These compounds work together to modulate the stress response, protect against oxidative damage, and support overall mental and physical well-being. When choosing a Rhodiola Rosea supplement, it is important to look for products that are standardized to contain these critical compounds to ensure maximum efficacy.

Back to table of contents


What is Rhodiola Rosea also known as?

Rhodiola Rosea, a versatile adaptogenic herb, is known by various names and terms, reflecting its widespread use and cultural significance across different regions. Here’s a comprehensive list of the common names, abbreviations, chemical compounds, and ingredients associated with Rhodiola Rosea:

  1. Common Names:
    • Golden Root
    • Roseroot
    • Arctic Root
    • King’s Crown
    • Orpin Rose
  2. Scientific Name:
    • Rhodiola Rosea L. (with "L" denoting the Linnaean classification)
  3. Misspellings and Variations:
    • Rhodolia Rosea
    • Rhodila Rosea
    • Rhodiola Resea
    • Rhodiola Rosia
    • Rhodiola Rose
  4. Abbreviations:
    • R. Rosea
    • RR (often used in scientific literature)
  5. Chemical Compounds:
    • Rosavins:
      • Rosavin
      • Rosin
      • Rosarin
    • Salidroside (also known as Rhodioloside)
    • P-tyrosol (or Paratyrosol)
    • Other Phenolic Compounds:
      • Flavonoids
      • Proanthocyanidins
  6. Ingredients and Extracts:
    • Rhodiola Rosea Root Extract
    • SHR-5 (a standardized extract of Rhodiola Rosea)
    • WS® 1375 (another standardized extract, often used in clinical trials)
  7. Traditional and Regional Names:
    • In Russian: "Родиола розовая" (Rodiola rozovaya)
    • In Scandinavian languages: "Rosenrot" (used in Sweden and Norway)

These names and terms are used interchangeably in various contexts, including scientific research, traditional medicine, and commercial products. When selecting a Rhodiola Rosea supplement, it is important to recognize these different names and ensure the product contains standardized extracts with known concentrations of the key active compounds, such as rosavins and salidroside.

By understanding the various names and terminologies associated with Rhodiola Rosea, you can better navigate the available products and make informed choices to support your health and well-being.

Back to table of contents


What is important to look for on the label of a Rhodiola Rosea supplement to ensure product quality?

When selecting a Rhodiola Rosea supplement, it is crucial to carefully examine the product label to ensure you are choosing a high-quality and effective supplement. Here are the key factors to look for on the label:

  1. Standardization: Ensure that the supplement is standardized to contain a specific concentration of the active compounds, typically 3% rosavins and 1% salidroside. Standardization guarantees that each dose contains consistent and effective levels of these bioactive compounds, which are critical for the herb's adaptogenic properties.
  2. Dosage Information: Check the label for clear dosage instructions and the amount of Rhodiola Rosea extract per serving. Common dosages range from 200 to 600 mg per day. Ensure that the recommended dosage aligns with the concentrations used in clinical studies for the desired effects, such as stress reduction or enhanced physical performance.
  3. Purity and Ingredients: Look for a supplement that lists all ingredients, including any fillers, binders, or additives. A high-quality product should have minimal additional ingredients and should be free from artificial colors, flavors, and preservatives. If possible, choose a supplement that is labeled as non-GMO, organic, and free from common allergens such as gluten, soy, and dairy.
  4. Third-Party Testing: Verify if the product has been tested by an independent third-party laboratory for purity, potency, and quality. Third-party testing ensures that the supplement contains the stated amounts of active ingredients and is free from contaminants such as heavy metals, pesticides, and microbial impurities. Look for certifications or seals from reputable third-party testing organizations on the label.
  5. Manufacturer Information: Choose supplements from reputable manufacturers who adhere to Good Manufacturing Practices (GMP) and have a history of producing high-quality products. The label should include the manufacturer's name, address, and contact information, allowing you to research their reputation and quality control practices.
  6. Geographical Origin: If available, check the label for information on the geographical origin of the Rhodiola Rosea. High-quality Rhodiola Rosea is often sourced from high-altitude regions with harsh climates, such as Siberia, Tibet, and Scandinavia. Supplements that specify the origin of their raw materials may offer higher quality and potency.
  7. Extraction Method: The label should indicate the extraction method used to obtain the Rhodiola Rosea extract. Solvent-free extraction methods, such as water or ethanol extraction, are generally preferred as they preserve the integrity of the active compounds without introducing harmful residues.
  8. Expiration Date and Batch Number: Ensure the supplement has a clear expiration date and batch number. This information indicates the product's freshness and allows for traceability in case of any quality issues.

By paying attention to these factors on the label, you can select a high-quality Rhodiola Rosea supplement that is both safe and effective. Always consult with a healthcare professional before starting any new supplement regimen to ensure it is appropriate for your individual health needs.

