Olive Leaf Extract is a natural supplement derived from the leaves of the olive tree (Olea europaea). Unlike olive oil, which is extracted from the fruit of the olive tree, olive leaf extract is specifically obtained from the leaves, which contain a unique blend of potent bioactive compounds.
About Olive Leaf Extract
- What is Olive Leaf Extract?
- What is Olive Leaf Extract used for, and what do the studies say?
- How does Olive Leaf Extract work?
- How is Olive Leaf Extract used differently in men’s and women’s health?
- How much Olive Leaf Extract should I take?
- What are the main side effects of Olive Leaf Extract?
- Who should not take Olive Leaf Extract?
- Are Olive Leaf Extract supplements known to interact with any medications?
- What are the best sources of Olive Leaf Extract?
- What forms does Olive Leaf Extract come in?
- Which sub-compounds of Olive Leaf Extract, if any, are critical to the efficacy of Olive Leaf Extract?
- What is Olive Leaf Extract also known as?
- What is important to look for on the label of a Olive Leaf Extract supplement to ensure product quality?
- Disclaimer & References
What is Olive Leaf Extract?
Olive Leaf Extract is a natural supplement derived from the leaves of the olive tree (Olea europaea). Unlike olive oil, which is extracted from the fruit of the olive tree, olive leaf extract is specifically obtained from the leaves, which contain a unique blend of potent bioactive compounds. Among these compounds, oleuropein stands out as the most significant due to its numerous health benefits.
The history of using olive leaves for medicinal purposes dates back centuries, with traditional Mediterranean and Middle Eastern cultures harnessing their healing properties. Modern science has confirmed many of these traditional uses, highlighting the extract's antioxidant, anti-inflammatory, and antimicrobial qualities. These properties are attributed to the high concentration of phenolic compounds in the leaves, including oleuropein, hydroxytyrosol, and other flavonoids.
Olive Leaf Extract is available in various forms, including capsules, tablets, tinctures, and teas, making it accessible for different preferences and needs. Its rising popularity in the health and wellness community is due to its potential benefits for cardiovascular health, blood sugar regulation, and immune system support. As research continues to unfold, olive leaf extract remains a promising natural remedy with a solid foundation in both historical use and scientific validation.
What is Olive Leaf Extract used for, and what do the studies say?
Olive Leaf Extract is utilized for a variety of health-promoting purposes, primarily due to its rich composition of phenolic compounds like oleuropein and hydroxytyrosol. One of the most notable uses of olive leaf extract is its potential to support cardiovascular health. Studies have shown that olive leaf extract can help lower blood pressure in individuals with hypertension. For instance, a study published in the "European Journal of Nutrition" found that olive leaf extract significantly reduced both systolic and diastolic blood pressure in pre-hypertensive males, suggesting its hypotensive and lipid-lowering effects (Lockyer et al., 2016).
In addition to its cardiovascular benefits, olive leaf extract is also explored for its role in managing blood sugar levels. Research indicates that it may improve insulin sensitivity and help regulate blood glucose levels. A randomized, placebo-controlled trial involving middle-aged overweight men demonstrated that olive leaf extract significantly improved insulin sensitivity and pancreatic β-cell responsiveness (de Bock et al., 2013). These findings suggest that olive leaf extract could be beneficial for individuals at risk of developing metabolic syndrome or type 2 diabetes.
Another area where olive leaf extract shows promise is in enhancing immune function and reducing inflammation. The extract's anti-inflammatory properties are due to its ability to modulate inflammatory markers and oxidative stress. Studies on animal models have shown that olive leaf extract can reduce oxidative stress markers and improve antioxidant enzyme activities, which help protect against cellular damage (Romero et al., 2016). Moreover, olive leaf extract has been found to possess antimicrobial properties, making it useful in fighting off various infections and supporting overall immune health.
Overall, the scientific evidence supports the use of olive leaf extract for cardiovascular health, blood sugar regulation, and immune system support. While more research is needed to fully understand its mechanisms and potential benefits, the existing studies provide a strong foundation for its use as a natural health supplement.
How does Olive Leaf Extract work?
Olive Leaf Extract works through several mechanisms due to its rich composition of bioactive compounds, primarily phenolic compounds like oleuropein, hydroxytyrosol, and various flavonoids. These compounds contribute to olive leaf extract's multifaceted health benefits, including its antioxidant, anti-inflammatory, and antimicrobial properties.
One of the key ways olive leaf extract exerts its effects is through its potent antioxidant activity. Oleuropein, the primary phenolic compound in olive leaf extract, has been shown to neutralize free radicals and reduce oxidative stress. This antioxidant action helps protect cells from damage caused by oxidative stress, which is linked to chronic diseases like cardiovascular disease and cancer. Studies have demonstrated that olive leaf extract can enhance the activity of enzymes such as glutathione peroxidase, which plays a crucial role in detoxifying harmful oxidative molecules (Mehraein et al., 2016).
Another important mechanism is the anti-inflammatory action of olive leaf extract. Inflammation is a natural response to injury or infection, but chronic inflammation can contribute to various diseases. Olive leaf extract has been shown to modulate inflammatory pathways by inhibiting the production of pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). This reduction in inflammatory markers can help alleviate conditions associated with chronic inflammation (Liu et al., 2014).
Olive leaf extract also impacts cardiovascular health by improving blood lipid profiles and reducing blood pressure. It enhances the expression of genes involved in cholesterol efflux, promoting the removal of excess cholesterol from the body, and thus improving lipid profiles (Farràs et al., 2018). Additionally, the vasodilatory properties of oleuropein help relax blood vessels, which can lead to reduced blood pressure. This effect is particularly beneficial for individuals with hypertension, as evidenced by studies showing significant reductions in both systolic and diastolic blood pressure following olive leaf extract supplementation (Susalit et al., 2011).
Furthermore, olive leaf extract exhibits antimicrobial properties that can help combat various infections. The phenolic compounds in the extract can disrupt the integrity of bacterial cell membranes, leading to the inhibition of bacterial growth. This antimicrobial action makes olive leaf extract a valuable natural remedy for supporting immune health and fighting off infections (Lee & Lee, 2010).
In summary, olive leaf extract works through antioxidant, anti-inflammatory, cardiovascular, and antimicrobial mechanisms, primarily driven by its rich content of phenolic compounds. These multifaceted actions contribute to its wide range of health benefits and make it a valuable natural supplement for promoting overall well-being.
How is Olive Leaf Extract used differently in men’s and women’s health?
Olive Leaf Extract offers numerous health benefits for both men and women, but certain applications may be more relevant or emphasized depending on gender-specific health concerns. While the core benefits such as cardiovascular support, blood sugar regulation, and immune enhancement apply universally, there are particular areas where olive leaf extract can be tailored to meet the unique health needs of men and women.
In men’s health, olive leaf extract is often highlighted for its cardiovascular benefits and potential in managing metabolic syndrome. Men are generally at a higher risk of developing cardiovascular diseases at a younger age compared to women, making heart health a prominent focus. Studies have shown that olive leaf extract can effectively reduce blood pressure and improve lipid profiles, which are critical factors in preventing heart disease (Lockyer et al., 2016). Additionally, olive leaf extract may help improve insulin sensitivity and glucose metabolism, which are particularly beneficial for men at risk of type 2 diabetes and metabolic syndrome (de Bock et al., 2013).
For women, olive leaf extract's anti-inflammatory and antioxidant properties are particularly beneficial in addressing conditions like osteoporosis and skin health. Women are more prone to osteoporosis, especially post-menopause, due to a decrease in estrogen levels. The antioxidant properties of olive leaf extract can help mitigate oxidative stress, which plays a role in bone density loss. Furthermore, its anti-inflammatory effects can help reduce the risk of chronic inflammatory conditions that disproportionately affect women, such as rheumatoid arthritis (Romero et al., 2016).
Skin health is another area where olive leaf extract is commonly used for women. The extract's potent antioxidants, particularly oleuropein and hydroxytyrosol, help protect the skin from oxidative damage caused by environmental factors like UV radiation and pollution. This protection can lead to improved skin elasticity and reduced signs of aging, making it a popular ingredient in skincare products (Mahmoudi et al., 2018).
Hormonal balance is also a significant concern in women’s health, particularly during menopause. Olive leaf extract may support hormonal health by reducing oxidative stress and inflammation, which can help alleviate some symptoms associated with hormonal imbalances. Although more research is needed in this area, preliminary findings suggest that the extract's anti-inflammatory properties could be beneficial in managing menopausal symptoms (Liu et al., 2014).
In summary, while olive leaf extract provides general health benefits applicable to both men and women, its use can be tailored to address specific gender-related health concerns. For men, the focus is often on cardiovascular health and metabolic syndrome, whereas for women, the emphasis is on bone health, skin health, and hormonal balance. This versatility makes olive leaf extract a valuable supplement for promoting overall health and well-being in both genders.
How much Olive Leaf Extract should I take?
Determining the optimal dosage of Olive Leaf Extract can vary depending on the specific health benefits you are seeking and the form of the extract you are using. Generally, dosages can range from 500 mg to 1,000 mg per day, but it's important to consider the concentration of active compounds like oleuropein in the product you choose.
For cardiovascular health, studies have shown that a dosage of 500 mg of olive leaf extract taken twice daily can be effective in reducing blood pressure and improving lipid profiles. For example, a study published in "Phytomedicine" found that 500 mg of olive leaf extract taken twice daily was as effective as the antihypertensive drug Captopril in lowering blood pressure in patients with stage-1 hypertension (Susalit et al., 2011). This dosage is generally well-tolerated and can provide significant benefits for heart health.
When it comes to improving insulin sensitivity and managing blood sugar levels, a dosage of around 500 mg to 1,000 mg per day is often recommended. A randomized, placebo-controlled trial involving middle-aged overweight men demonstrated that taking 500 mg of olive leaf extract twice daily for 12 weeks significantly improved insulin sensitivity and pancreatic β-cell responsiveness (de Bock et al., 2013). This suggests that a similar dosage could be beneficial for those looking to support healthy blood sugar levels.
For general antioxidant and anti-inflammatory benefits, a daily dosage of 500 mg to 1,000 mg can be effective. These doses have been shown to enhance antioxidant enzyme activities, reduce oxidative stress, and provide anti-inflammatory effects. For instance, a study on the effects of olive leaf extract on oxidative stress and inflammation found that dosages within this range significantly improved antioxidant status and reduced inflammatory markers (Romero et al., 2016).
It's important to note that individual responses to supplements can vary, and starting with a lower dose and gradually increasing it may help minimize any potential side effects. Additionally, different forms of olive leaf extract, such as capsules, tinctures, or teas, may have varying concentrations of active compounds, so following the manufacturer's dosage recommendations is advisable.
In summary, the optimal dosage of olive leaf extract generally ranges from 500 mg to 1,000 mg per day, depending on the specific health benefits you are targeting. Always consider the concentration of active compounds in the product and start with a lower dose if you are new to the supplement.
What are the main side effects of Olive Leaf Extract?
Olive Leaf Extract is generally considered safe for most people when taken in appropriate dosages, but like any supplement, it can cause side effects in some individuals. The most commonly reported side effects are mild and include gastrointestinal issues such as nausea, stomach pain, and diarrhea. These effects are usually temporary and can often be minimized by taking the extract with food.
One potential side effect that some individuals may experience is a "detox" reaction, also known as the Herxheimer reaction. This occurs when the body is rapidly detoxifying and releasing stored toxins, which can temporarily cause flu-like symptoms such as headaches, fatigue, muscle aches, and joint pain. This reaction is more common in individuals who start with a higher dose of olive leaf extract. To mitigate this, it is advisable to start with a lower dose and gradually increase it, allowing the body to adjust.
Allergic reactions, although rare, can also occur. Symptoms of an allergic reaction may include itching, rash, swelling, and difficulty breathing. If you experience any of these symptoms, it is important to discontinue use immediately and seek medical attention. People with known allergies to olives or olive products should exercise caution when taking olive leaf extract.
Another consideration is the potential for olive leaf extract to lower blood pressure. While this can be beneficial for individuals with hypertension, those with already low blood pressure or those taking medications to lower blood pressure should monitor their blood pressure levels closely. Combining olive leaf extract with other blood pressure-lowering agents could result in hypotension, characterized by symptoms such as dizziness, lightheadedness, and fainting.