Back to table of contents


Disclaimer & References

The information provided on this website, including any text, images, or other material contained within, is for informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. This page was created by the SuppCo editiorial team, with AI summarization tools, including data from but not limited to following studies:

  1. M. Cropley, A. Banks, J. Boyle (2015). The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytotherapy Research, 29, 1934 - 1939. Link: 10.1002/ptr.5486
  2. A. Palmeri, L. Mammana, Maria Rosaria Tropea, Walter Gulisano, D. Puzzo (2016). Salidroside, a Bioactive Compound of Rhodiola Rosea, Ameliorates Memory and Emotional Behavior in Adult Mice.. Journal of Alzheimer's disease : JAD, 52 1,
    65-75 . Link: 10.3233/JAD-151159
  3. Tina Koop, A. Dienel, M. Heldmann, T. Münte (2020). Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event‐related potential dual task study. Phytotherapy Research, 34, 3287 - 3297. Link: 10.1002/ptr.6778
  4. W. Dimpfel, L. Schombert, A. Panossian (2018). Assessing the Quality and Potential Efficacy of Commercial Extracts of Rhodiola rosea L. by Analyzing the Salidroside and Rosavin Content and the Electrophysiological Activity in Hippocampal Long-Term Potentiation, a Synaptic Model of Memory. Frontiers in Pharmacology, 9, . Link: 10.3389/fphar.2018.00425
  5. M. Heldmann, G. Roth, A. Dienel, T. Münte (2016). EP 116. Impact of Rhodiola Rosea extract WS1375 on electrophysiological correlates of attention allocation in a dual task paradigm. Clinical Neurophysiology, 127, . Link: 10.1016/j.clinph.2016.05.159
  6. Gouveia Ma, Qun Zheng, Meng-bei Xu, Xiao-li Zhou, Ling-yan Lu, Zuo-Xiao Li, Guo-qing Zheng (2018). Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms. Frontiers in Pharmacology, 9, . Link: 10.3389/fphar.2018.01415
  7. L. Vasileva, D. Getova, N. Doncheva, A. Marchev, Milen I Georgiev (2016). Beneficial effect of commercial Rhodiola extract in rats with scopolamine-induced memory impairment on active avoidance.. Journal of ethnopharmacology, 193,
    586-591 . Link: 10.1016/j.jep.2016.10.011
  8. Z. Qu, Yan Zhou, Yuan-shan Zeng, Yan Li, P. Chung (2009). Pretreatment with Rhodiola rosea extract reduces cognitive impairment induced by intracerebroventricular streptozotocin in rats: implication of anti-oxidative and neuroprotective effects.. Biomedical and environmental sciences : BES, 22 4,
    318-26 . Link: 10.1016/S0895-3988(09)60062-3
  9. S. Nabavi, N. Braidy, I. Orhan, A. Badiee, M. Daglia, S. Nabavi (2016). Rhodiola rosea L. and Alzheimer's Disease: From Farm to Pharmacy. Phytotherapy Research, 30, 532 - 539. Link: 10.1002/ptr.5569
  10. D. Muniz-Pumares, A. Lage-Guede, A. Firth-Clark, J. Allgrove (2011). Effects of acute supplementation with Rhodiola rosea and L-carnitine on exercise performance, cognitive function and cortisol in healthy active volunteers. British Journal of Sports Medicine, 45, A1 - A1. Link: 10.1136/bjsports-2011-090606.2
  11. A. Panossian, G. Wikman, J. Sarris, J. Sarris (2010). Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 17 7,
    481-93 . Link: 10.1016/j.phymed.2010.02.002
  12. A. Spasov, G. Wikman, V. B. Mandrikov, I. A. Mironova, V. V. Neumoin (2000). A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 7 2,
    85-9 . Link: 10.1016/S0944-7113(00)80078-1
  13. V. Darbinyan, A. Kteyan, A. Panossian, E. Gabrielian, G. Wikman, H. Wagner (2000). Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 7 5,
    365-71 . Link: 10.1016/S0944-7113(00)80055-0
  14. Dong-Zhou Kang, Hee‐Do Hong, Kyung-Im Kim, S. Choi (2015). Anti-Fatigue Effects of Fermented Rhodiola rosea Extract in Mice. Preventive Nutrition and Food Science, 20, 38 - 42. Link: 10.3746/pnf.2015.20.1.38
  15. S. Punja, Larissa Shamseer, K. Olson, S. Vohra (2014). Rhodiola Rosea for Mental and Physical Fatigue in Nursing Students: A Randomized Controlled Trial. PLoS ONE, 9, . Link: 10.1371/journal.pone.0108416
  16. Josefin Blomkvist, A. Taube, D. Larhammar (2009). Perspective on Roseroot (Rhodiola rosea) studies.. Planta medica, 75 11,
    1187-90 . Link: 10.1055/s-0029-1185720
  17. Y. Lekomtseva, I. Zhukova, Anna Wacker (2017). Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial. Complementary Medicine Research, 24, 46 - 52. Link: 10.1159/000457918
  18. Emilija Ivanova Stojcheva, J. Quintela (2022). The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging Clinical Evidence. Molecules, 27, . Link: 10.3390/molecules27123902