Lastly, because olive leaf extract has been shown to improve insulin sensitivity and lower blood sugar levels, individuals with diabetes or those taking medications to lower blood sugar should monitor their glucose levels carefully. Adjustments to medication dosages might be necessary to avoid hypoglycemia, a condition where blood sugar levels drop too low.
In summary, while olive leaf extract is generally well-tolerated, potential side effects include gastrointestinal discomfort, detox reactions, allergic reactions, and effects on blood pressure and blood sugar levels. Starting with a lower dose and gradually increasing it, as well as monitoring your body's response, can help minimize these side effects.
Who should not take Olive Leaf Extract?
While Olive Leaf Extract is generally safe for most people, there are specific groups who should exercise caution or avoid using it altogether. Understanding these contraindications can help ensure safe and effective use of the supplement.
One group that should be cautious includes individuals with low blood pressure. Olive leaf extract has been shown to lower blood pressure, which can be beneficial for those with hypertension but could pose a risk for those already experiencing hypotension. Symptoms of hypotension include dizziness, lightheadedness, and fainting. If you have low blood pressure or are taking medications to manage blood pressure, it is advisable to consult a healthcare provider before starting olive leaf extract.
People with diabetes or those taking medications to lower blood sugar levels should also be cautious. Olive leaf extract has been found to improve insulin sensitivity and lower blood glucose levels. While this can be beneficial in managing diabetes, it may also increase the risk of hypoglycemia when combined with other blood sugar-lowering medications. Monitoring blood sugar levels closely and adjusting medication dosages as needed can help mitigate this risk.
Individuals who are pregnant or breastfeeding should avoid taking olive leaf extract unless advised otherwise by a healthcare provider. There is limited research on the safety of olive leaf extract during pregnancy and lactation, so it's best to err on the side of caution. Similarly, children should not take olive leaf extract without medical supervision due to the lack of sufficient safety data for this age group.
Those with known allergies to olives or olive products should also avoid olive leaf extract to prevent allergic reactions. Symptoms of an allergic reaction can include itching, rash, swelling, and difficulty breathing. If you experience any of these symptoms, discontinue use immediately and seek medical attention.
Lastly, individuals undergoing surgery or those with bleeding disorders should be cautious. Olive leaf extract may have blood-thinning properties, which could increase the risk of bleeding during and after surgery. It is recommended to stop taking the supplement at least two weeks before any scheduled surgical procedures and to consult with a healthcare provider if you have a bleeding disorder.
In summary, individuals with low blood pressure, diabetes, allergies to olives, those who are pregnant or breastfeeding, children, and those undergoing surgery or with bleeding disorders should exercise caution or avoid using olive leaf extract. Consulting a healthcare provider before starting the supplement can help ensure its safe and effective use.
Are Olive Leaf Extract supplements known to interact with any medications?
Yes, Olive Leaf Extract supplements are known to interact with certain medications, and it is crucial to be aware of these potential interactions to ensure safety and efficacy. These interactions are primarily due to the extract's effects on blood pressure, blood sugar levels, and its potential blood-thinning properties.
One of the most notable interactions is with blood pressure medications. Olive leaf extract has been shown to lower blood pressure, which can be beneficial for individuals with hypertension. However, when combined with antihypertensive drugs, there is a risk of blood pressure dropping too low, leading to hypotension. Symptoms of hypotension include dizziness, lightheadedness, and fainting. If you are taking medications such as ACE inhibitors, beta-blockers, or diuretics, it is essential to monitor your blood pressure closely and consult with a healthcare provider before starting olive leaf extract.
Another significant interaction is with blood sugar-lowering medications. Olive leaf extract has been found to improve insulin sensitivity and reduce blood glucose levels. While this can aid in managing diabetes, it may also increase the risk of hypoglycemia when taken alongside medications like insulin or oral hypoglycemics (e.g., metformin, sulfonylureas). Monitoring blood sugar levels and adjusting medication dosages accordingly can help mitigate this risk. It is advisable to consult with a healthcare provider before combining olive leaf extract with any blood sugar-lowering drugs.
Olive leaf extract may also interact with anticoagulant and antiplatelet medications. The extract has potential blood-thinning properties, which could enhance the effects of drugs like warfarin, aspirin, and clopidogrel. This interaction could increase the risk of bleeding and bruising. If you are taking any blood-thinning medications, it is crucial to seek medical advice before adding olive leaf extract to your regimen to avoid complications.
Additionally, olive leaf extract could interact with medications metabolized by the liver's cytochrome P450 enzyme system. This system is responsible for the metabolism of various drugs, and compounds in olive leaf extract may inhibit or induce these enzymes, potentially altering the effectiveness and concentration of certain medications. Examples include statins, certain antidepressants, and some antiepileptic drugs. Consulting a healthcare provider is advisable if you are taking medications that are metabolized by this enzyme system.
In summary, olive leaf extract supplements can interact with blood pressure medications, blood sugar-lowering drugs, anticoagulants, antiplatelet medications, and drugs metabolized by the cytochrome P450 enzyme system. To ensure safety and avoid adverse effects, it is essential to consult with a healthcare provider before combining olive leaf extract with any prescription medications.
What are the best sources of Olive Leaf Extract?
When selecting the best sources of Olive Leaf Extract, it is essential to consider factors such as the quality of the raw materials, the extraction methods used, and the concentration of active compounds like oleuropein. Here are some tips to identify high-quality olive leaf extract supplements:
- Reputable Brands: Choose products from reputable manufacturers known for their stringent quality control measures and transparent labeling practices. Brands with a history of producing high-quality supplements are more likely to offer effective and safe olive leaf extract products. Look for companies that provide detailed information about their sourcing, manufacturing processes, and third-party testing.
- Organic and sustainably sourced: Opt for olive leaf extracts sourced from organic and sustainably grown olive trees. Organic farming practices reduce the risk of pesticide and chemical contamination, ensuring a purer product. Additionally, sustainable sourcing practices help protect the environment and support local communities where the olive trees are cultivated.
- Standardized Extracts: Ensure that the supplement you choose is standardized to contain a specific percentage of oleuropein, the primary active compound in olive leaf extract. Standardization guarantees a consistent and potent product. A common standardization is to 20% oleuropein, but some high-quality products may contain even higher concentrations.