  19. Efsa Panel on Dietetic Products (2012). Scientific opinion on the substantiation of a health claim related to Rhodiola rosea L. extract and reduction of mental fatigue pursuant to Article 13(5) of Regulation (EC) No 1924/2006.. EFSA Journal, 10, . Link: 10.2903/J.EFSA.2012.2805
  20. Wan-Li Chu, Mon-Chien Lee, Y. Hsu, Chi-Chang Huang, Yu-Jou Chien (2023). Effect of Rhodiola Rosea Supplement on Exhaustive Swimming Test and Physical Fatigue in Male Institute of Cancer Research Mice. Sports and Exercise Medicine – Open Journal, , . Link: 10.17140/semoj-9-189
  21. S. Zheng, D.W. Liu (2023). Comparing Efficacy of Rhodiola Rosea, Red Goji Berry, and Siraitia Grosvenorii in Physical Recovery After Aerobic Exercise. CURRENT TOPICS IN NUTRACEUTICAL RESEARCH, , . Link: 10.37290/ctnr2641-452x.21:326-331
  22. Chang Liu, Haotian Zhao, Yi Yan, Weijun Yang, Songyue Chen, Geun-Ho Song, Xuehan Li, Yujia Gu, Hezhang Yun, Yi Li (2023). Synergistic Effect of Rhodiola rosea and Caffeine Supplementation on the Improvement of Muscle Strength and Muscular Endurance: A Pilot Study for Rats, Resistance Exercise-Untrained and -Trained Volunteers. Nutrients, 15, . Link: 10.3390/nu15030582
  23. A. Parisi, E. Tranchita, G. Duranti, E. Ciminelli, F. Quaranta, R. Ceci, C. Cerulli, P. Borrione, S. Sabatini (2010). Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results.. The Journal of sports medicine and physical fitness, 50 1,
    57-63 . Link:
  24. Patricia M Sanz-Barrio, E. E. Noreen, Laura Gilsanz-Estebaranz, Jorge Lorenzo-Calvo, María Martínez-Ferrán, H. Pareja-Galeano (2023). Rhodiola rosea supplementation on sports performance: A systematic review of randomized controlled trials. Phytotherapy Research, 37, 4414 - 4428. Link: 10.1002/ptr.7950
  25. Thomas B. Walker, S. Altobelli, A. Caprihan, R. Robergs (2007). Failure of Rhodiola rosea to alter skeletal muscle phosphate kinetics in trained men.. Metabolism: clinical and experimental, 56 8,
    1111-7 . Link: 10.1016/J.METABOL.2007.04.004
  26. Yao Lu, Bin Deng, Luhua Xu, Hanjiao Liu, Yinzhi Song, Fengxia Lin (2022). Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review. Frontiers in Nutrition, 9, . Link: 10.3389/fnut.2022.856287
  27. M. Duncan, N. Clarke (2014). The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate, Substrate Utilisation, Mood State, and Perceptions of Exertion, Arousal, and Pleasure/Displeasure in Active Men. Journal of Sports Medicine, 2014, . Link: 10.1155/2014/563043
  28. Vince C Kreipke PhD, Robert J Moffatt PhD, Charles J Tanner Ma, Michael J Ormsbee PhD (2020). Effects of Concurrent Training and a Multi-Ingredient Performance Supplement Containing Rhodiola rosea and Cordyceps sinensis on Body Composition, Performance, and Health in Active Men. Journal of Dietary Supplements, 18, 597 - 613. Link: 10.1080/19390211.2020.1822486
  29. C. Ballmann, Shelby B. Maze, Abby C. Wells, Mallory M Marshall, R. Rogers (2018). Effects of short-term Rhodiola Rosea (Golden Root Extract) supplementation on anaerobic exercise performance. Journal of Sports Sciences, 37, 1003 - 998. Link: 10.1080/02640414.2018.1538028
  30. M. Cropley, A. Banks, J. Boyle (2015). The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytotherapy Research, 29, 1934 - 1939. Link: 10.1002/ptr.5486
  31. J. Amsterdam, A. Panossian (2016). Rhodiola rosea L. as a putative botanical antidepressant.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 23 7,
    770-83 . Link: 10.1016/j.phymed.2016.02.009
  32. A. Panossian, G. Wikman, J. Sarris, J. Sarris (2010). Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 17 7,
    481-93 . Link: 10.1016/j.phymed.2010.02.002
  33. Ipek Süntar (2019). Rhodiola (Rhodiola rosea L.). {"title"=>"", "scimago_quartile"=>nil}, , 383-400. Link: 10.1016/B978-0-12-812491-8.00052-7
  34. A. Palmeri, L. Mammana, Maria Rosaria Tropea, Walter Gulisano, D. Puzzo (2016). Salidroside, a Bioactive Compound of Rhodiola Rosea, Ameliorates Memory and Emotional Behavior in Adult Mice.. Journal of Alzheimer's disease : JAD, 52 1,
    65-75 . Link: 10.3233/JAD-151159
  35. Yun-Fang Hao, Ting Luo, Zhongyu Lu, Chun-Yan Shen, Jian-Guo Jiang (2021). Targets and underlying mechanisms related to the sedative and hypnotic activities of saponins from Rhodiola rosea L. (crassulaceae).. Food & function, , . Link: 10.1039/d1fo01178b
  36. C. Cayer, F. Ahmed, Vicky Filion, A. Saleem, A. Cuerrier, M. Allard, G. Rochefort, Z. Merali, J. Arnason (2013). Characterization of the Anxiolytic Activity of Nunavik Rhodiola rosea. Planta Medica, 79, 1385 - 1391. Link: 10.1055/s-0033-1350709
  37. H. Yu, P. Zhang, C. Zhang, X. Zhang, Z. Li, W. Li, A. Fu (2019). [Effects of rhodiola rosea on oxidative stress and negative emotional states in patients with obstructive sleep apnea].. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 33 10,