- Extraction Methods: The extraction method used can significantly impact the quality and potency of the final product. Look for olive leaf extracts that use gentle extraction methods, such as water or ethanol extraction, which preserve the integrity of the active compounds. Avoid products that use harsh chemical solvents, as these can leave residues and degrade the extract's quality.
- Third-Party Testing: Choose products that have undergone third-party testing for purity, potency, and safety. Independent testing laboratories verify that the supplement contains the stated ingredients and is free from contaminants such as heavy metals, pesticides, and microbial impurities. Look for supplements with a certificate of analysis (COA) available upon request.
- Transparent Labeling: High-quality olive leaf extract supplements should have clear and transparent labeling, providing detailed information about the ingredients, concentration of active compounds, recommended dosage, and any potential allergens. Transparent labeling helps you make informed decisions and ensures you are getting a product that meets your needs.
Some reputable brands known for producing high-quality olive leaf extract supplements include Gaia Herbs, NOW Foods, and Barlean's. These brands are recognized for their commitment to quality, transparency, and sustainable sourcing practices.
In summary, the best sources of olive leaf extract come from reputable brands that use organic and sustainably sourced raw materials, standardized extracts, gentle extraction methods, third-party testing, and transparent labeling. By considering these factors, you can ensure that you are getting a high-quality and effective olive leaf extract supplement.
What forms does Olive Leaf Extract come in?
Olive Leaf Extract is available in various forms, catering to different preferences and lifestyles. Each form has its unique advantages and can be chosen based on convenience, specific health goals, and personal preference. Here are the most common forms of olive leaf extract:
- Capsules and Tablets: Capsules and tablets are among the most popular forms of olive leaf extract. They are convenient, easy to dose, and portable, making them ideal for individuals with busy lifestyles. Capsules and tablets typically come in standardized doses, ensuring a consistent intake of active compounds like oleuropein. They are also a good option for those who prefer a tasteless form of supplementation.
- Liquid Extracts and Tinctures: Liquid extracts and tinctures are concentrated solutions of olive leaf extract. These forms are absorbed more quickly by the body compared to capsules and tablets, which can be advantageous for individuals seeking rapid effects. Liquid extracts and tinctures offer flexible dosing, as they can be easily adjusted by altering the number of drops taken. They can be mixed with water, juice, or other beverages for easier consumption. However, some people might find the taste of liquid extracts and tinctures to be strong or bitter.
- Powdered Extracts: Powdered extracts are another versatile form of olive leaf extract. They can be mixed into smoothies, shakes, or other beverages, and can also be added to foods like yogurt or oatmeal. This form is ideal for individuals who prefer to incorporate their supplements into their daily meals or those who have difficulty swallowing capsules or tablets. Powdered extracts often come in bulk containers, allowing for customized dosing.
- Teas: Olive leaf tea is a traditional form of olive leaf extract that has been used for centuries in Mediterranean cultures. The leaves are dried and then steeped in hot water to create a soothing and healthful beverage. Olive leaf tea provides a more natural and less processed way to consume the extract, and it can be enjoyed as part of a daily routine. However, the concentration of active compounds in tea may be lower compared to other forms of supplementation.
- Topical Applications: Olive leaf extract is also available in topical forms, such as creams, lotions, and ointments. These products are designed for external use and can be applied directly to the skin. Topical applications are often used for their antioxidant and anti-inflammatory properties, making them beneficial for skin health, wound healing, and reducing inflammation. They can be particularly useful for addressing skin conditions like eczema, psoriasis, and acne.
Each form of olive leaf extract offers its own set of advantages, and the choice of form will depend on individual preferences and specific health goals. Whether you prefer the convenience of capsules, the rapid absorption of liquid extracts, the versatility of powdered extracts, the traditional appeal of teas, or the targeted application of topicals, there is a form of olive leaf extract to suit your needs.
Which sub-compounds of Olive Leaf Extract, if any, are critical to the efficacy of Olive Leaf Extract?
Olive Leaf Extract derives its efficacy from a variety of bioactive compounds, each contributing to its overall health benefits. Among these, a few key sub-compounds are particularly critical due to their potent biological activities. Understanding these compounds helps to appreciate the multifaceted benefits of olive leaf extract.
- Oleuropein: Oleuropein is the most studied and prominent compound in olive leaf extract. It is a type of polyphenol known for its strong antioxidant, anti-inflammatory, and antimicrobial properties. Oleuropein has been shown to protect LDL cholesterol from oxidation, reduce blood pressure, and improve lipid profiles, making it particularly beneficial for cardiovascular health (Castañer et al., 2012). It also exhibits antiviral and antibacterial activities, contributing to immune system support (Lee & Lee, 2010). Its ability to modulate inflammatory pathways further enhances its potential in managing chronic inflammatory conditions.
- Hydroxytyrosol: Hydroxytyrosol is another important phenolic compound found in olive leaf extract. It is one of the most powerful natural antioxidants, even more potent than vitamin C and E. Hydroxytyrosol plays a significant role in neutralizing free radicals and reducing oxidative stress. This compound has been associated with various health benefits, including cardiovascular protection, anti-cancer properties, and neuroprotection. Studies have shown that hydroxytyrosol can improve endothelial function, reduce inflammation, and enhance lipid metabolism (Mahmoudi et al., 2018).
- Tyrosol: Tyrosol is a phenolic compound that, while less potent than hydroxytyrosol, still contributes to the antioxidant and anti-inflammatory properties of olive leaf extract. Tyrosol has been shown to protect cells from oxidative damage and support cardiovascular health. It works synergistically with other phenolic compounds to enhance the overall efficacy of olive leaf extract (Farràs et al., 2018).
- Flavonoids: Olive leaf extract contains various flavonoids, such as apigenin, luteolin, and rutin. These compounds exhibit antioxidant, anti-inflammatory, and anticancer properties. Flavonoids help to scavenge free radicals, reduce oxidative stress, and modulate inflammatory pathways. They also contribute to the antimicrobial activities of olive leaf extract, enhancing its ability to fight infections (Lee & Lee, 2010).
- Secoiridoids: Secoiridoids, including oleacein and oleocanthal, are another group of compounds found in olive leaf extract. These compounds have been shown to possess strong anti-inflammatory and antioxidant properties. Oleocanthal, in particular, has been compared to ibuprofen for its anti-inflammatory effects, making it a valuable component in managing pain and inflammation (Castañer et al., 2012).
These critical sub-compounds work synergistically to provide the comprehensive health benefits associated with olive leaf extract. While oleuropein and hydroxytyrosol are often highlighted for their potent effects, the combined action of all these bioactive compounds contributes to the extract's overall efficacy. When choosing an olive leaf extract supplement, it is beneficial to look for products that specify the concentrations of these key compounds, particularly oleuropein and hydroxytyrosol, to ensure maximum effectiveness.
What is Olive Leaf Extract also known as?
Olive Leaf Extract is known by several names and terms, reflecting its use in various contexts and formulations. Here are some of the most common names, abbreviations, and related terms:
- Scientific and Common Names:
- Olea europaea: This is the scientific name for the olive tree from which the leaves are harvested.
- Olive Leaf Extract: The most straightforward and common name for the supplement.
- Chemical Compounds and Ingredients:
- Oleuropein: The primary active compound in olive leaf extract, known for its potent antioxidant and anti-inflammatory properties.
- Hydroxytyrosol: Another key phenolic compound found in olive leaf extract, renowned for its strong antioxidant capabilities.
- Tyrosol: A phenolic compound that contributes to the extract's antioxidant and anti-inflammatory effects.
- Flavonoids: A group of compounds in the extract, including apigenin, luteolin, and rutin, which provide additional antioxidant and anti-inflammatory benefits.
- Secoiridoids: Compounds like oleacein and oleocanthal, known for their anti-inflammatory properties.
- Abbreviations:
- OLE: A common abbreviation for Olive Leaf Extract.
- O. europaea: An abbreviation for the scientific name of the olive tree.
- Common Misspellings and Variants:
- Olive Leaf Exctract: A common misspelling with the letters "t" and "r" transposed.
- Olive Leaf Extact: A misspelling omitting the "r" in "extract."
- Olive Leave Extract: A misspelling that uses "leave" instead of "leaf."
- Other Related Terms:
- Virgin Olive Leaf Extract: Sometimes used to denote a high-quality, minimally processed form of the extract.
- Organic Olive Leaf Extract: Indicates that the extract is sourced from organically grown olive trees.
- Product Names and Formulations:
- Olive Leaf Tea: A traditional form of olive leaf extract prepared as a tea.
- Olive Leaf Tincture: A liquid extract of olive leaves, often used for its rapid absorption.
- Olive Leaf Capsules/Tablets: Encapsulated or tablet forms of the extract, commonly available as dietary supplements.
Understanding these various names and terms can help you identify and select the right product when shopping for olive leaf extract supplements. Whether you encounter it as "OLE," "Olea europaea," or under specific product names, the core benefits and active compounds remain consistent.
What is important to look for on the label of a Olive Leaf Extract supplement to ensure product quality?
When selecting an Olive Leaf Extract supplement, it is crucial to carefully examine the product label to ensure you are purchasing a high-quality and effective product. Here are some key factors to look for on the label:
- Standardization of Active Compounds:
- Oleuropein Content: The label should specify the concentration of oleuropein, the primary active compound in olive leaf extract. A common standardization is 20% oleuropein, but higher concentrations are also available. Standardization ensures that you are getting a consistent and potent dose of the active ingredient.
- Other Phenolic Compounds: Some labels may also indicate the presence and concentrations of other important phenolic compounds such as hydroxytyrosol and tyrosol. These compounds contribute to the extract's overall efficacy.
- Extraction Method:
- Extraction Process: The label should mention the extraction method used. Look for extracts obtained using gentle methods like water or ethanol extraction, which preserve the integrity of the active compounds. Avoid products that use harsh chemical solvents, as these can leave residues and degrade the extract's quality.
- Purity and Additives:
- No Fillers or Additives: Check that the supplement is free from unnecessary fillers, binders, or artificial additives. High-quality products will have minimal additional ingredients, ensuring you receive a pure and effective extract.
- Allergen Information: Ensure the product is free from common allergens if you have specific sensitivities. The label should clearly state whether the supplement is free from gluten, dairy, soy, etc.
- Organic and Sustainable Sourcing:
- Organic Certification: If possible, choose products that are certified organic. Organic certification ensures that the olive leaves were grown without the use of harmful pesticides or synthetic fertilizers.
- Sustainable Practices: Some labels may indicate whether the product is sustainably sourced, supporting environmentally friendly farming practices and ethical production.
- Third-Party Testing and Certification:
- Third-Party Testing: Look for supplements that have been tested by independent laboratories for purity, potency, and safety. Third-party testing can provide assurance that the product contains the stated ingredients and is free from contaminants such as heavy metals, pesticides, and microbial impurities.
- Certificates of Analysis (COA): Reputable brands often provide a Certificate of Analysis, which details the results of third-party testing. This document may be available on the company's website or upon request.
- Dosage Information:
- Recommended Dosage: The label should provide clear instructions on the recommended dosage and how to take the supplement. This information helps ensure you are consuming the supplement safely and effectively.
- Serving Size: Check the serving size to understand how much of the active compounds you will be consuming per dose.
- Manufacturer Information:
- Reputable Manufacturer: Ensure the supplement is produced by a reputable manufacturer known for high-quality products. The label should include the manufacturer's name, contact information, and location.
- Good Manufacturing Practices (GMP): Look for indications that the product is manufactured in a facility that follows Good Manufacturing Practices. GMP certification ensures that the product is produced under strict quality control standards.
In summary, when choosing an olive leaf extract supplement, look for labels that provide clear information on the standardization of active compounds, extraction methods, purity, organic certification, third-party testing, dosage instructions, and reputable manufacturing practices. These factors can help you select a high-quality product that delivers the desired health benefits.