    954-957 . Link: 10.13201/j.issn.1001-1781.2019.10.013
  38. Fanaras Konstantinos, R. Heun (2020). The effects of Rhodiola Rosea supplementation on depression, anxiety and mood – A Systematic Review. Global Psychiatry, 3, 72 - 82. Link: 10.2478/gp-2019-0022
  39. A. Bystritsky, Lauren E Kerwin, Jamie D. Feusner (2008). A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD).. Journal of alternative and complementary medicine, 14 2,
    175-80 . Link: 10.1089/acm.2007.7117
  40. M. Duncan, N. Clarke (2014). The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate, Substrate Utilisation, Mood State, and Perceptions of Exertion, Arousal, and Pleasure/Displeasure in Active Men. Journal of Sports Medicine, 2014, . Link: 10.1155/2014/563043
  41. Tina Koop, A. Dienel, M. Heldmann, T. Münte (2020). Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event‐related potential dual task study. Phytotherapy Research, 34, 3287 - 3297. Link: 10.1002/ptr.6778
  42. M. Heldmann, G. Roth, A. Dienel, T. Münte (2016). EP 116. Impact of Rhodiola Rosea extract WS1375 on electrophysiological correlates of attention allocation in a dual task paradigm. Clinical Neurophysiology, 127, . Link: 10.1016/j.clinph.2016.05.159
  43. W. Dimpfel, L. Schombert, A. Panossian (2018). Assessing the Quality and Potential Efficacy of Commercial Extracts of Rhodiola rosea L. by Analyzing the Salidroside and Rosavin Content and the Electrophysiological Activity in Hippocampal Long-Term Potentiation, a Synaptic Model of Memory. Frontiers in Pharmacology, 9, . Link: 10.3389/fphar.2018.00425
  44. Katrien De Bock, B. O. Eijnde, M. Ramaekers, P. Hespel (2004). Acute Rhodiola rosea intake can improve endurance exercise performance.. International journal of sport nutrition and exercise metabolism, 14 3,
    298-307 . Link: 10.1123/IJSNEM.14.3.298
  45. D. Muniz-Pumares, A. Lage-Guede, A. Firth-Clark, J. Allgrove (2011). Effects of acute supplementation with Rhodiola rosea and L-carnitine on exercise performance, cognitive function and cortisol in healthy active volunteers. British Journal of Sports Medicine, 45, A1 - A1. Link: 10.1136/bjsports-2011-090606.2
  46. A. Palmeri, L. Mammana, Maria Rosaria Tropea, Walter Gulisano, D. Puzzo (2016). Salidroside, a Bioactive Compound of Rhodiola Rosea, Ameliorates Memory and Emotional Behavior in Adult Mice.. Journal of Alzheimer's disease : JAD, 52 1,
    65-75 . Link: 10.3233/JAD-151159
  47. Gouveia Ma, Qun Zheng, Meng-bei Xu, Xiao-li Zhou, Ling-yan Lu, Zuo-Xiao Li, Guo-qing Zheng (2018). Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms. Frontiers in Pharmacology, 9, . Link: 10.3389/fphar.2018.01415
  48. E. Jówko, J. Sadowski, B. Długołȩcka, D. Gierczuk, B. Opaszowski, I. Cieśliński (2016). Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men. Journal of Sport and Health Science, 7, 473 - 480. Link: 10.1016/j.jshs.2016.05.005
  49. C. Concerto, Carmenrita Infortuna, M. Muscatello, A. Bruno, R. Zoccali, E. Chusid, E. Aguglia, F. Battaglia (2018). Exploring the effect of adaptogenic Rhodiola Rosea extract on neuroplasticity in humans.. Complementary therapies in medicine, 41,
    141-146 . Link: 10.1016/j.ctim.2018.09.013
  50. Dong-Zhou Kang, Hee‐Do Hong, Kyung-Im Kim, S. Choi (2015). Anti-Fatigue Effects of Fermented Rhodiola rosea Extract in Mice. Preventive Nutrition and Food Science, 20, 38 - 42. Link: 10.3746/pnf.2015.20.1.38
  51. Tyler D. Williams, Haley N Langley, Caleb C Roberson, R. Rogers, C. Ballmann (2021). Effects of Short-Term Golden Root Extract (Rhodiola rosea) Supplementation on Resistance Exercise Performance. International Journal of Environmental Research and Public Health, 18, . Link: 10.3390/ijerph18136953
  52. A. Parisi, E. Tranchita, G. Duranti, E. Ciminelli, F. Quaranta, R. Ceci, C. Cerulli, P. Borrione, S. Sabatini (2010). Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results.. The Journal of sports medicine and physical fitness, 50 1,
    57-63 . Link:
  53. E. E. Noreen, J. Buckley, S. Lewis, J. Brandauer, K. Stuempfle (2013). The Effects of an Acute Dose of Rhodiola rosea on Endurance Exercise Performance. Journal of Strength and Conditioning Research, 27, 839–847. Link: 10.1519/JSC.0b013e31825d9799
  54. Patricia M Sanz-Barrio, E. E. Noreen, Laura Gilsanz-Estebaranz, Jorge Lorenzo-Calvo, María Martínez-Ferrán, H. Pareja-Galeano (2023). Rhodiola rosea supplementation on sports performance: A systematic review of randomized controlled trials. Phytotherapy Research, 37, 4414 - 4428. Link: 10.1002/ptr.7950