Disclaimer & References
The information provided on this website, including any text, images, or other material contained within, is for informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. This page was created by the SuppCo editiorial team, with AI summarization tools, including data from but not limited to following studies:
- S. Lockyer, I. Rowland, J. Spencer, P. Yaqoob, W. Stonehouse (2016). Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial. European Journal of Nutrition, 56, 1421 - 1432. Link: 10.1007/s00394-016-1188-y
- Alejandra Vazquez, E. Sanchez-Rodríguez, F. Vargas, Sebastián Montoro-Molina, M. Romero, J. A. Espejo-Calvo, Pedro Vílchez, Sara Jaramillo, L. Olmo-García, A. Carrasco-Pancorbo, R. de la Torre, M. Fitó, M. Covas, E. Martínez de Victoria, M. Mesa (2019). Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats. Nutrients, 11, . Link: 10.3390/nu11081728
- M. Khayyal, M. El-Ghazaly, Dalai Abdallah, N. Nassar, S. Okpanyi, M. Kreuter (2002). Blood Pressure Lowering Effect of an Olive Leaf Extract {Olea europaed) in L-NAME Induced Hypertension in Rats. Arzneimittelforschung, 52, 797 - 802. Link: 10.1055/s-0031-1299970
- A. Fatahian, S. Yousefi, M. Azadbakht, M. Moosazadeh, M. Fakhri (2022). The effect of olive leaf use on blood pressure; A systematic review and meta-analysis. Journal of Renal Injury Prevention, , . Link: 10.34172/jrip.2022.31933
- M. Hermans, P. Lempereur, J. Salembier, Nathalie Maes, A. Albert, Olivia Jansen, J. Pincemail (2020). Supplementation Effect of a Combination of Olive (Olea europea L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic Syndrome. Antioxidants, 9, . Link: 10.3390/antiox9090872
- Rachel H X Wong, M. Garg, L. Wood, Peter R C Howe (2014). Antihypertensive Potential of Combined Extracts of Olive Leaf, Green Coffee Bean and Beetroot: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial. Nutrients, 6, 4881 - 4894. Link: 10.3390/nu6114881
- T. Perrinjaquet‐Moccetti, A. Busjahn, C. Schmidlin, Annette Schmidt, Barbara Bradl, C. Aydoğan (2008). Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytotherapy Research, 22, . Link: 10.1002/ptr.2455
- M. Romero, M. Toral, M. Gómez-Guzmán, R. Jiménez, P. Galindo, M. Sánchez, M. Olivares, J. Gálvez, J. Duarte (2016). Antihypertensive effects of oleuropein-enriched olive leaf extract in spontaneously hypertensive rats.. Food & function, 7 1,
584-93 . Link: 10.1039/c5fo01101a - Muhammad Asyraf Ismail, M. N. Norhayati, Noraini Mohamad (2021). Olive leaf extract effect on cardiometabolic profile among adults with prehypertension and hypertension: a systematic review and meta-analysis. PeerJ, 9, . Link: 10.7717/peerj.11173
- E. Susalit, Nafrialdi Agus, I. Effendi, R. Tjandrawinata, D. Nofiarny, T. Perrinjaquet‐Moccetti, M. Verbruggen (2011). Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 18 4,
251-8 . Link: 10.1016/j.phymed.2010.08.016 - Ines Fki, S. Sayadi, Asma Mahmoudi, Ines Daoued, R. Marrekchi, Héla Ghorbel (2020). Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats. BioMed Research International, 2020, . Link: 10.1155/2020/1315202
- Desirée Victoria-Montesinos, María Salud Abellán Ruiz, Antonio J. Luque Rubia, Daniel Guillén Martínez, Silvia Pérez-Piñero, Maravillas Sánchez Macarro, A. García-Muñoz, Fernando Cánovas García, Julián Castillo Sánchez, F. J. López-Román (2021). Effectiveness of Consumption of a Combination of Citrus Fruit Flavonoids and Olive Leaf Polyphenols to Reduce Oxidation of Low-Density Lipoprotein in Treatment-Naïve Cardiovascular Risk Subjects: A Randomized Double-Blind Controlled Study. Antioxidants, 10, . Link: 10.3390/antiox10040589
- H. Ahmadvand, S. Bagheri, A. Khosrobeigi, M. Boshtam, Foad Abdolahpour (2011). Effects of olive leaves extract on LDL oxidation induced-CuSO(4) in vitro.. Pakistan journal of pharmaceutical sciences, 25 3,
571-5 . Link: 10.1016/J.CLINBIOCHEM.2011.08.860 - O. Castañer, M. Covas, O. Khymenets, K. Nyyssonen, V. Konstantinidou, H. Zunft, R. de la Torre, D. Muñoz-Aguayo, J. Vila, M. Fitó (2012). Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans.. The American journal of clinical nutrition, 95 5,
1238-44 . Link: 10.3945/ajcn.111.029207 - Asma Mahmoudi, Fatma Hadrich, I. Feki, Héla Ghorbel, Z. Bouallagui, R. Marrekchi, H. Fourati, S. Sayadi (2018). Oleuropein and hydroxytyrosol rich extracts from olive leaves attenuate liver injury and lipid metabolism disturbance in bisphenol A-treated rats.. Food & function, 9 6,
3220-3234 . Link: 10.1039/c8fo00248g - J. Fonollá, J. Maldonado-Lobón, R. Luque, C. Rodríguez, O. Bañuelos, Jose L. López-Larramendi, M. Olivares, R. Blanco-Rojo (2020). Effects of a Combination of Extracts from Olive Fruit and Almonds Skin on Oxidative and Inflammation Markers in Hypercholesterolemic Subjects: A Randomized Controlled Trial. Journal of Medicinal Food, 24, 479 - 486. Link: 10.1089/jmf.2020.0088
- Karina de la Torre-Carbot, J. Chávez-Servín, O. Jáuregui, A. I. Castellote, R. Lamuela-Raventós, T. Nurmi, Henrik E. Poulsen, Antonio V. Gaddi, J. Kaikkonen, H. Zunft, H. Kiesewetter, M. Fitó, M. Covas, M. Lopez-Sabater (2010). Elevated circulating LDL phenol levels in men who consumed virgin rather than refined olive oil are associated with less oxidation of plasma LDL.. The Journal of nutrition, 140 3,