  55. S. Zheng, D.W. Liu (2023). Comparing Efficacy of Rhodiola Rosea, Red Goji Berry, and Siraitia Grosvenorii in Physical Recovery After Aerobic Exercise. CURRENT TOPICS IN NUTRACEUTICAL RESEARCH, , . Link: 10.37290/ctnr2641-452x.21:326-331
  56. D. Muniz-Pumares, A. Lage-Guede, A. Firth-Clark, J. Allgrove (2011). Effects of acute supplementation with Rhodiola rosea and L-carnitine on exercise performance, cognitive function and cortisol in healthy active volunteers. British Journal of Sports Medicine, 45, A1 - A1. Link: 10.1136/bjsports-2011-090606.2
  57. Ana Skarpanska-Stejnborn, L. Pilaczyńska-Szcześniak, P. Basta, E. Deskur-Śmielecka (2009). The influence of supplementation with Rhodiola rosea L. extract on selected redox parameters in professional rowers.. International journal of sport nutrition and exercise metabolism, 19 2,
    186-99 . Link: 10.1123/IJSNEM.19.2.186
  58. M. Duncan, J. Tallis, S. Wilson, N. Clarke (2016). The Effect of Caffeine and Rhodiola Rosea, Alone or in Combination, on 5-km Running Performance in Men. Journal of caffeine research, 6, 40-48. Link: 10.1089/JCR.2015.0025
  59. Yao Lu, Bin Deng, Luhua Xu, Hanjiao Liu, Yinzhi Song, Fengxia Lin (2022). Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review. Frontiers in Nutrition, 9, . Link: 10.3389/fnut.2022.856287
  60. A. Dinel, I. Guinobert, C. Lucas, C. Blondeau, V. Bardot, I. Ripoche, L. Berthomier, V. Pallet, S. Layé, C. Joffre (2019). Reduction of acute mild stress corticosterone response and changes in stress‐responsive gene expression in male Balb/c mice after repeated administration of a Rhodiola rosea L. root extract. Food Science & Nutrition, 7, 3827 - 3841. Link: 10.1002/fsn3.1249
  61. A. Panossian, G. Wikman, J. Sarris, J. Sarris (2010). Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 17 7,
    481-93 . Link: 10.1016/j.phymed.2010.02.002
  62. P. Gerbarg, Richard P. Brown (2016). Pause menopause with Rhodiola rosea, a natural selective estrogen receptor modulator.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 23 7,
    763-9 . Link: 10.1016/j.phymed.2015.11.013
  63. C. Concerto, Carmenrita Infortuna, M. Muscatello, A. Bruno, R. Zoccali, E. Chusid, E. Aguglia, F. Battaglia (2018). Exploring the effect of adaptogenic Rhodiola Rosea extract on neuroplasticity in humans.. Complementary therapies in medicine, 41,
    141-146 . Link: 10.1016/j.ctim.2018.09.013
  64. J. Amsterdam, A. Panossian (2016). Rhodiola rosea L. as a putative botanical antidepressant.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 23 7,
    770-83 . Link: 10.1016/j.phymed.2016.02.009
  65. E. Jówko, J. Sadowski, B. Długołȩcka, D. Gierczuk, B. Opaszowski, I. Cieśliński (2016). Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men. Journal of Sport and Health Science, 7, 473 - 480. Link: 10.1016/j.jshs.2016.05.005
  66. A. Agapouda, A. Grimm, I. Lejri, A. Eckert (2022). Rhodiola Rosea Extract Counteracts Stress in an Adaptogenic Response Curve Manner via Elimination of ROS and Induction of Neurite Outgrowth. Oxidative Medicine and Cellular Longevity, 2022, . Link: 10.1155/2022/5647599
  67. D. Muniz-Pumares, A. Lage-Guede, A. Firth-Clark, J. Allgrove (2011). Effects of acute supplementation with Rhodiola rosea and L-carnitine on exercise performance, cognitive function and cortisol in healthy active volunteers. British Journal of Sports Medicine, 45, A1 - A1. Link: 10.1136/bjsports-2011-090606.2
  68. Emilija Ivanova Stojcheva, J. Quintela (2022). The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging Clinical Evidence. Molecules, 27, . Link: 10.3390/molecules27123902
  69. M. Duncan, N. Clarke (2014). The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate, Substrate Utilisation, Mood State, and Perceptions of Exertion, Arousal, and Pleasure/Displeasure in Active Men. Journal of Sports Medicine, 2014, . Link: 10.1155/2014/563043
  70. Nan Xia, J. Li, Hongwei Wang, Jian Wang, Yang-tian Wang (2016). Schisandra chinensis and Rhodiola rosea exert an anti-stress effect on the HPA axis and reduce hypothalamic c-Fos expression in rats subjected to repeated stress.. Experimental and therapeutic medicine, 11 1,
    353-359 . Link: 10.3892/ETM.2015.2882
  71. Afanas'ev Sa, Krylatov Av, Lasukova Tv, Y. Lishmanov (1996). PARTICIPATION OF INDUCIBLE STRESS PROTEINS IN THE CARDIOPROTECTIVE EFFECT OF RHODIOLAE ROSEA. Biochemistry, 61, 1258-1261. Link:
  72. M. Battistelli, R. Sanctis, R. Bellis, L. Cucchiarini, Marina Dachà, Pietro Gobbi (2005). Rhodiola rosea as antioxidant in red blood cells: ultrastructural and hemolytic behaviour.. European journal of histochemistry : EJH, 49 3,