501-8 . Link: 10.3945/jn.109.112912 - Ya‐Mei Yu, Chingmin E. Tsai (2003). LDL cholesterol and oxidation are significantly reduced in Type 2 diabetic patients receiving a barley leaf essence supplemented olive oil diet. {"title"=>"", "scimago_quartile"=>nil}, 5, 1-6. Link: 10.6787/FSAC.200312.0001
- Á. Hernáez, A. Remaley, M. Farràs, Sara Fernández-Castillejo, I. Subirana, H. Schröder, Mireia Fernández-Mampel, D. Muñoz-Aguayo, M. Sampson, R. Solà, M. Farré, R. de la Torre, M. Lopez-Sabater, K. Nyyssönen, H. Zunft, M. Covas, M. Fitó (2015). Olive Oil Polyphenols Decrease LDL Concentrations and LDL Atherogenicity in Men in a Randomized Controlled Trial.. The Journal of nutrition, 145 8,
1692-7 . Link: 10.3945/jn.115.211557 - J. Marrugat, M. Covas, M. Fitó, H. Schröder, E. Miró‐Casas, E. Gimeno, M. Lopez-Sabater, R. Torre, M. Farré, and the members of the Solos Investigators (2004). Effects of differing phenolic content in dietary olive oils on lipids and LDL oxidation. European Journal of Nutrition, 43, 140-147. Link: 10.1007/S00394-004-0452-8
- M. Temi̇z, A. Temur (2019). Olive (Olea europaea L.) leaf extract boosts antioxidant status and attenuates hepatic and pancreatic changes in diabetic rats. Applied Biological Research, , . Link: 10.5958/0974-4517.2019.00002.8
- J. Giacometti, Tanja Grubić-Kezele (2020). Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity. Oxidative Medicine and Cellular Longevity, 2020, . Link: 10.1155/2020/6125638
- Reyes Benot-Dominguez, M. Tupone, V. Castelli, M. d’Angelo, E. Benedetti, Massimiliano Quintiliani, B. Cinque, I. Forte, M. Cifone, R. Ippoliti, B. Barboni, A. Giordano, A. Cimini (2020). Olive leaf extract impairs mitochondria by pro-oxidant activity in MDA-MB-231 and OVCAR-3 cancer cells.. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 134,
111139 . Link: 10.1016/j.biopha.2020.111139 - P. G. Lins, Silvana Marina Piccoli Pugine, A. M. Scatolini, M. P. de Melo (2018). In vitro antioxidant activity of olive leaf extract (Olea europaea L.) and its protective effect on oxidative damage in human erythrocytes. Heliyon, 4, . Link: 10.1016/j.heliyon.2018.e00805
- Hamid Rajabiesterabadi, A. Ghelichi, S. Jorjani, Seyyed Morteza Hoseini, R. Akrami (2020). Dietary olive (Olea europaea) leaf extract suppresses oxidative stress and modulates intestinal expression of antioxidant- and tight junction-related genes in common carp (Cyprinus carpio). Aquaculture, 520, 734676. Link: 10.1016/j.aquaculture.2019.734676
- F. Mehraein, Maryam Sarbishegi, Zoleikha Golipoor (2016). Different effects of olive leaf extract on antioxidant enzyme activities in midbrain and dopaminergic neurons of Substantia Nigra in young and old rats.. Histology and histopathology, 31 4,
425-31 . Link: 10.14670/HH-11-687 - Y. Sueishi, Risako Nii (2020). A comparative study of the antioxidant profiles of olive fruit and leaf extracts against five reactive oxygen species as measured with a multiple free-radical scavenging method.. Journal of food science, , . Link: 10.1111/1750-3841.15388
- O. Lee, Boo-Yong Lee (2010). Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract.. Bioresource technology, 101 10,
3751-4 . Link: 10.1016/j.biortech.2009.12.052 - K. Vasilopoulou, G. Papadopoulos, S. Lioliopoulou, Ioanna Pyrka, N. Nenadis, S. Savvidou, George K. Symeon, V. Dotas, Ioannis Panitsidis, Georgios Arsenos, I. Giannenas (2023). Effects of Dietary Supplementation of a Resin-Purified Aqueous-Isopropanol Olive Leaf Extract on Meat and Liver Antioxidant Parameters in Broilers. Antioxidants, 12, . Link: 10.3390/antiox12091723
- K. Omagari, Shigeko Kato, K. Tsuneyama, Hideki Hatta, Miki Sato, Mizuho Hamasaki, Yukiko Sadakane, Takehiro Tashiro, Mitsue Fukuhata, Y. Miyata, Shizuka Tamaru, Kazunari Tanaka, M. Mune (2010). Olive leaf extract prevents spontaneous occurrence of non‐alcoholic steatohepatitis in SHR/NDmcr‐cp rats. Pathology, 42, 66–72. Link: 10.3109/00313020903434389
- N. Angelopoulos, R. Paparodis, I. Androulakis, A. Boniakos, P. Anagnostis, V. Tsimihodimos, S. Livadas (2022). Efficacy and Safety of Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts in Improving Lipid Profile of Patients with Mild-to-Moderate Hypercholesterolemia: A Self-Control Study. Nutraceuticals, , . Link: 10.3390/nutraceuticals3010001
- M. Farràs, Sara Fernández-Castillejo, Laura Rubió, S. Arranz, Úrsula Catalán, I. Subirana, M. Romero, O. Castañer, A. Pedret, G. Blanchart, D. Muñoz-Aguayo, H. Schröder, M. Covas, R. de la Torre, M. Motilva, R. Solà, M. Fitó (2018). Phenol-enriched olive oils improve HDL antioxidant content in hypercholesterolemic subjects. A randomized, double-blind, cross-over, controlled trial.. The Journal of nutritional biochemistry, 51,
99-104 . Link: 10.1016/j.jnutbio.2017.09.010 - Anaka Ogochukwu Ngozi, Owolabi Omonkhelin Josephine, Emenike Chinwendu, Felicity (2013). Anti-hyperlipidemic effect of aqueous leaf extract of Emilia praetermissa milne-redh (Asteraceae) in rats. International Journal of Biosciences, 3, 68-77. Link: 10.12692/ijb/3.5.68-77