    243-54 . Link: 10.4081/951
  73. R. de Sanctis, R. De Bellis, C. Scesa, U. Mancini, L. Cucchiarini, M. Dachá (2004). In vitro protective effect of Rhodiola rosea extract against hypochlorous acid‐induced oxidative damage in human erythrocytes. BioFactors, 20, . Link: 10.1002/BIOF.5520200304
  74. Yuanxia Cheng (2019). The growth performance and nonspecific immunity of red swamp crayfish Procambarus clarkia affected by dietary Rhodiola rosea polysaccharide.. Fish & shellfish immunology, , . Link: 10.1016/j.fsi.2019.08.046
  75. A. Hernandez-Santana, V. Perez-Lopez, J. Zubeldia, M. Jiménez‐del‐Rio (2014). A Rhodiola Rosea Root Extract Protects Skeletal Muscle Cells Against Chemically Induced Oxidative Stress by Modulating Heat Shock Protein 70 (HSP70) Expression. Phytotherapy Research, 28, . Link: 10.1002/ptr.5046
  76. V. Borgonetti, P. Governa, M. Biagi, P. Dalia, L. Corsi (2019). Rhodiola rosea L. modulates inflammatory processes in a CRH-activated BV2 cell model.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 68,
    153143 . Link: 10.1016/j.phymed.2019.153143
  77. Hsiu-Mei Chiang, Yin-Chih Chien, Chieh-Hsi Wu, Y. Kuo, Wan-Chen Wu, Yucai Pan, Yu-Han Su, K. Wen (2014). Hydroalcoholic extract of Rhodiola rosea L. (Crassulaceae) and its hydrolysate inhibit melanogenesis in B16F0 cells by regulating the CREB/MITF/tyrosinase pathway.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 65,
    129-39 . Link: 10.1016/j.fct.2013.12.032
  78. R. Shanely, D. Nieman, K. Zwetsloot, A. Knab, H. Imagita, Beibei Luo, Barbara Davis, J. Zubeldia (2014). Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon. Brain, Behavior, and Immunity, 39, 204-210. Link: 10.1016/j.bbi.2013.09.005
  79. M. Abidov, S. Grachev, R. Seifulla, T. Ziegenfuss (2004). Extract of Rhodiola rosea Radix Reduces the Level of C-Reactive Protein and Creatinine Kinase in the Blood. Bulletin of Experimental Biology and Medicine, 138, 63-64. Link: 10.1023/B:BEBM.0000046940.45382.53
  80. M. Cropley, A. Banks, J. Boyle (2015). The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytotherapy Research, 29, 1934 - 1939. Link: 10.1002/ptr.5486
  81. J. Amsterdam, A. Panossian (2016). Rhodiola rosea L. as a putative botanical antidepressant.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 23 7,
    770-83 . Link: 10.1016/j.phymed.2016.02.009
  82. Fanaras Konstantinos, R. Heun (2020). The effects of Rhodiola Rosea supplementation on depression, anxiety and mood – A Systematic Review. Global Psychiatry, 3, 72 - 82. Link: 10.2478/gp-2019-0022
  83. J. Mao, S. Xie, J. Zee, Irene Soeller, Qing S Li, K. Rockwell, J. Amsterdam (2015). Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 22 3,
    394-9 . Link: 10.1016/j.phymed.2015.01.010
  84. V. Darbinyan, G. Aslanyan, E. Amroyan, E. Gabrielyan, C. Malmström, A. Panossian (2007). Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nordic Journal of Psychiatry, 61, 343 - 348. Link: 10.1080/08039480701643290
  85. S. Ross (2014). Rhodiola rosea (SHR-5), Part 2: A Standardized Extract of Rhodiola rosea Is Shown to Be Effective in the Treatment of Mild to Moderate Depression. Holistic Nursing Practice, 28, 217–221. Link: 10.1097/HNP.0000000000000030
  86. J. Mao, Qing S Li, Irene Soeller, S. Xie, J. Amsterdam (2014). Rhodiola rosea therapy for major depressive disorder: a study protocol for a randomized, double-blind, placebo- controlled trial.. Journal of clinical trials, 4,
    170 . Link: 10.4172/2167-0870.1000170
  87. Q. Chen, Y. Zeng, Z. Qu, J. Tang, Y. Qin, P. Chung, R. Wong, Urban Hägg (2009). The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 16 9,
    830-8 . Link: 10.1016/j.phymed.2009.03.011
  88. H. Yu, P. Zhang, C. Zhang, X. Zhang, Z. Li, W. Li, A. Fu (2019). [Effects of rhodiola rosea on oxidative stress and negative emotional states in patients with obstructive sleep apnea].. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 33 10,
    954-957 . Link: 10.13201/j.issn.1001-1781.2019.10.013
  89. M. Perfumi, L. Mattioli (2007). Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytotherapy Research, 21, . Link: 10.1002/PTR.2013
  90. G. Tinsley, A. Jagim, Gregory D. M. Potter, Dan Garner, A. Galpin (2023). Rhodiola Rosea as an Adaptogen to Enhance Exercise Performance: A Review of the Literature.. The British journal of nutrition, ,
    1-27 . Link: 10.1017/S0007114523001988
  91. Yao Lu, Bin Deng, Luhua Xu, Hanjiao Liu, Yinzhi Song, Fengxia Lin (2022). Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review. Frontiers in Nutrition, 9, . Link: 10.3389/fnut.2022.856287
  92. R. Shanely, D. Nieman, K. Zwetsloot, A. Knab, H. Imagita, Beibei Luo, Barbara Davis, J. Zubeldia (2014). Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon. Brain, Behavior, and Immunity, 39, 204-210. Link: 10.1016/j.bbi.2013.09.005
  93. Patricia M Sanz-Barrio, E. E. Noreen, Laura Gilsanz-Estebaranz, Jorge Lorenzo-Calvo, María Martínez-Ferrán, H. Pareja-Galeano (2023). Rhodiola rosea supplementation on sports performance: A systematic review of randomized controlled trials. Phytotherapy Research, 37, 4414 - 4428. Link: 10.1002/ptr.7950
  94. A. Parisi, E. Tranchita, G. Duranti, E. Ciminelli, F. Quaranta, R. Ceci, C. Cerulli, P. Borrione, S. Sabatini (2010). Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results.. The Journal of sports medicine and physical fitness, 50 1,
    57-63 . Link:
  95. E. Jówko, J. Sadowski, B. Długołȩcka, D. Gierczuk, B. Opaszowski, I. Cieśliński (2016). Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men. Journal of Sport and Health Science, 7, 473 - 480. Link: 10.1016/j.jshs.2016.05.005
  96. A. Hernandez-Santana, V. Perez-Lopez, J. Zubeldia, M. Jiménez‐del‐Rio (2014). A Rhodiola Rosea Root Extract Protects Skeletal Muscle Cells Against Chemically Induced Oxidative Stress by Modulating Heat Shock Protein 70 (HSP70) Expression. Phytotherapy Research, 28, . Link: 10.1002/ptr.5046
  97. C-H. Lin, C. Hsu, S. Lin, Meng-Yu Hsu (2019). Rhodiola rosea does not reduce in vivo inflammatory activity after continuous endurance exercise. Science & Sports, , . Link: 10.1016/J.SCISPO.2018.10.006
  98. Bo-ra Yoon, Young Jun Lee, Hee‐Do Hong, Su-Kyung Sung, O. Lee (2012). Fermented mixture of Rhodiola rosea and Korean red ginseng protects differentiated C2C12 cells from hydrogen peroxideinduced oxidative stress associated with antioxidant enzyme responses. The FASEB Journal, 26, . Link: 10.1096/fasebj.26.1_supplement.lb292
  99. P. Sist, F. Tramer, P. Lorenzon, R. Urbani, U. Vrhovsek, A. Bernareggi, M. Sciancalepore (2018). Rhodiola rosea, a protective antioxidant for intense physical exercise: An in vitro study. Journal of Functional Foods, , . Link: 10.1016/J.JFF.2018.06.022
  100. Patricia M Sanz-Barrio, E. E. Noreen, Laura Gilsanz-Estebaranz, Jorge Lorenzo-Calvo, María Martínez-Ferrán, H. Pareja-Galeano (2023). Rhodiola rosea supplementation on sports performance: A systematic review of randomized controlled trials. Phytotherapy Research, 37, 4414 - 4428. Link: 10.1002/ptr.7950
  101. Yao Lu, Bin Deng, Luhua Xu, Hanjiao Liu, Yinzhi Song, Fengxia Lin (2022). Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review. Frontiers in Nutrition, 9, . Link: 10.3389/fnut.2022.856287
  102. Katrien De Bock, B. O. Eijnde, M. Ramaekers, P. Hespel (2004). Acute Rhodiola rosea intake can improve endurance exercise performance.. International journal of sport nutrition and exercise metabolism, 14 3,
    298-307 . Link: 10.1123/IJSNEM.14.3.298
  103. M. Duncan, J. Tallis, S. Wilson, N. Clarke (2016). The Effect of Caffeine and Rhodiola Rosea, Alone or in Combination, on 5-km Running Performance in Men. Journal of caffeine research, 6, 40-48. Link: 10.1089/JCR.2015.0025
  104. S. Timpmann, A. Hackney, M. Tamm, K. Kreegipuu, E. Unt, V. Ööpik (2018). Influence of Rhodiola rosea on the heat acclimation process in young healthy men.. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 43 1,
    63-70 . Link: 10.1139/apnm-2017-0372
  105. E. Jówko, J. Sadowski, B. Długołȩcka, D. Gierczuk, B. Opaszowski, I. Cieśliński (2016). Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men. Journal of Sport and Health Science, 7, 473 - 480. Link: 10.1016/j.jshs.2016.05.005
  106. M. Duncan, N. Clarke (2014). The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate, Substrate Utilisation, Mood State, and Perceptions of Exertion, Arousal, and Pleasure/Displeasure in Active Men. Journal of Sports Medicine, 2014, . Link: 10.1155/2014/563043
  107. Thomas B. Walker, S. Altobelli, A. Caprihan, R. Robergs (2007). Failure of Rhodiola rosea to alter skeletal muscle phosphate kinetics in trained men.. Metabolism: clinical and experimental, 56 8,
    1111-7 . Link: 10.1016/J.METABOL.2007.04.004
  108. E. E. Noreen, J. Buckley, S. Lewis, J. Brandauer, K. Stuempfle (2013). The Effects of an Acute Dose of Rhodiola rosea on Endurance Exercise Performance. Journal of Strength and Conditioning Research, 27, 839–847. Link: 10.1519/JSC.0b013e31825d9799
  109. Priscila Lamadrid, Danielle K. Williams, M. Kilpatrick, P. Bickford, C. Sanberg (2019). The Impact of Dietary Supplement NT-020 with Rhodiola Rosea on Energy, Fatigue, and Perceived Exertion. Functional Foods in Health and Disease, 9, 706-718. Link: 10.31989/ffhd.v9i11.656
  110. A. Spasov, G. Wikman, V. B. Mandrikov, I. A. Mironova, V. V. Neumoin (2000). A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 7 2,
    85-9 . Link: 10.1016/S0944-7113(00)80078-1
  111. Emilija Ivanova Stojcheva, J. Quintela (2022). The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging Clinical Evidence. Molecules, 27, . Link: 10.3390/molecules27123902
  112. D. Edwards, A. Heufelder, A. Zimmermann (2012). Therapeutic Effects and Safety of Rhodiola rosea Extract WS® 1375 in Subjects with Life‐stress Symptoms – Results of an Open‐label Study. Phytotherapy Research, 26, . Link: 10.1002/ptr.3712
  113. I. Anghelescu, D. Edwards, E. Seifritz, S. Kasper (2018). Stress management and the role of Rhodiola rosea: a review. International Journal of Psychiatry in Clinical Practice, 22, 242 - 252. Link: 10.1080/13651501.2017.1417442
  114. S. Ross (2014). Rhodiola rosea (SHR-5), Part I: A Proprietary Root Extract of Rhodiola rosea is found to be Effective in the Treatment of Stress-Related Fatigue. Holistic Nursing Practice, 28, 149–154. Link: 10.1097/HNP.0000000000000014
  115. J. Amsterdam, A. Panossian (2016). Rhodiola rosea L. as a putative botanical antidepressant.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 23 7,
    770-83 . Link: 10.1016/j.phymed.2016.02.009
  116. L. Mattioli, C. Funari, M. Perfumi (2009). Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats. Journal of Psychopharmacology, 23, 130 - 142. Link: 10.1177/0269881108089872
  117. A. Agapouda, A. Grimm, I. Lejri, A. Eckert (2022). Rhodiola Rosea Extract Counteracts Stress in an Adaptogenic Response Curve Manner via Elimination of ROS and Induction of Neurite Outgrowth. Oxidative Medicine and Cellular Longevity, 2022, . Link: 10.1155/2022/5647599
  118. C. Concerto, Carmenrita Infortuna, M. Muscatello, A. Bruno, R. Zoccali, E. Chusid, E. Aguglia, F. Battaglia (2018). Exploring the effect of adaptogenic Rhodiola Rosea extract on neuroplasticity in humans.. Complementary therapies in medicine, 41,
    141-146 . Link: 10.1016/j.ctim.2018.09.013
  119. M. Cropley, A. Banks, J. Boyle (2015). The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytotherapy Research, 29, 1934 - 1939. Link: 10.1002/ptr.5486
  120. A. Spasov, G. Wikman, V. B. Mandrikov, I. A. Mironova, V. V. Neumoin (2000). A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 7 2,
    85-9 . Link: 10.1016/S0944-7113(00)80078-1
  121. L. Mattioli, C. Funari, M. Perfumi (2009). Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats. Journal of Psychopharmacology, 23, 130 - 142. Link: 10.1177/0269881108089872
  122. M. Cropley, A. Banks, J. Boyle (2015). The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytotherapy Research, 29, 1934 - 1939. Link: 10.1002/ptr.5486
  123. S. Hung, R. Perry, E. Ernst (2011). The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 18 4,
    235-44 . Link: 10.1016/j.phymed.2010.08.014
  124. Yao Lu, Bin Deng, Luhua Xu, Hanjiao Liu, Yinzhi Song, Fengxia Lin (2022). Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review. Frontiers in Nutrition, 9, . Link: 10.3389/fnut.2022.856287
  125. D. Edwards, A. Heufelder, A. Zimmermann (2012). Therapeutic Effects and Safety of Rhodiola rosea Extract WS® 1375 in Subjects with Life‐stress Symptoms – Results of an Open‐label Study. Phytotherapy Research, 26, . Link: 10.1002/ptr.3712
  126. M. Duncan, N. Clarke (2014). The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate, Substrate Utilisation, Mood State, and Perceptions of Exertion, Arousal, and Pleasure/Displeasure in Active Men. Journal of Sports Medicine, 2014, . Link: 10.1155/2014/563043
  127. J. Amsterdam, A. Panossian (2016). Rhodiola rosea L. as a putative botanical antidepressant.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 23 7,
    770-83 . Link: 10.1016/j.phymed.2016.02.009
  128. C. Concerto, Carmenrita Infortuna, M. Muscatello, A. Bruno, R. Zoccali, E. Chusid, E. Aguglia, F. Battaglia (2018). Exploring the effect of adaptogenic Rhodiola Rosea extract on neuroplasticity in humans.. Complementary therapies in medicine, 41,
    141-146 . Link: 10.1016/j.ctim.2018.09.013
  129. E. Jówko, J. Sadowski, B. Długołȩcka, D. Gierczuk, B. Opaszowski, I. Cieśliński (2016). Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men. Journal of Sport and Health Science, 7, 473 - 480. Link: 10.1016/j.jshs.2016.05.005

Back to table of contents

These statements have not been evaluated by the Food and Drug Administration. Any products and informational content displayed on this page are not intended to diagnose, treat, cure, or prevent any disease.