- M. Farràs, R. Valls, Sara Fernández-Castillejo, M. Giralt, R. Solà, I. Subirana, M. Motilva, V. Konstantinidou, M. Covas, M. Fitó (2013). Olive oil polyphenols enhance the expression of cholesterol efflux related genes in vivo in humans. A randomized controlled trial.. The Journal of nutritional biochemistry, 24 7,
1334-9 . Link: 10.1016/j.jnutbio.2012.10.008 - Á. Hernáez, Sara Fernández-Castillejo, M. Farràs, Úrsula Catalán, I. Subirana, R. Montes, R. Solà, D. Muñoz-Aguayo, Anna Gelabert-Gorgues, Óscar Díaz-Gil, K. Nyyssönen, H. Zunft, R. de la Torre, S. Martín-Peláez, A. Pedret, A. Remaley, M. Covas, M. Fitó (2014). Olive Oil Polyphenols Enhance High-Density Lipoprotein Function in Humans: A Randomized Controlled Trial. Arteriosclerosis, Thrombosis, and Vascular Biology, 34, 2115–2119. Link: 10.1161/ATVBAHA.114.303374
- Hedya Jemai, M. Bouaziz, Ines Fki, Abdel Fettah El Feki, S. Sayadi (2008). Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves.. Chemico-biological interactions, 176 2-3,
88-98 . Link: 10.1016/j.cbi.2008.08.014 - Á. Hernáez, O. Castañer, R. Elosúa, X. Pintó, R. Estruch, J. Salas‐Salvadó, D. Corella, F. Arós, L. Serra-Majem, M. Fiol, M. Ortega-Calvo, E. Ros, M. Martínez-González, R. de la Torre, M. Lopez-Sabater, M. Fitó (2017). Mediterranean Diet Improves High-Density Lipoprotein Function in High-Cardiovascular-Risk Individuals: A Randomized Controlled Trial. Circulation, 135, 633–643. Link: 10.1161/CIRCULATIONAHA.116.023712
- Lihui Wang, Cheng-yan Geng, Liping Jiang, D. Gong, Dayu Liu, H. Yoshimura, L. Zhong (2008). The anti-atherosclerotic effect of olive leaf extract is related to suppressed inflammatory response in rabbits with experimental atherosclerosis. European Journal of Nutrition, 47, 235-243. Link: 10.1007/s00394-008-0717-8
- M. Farràs, S. Arranz, S. Carrión, I. Subirana, D. Muñoz-Aguayo, G. Blanchart, Marjon Kool, R. Solà, M. Motilva, J. Escolà-Gil, Laura Rubió, Sara Fernández-Castillejo, A. Pedret, R. Estruch, M. Covas, M. Fitó, Á. Hernáez, O. Castañer (2019). A Functional Virgin Olive Oil Enriched with Olive Oil and Thyme Phenolic Compounds Improves the Expression of Cholesterol Efflux-Related Genes: A Randomized, Crossover, Controlled Trial. Nutrients, 11, . Link: 10.3390/nu11081732
- Á. Hernáez, M. Farràs, M. Fitó (2016). Olive oil phenolic compounds and high-density lipoprotein function. Current Opinion in Lipidology, 27, 47–53. Link: 10.1097/MOL.0000000000000261
- M. D. de Bock, J. Derraik, C. Brennan, Janene B. Biggs, Philip E. Morgan, S. Hodgkinson, P. Hofman, W. Cutfield (2013). Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial. PLoS ONE, 8, . Link: 10.1371/journal.pone.0057622
- Fatma Hadrich, Asma Mahmoudi, M. Chamkha, H. Isoda, S. Sayadi (2023). Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway. Oxidative Medicine and Cellular Longevity, 2023, . Link: 10.1155/2023/6828230
- Yanan Liu, Ji-Hye Jung, Hyunjin Park, Hyunsook Kim (2014). Olive leaf extract suppresses messenger RNA expression of proinflammatory cytokines and enhances insulin receptor substrate 1 expression in the rats with streptozotocin and high-fat diet-induced diabetes.. Nutrition research, 34 5,
450-7 . Link: 10.1016/j.nutres.2014.04.007 - A. A. Al-Shudiefat, Hadeel Alturk, Hamzeh J. Al-Ameer, M. Zihlif, M. Alenazy (2023). Olive Leaf Extract of Olea europaea Reduces Blood Glucose Level through Inhibition of AS160 in Diabetic Rats. Applied Sciences, , . Link: 10.3390/app13105939
- A. Al-Attar, Fawziah A. Alsalmi (2017). Effect of Olea europaea leaves extract on streptozotocin induced diabetes in male albino rats. Saudi Journal of Biological Sciences, 26, 118 - 128. Link: 10.1016/j.sjbs.2017.03.002
- A. Koçyiğit, B. Kasap, E. Guler, H. N. Kaleli, Mustafa Kesmen, M. Dikilitas, Ersin Karataş (2019). An Optimum Dose of Olive Leaf Extract Improves Insulin Receptor Substrate-1, Tyrosine Kinase, and Glucose Transporters, While High Doses Have Genotoxic and Apoptotic Effects. American Journal of Plant Sciences, , . Link: 10.4236/ajps.2019.1011136
- J. Wainstein, Tali Ganz, M. Boaz, Y. Bar Dayan, E. Dolev, Z. Kerem, Z. Madar (2012). Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats.. Journal of medicinal food, 15 7,
605-10 . Link: 10.1089/jmf.2011.0243 - D. González-Hedström, M. de la Fuente-Fernández, T. Priego, A. Martín, S. Amor, A. López-Calderón, A. M. Inarejos-García, A. Garcı́a-Villalón, M. Granado (2021). Addition of Olive Leaf Extract to a Mixture of Algae and Extra Virgin Olive Oils Decreases Fatty Acid Oxidation and Synergically Attenuates Age-Induced Hypertension, Sarcopenia and Insulin Resistance in Rats. Antioxidants, 10, . Link: 10.3390/antiox10071066
- A. Cumaoğlu, L. Račková, M. Štefek, M. Kartal, P. Maechler, Ç. Karasu (2011). Effects of olive leaf polyphenols against H₂O₂ toxicity in insulin secreting β-cells.. Acta biochimica Polonica, 58 1,
45-50 . Link: 10.18388/ABP.2011_2284 - D. González-Hedström, T. Priego, S. Amor, M. de la Fuente-Fernández, A. Martín, A. López-Calderón, A. M. Inarejos-García, A. Garcı́a-Villalón, M. Granado (2021). Olive Leaf Extract Supplementation to Old Wistar Rats Attenuates Aging-Induced Sarcopenia and Increases Insulin Sensitivity in Adipose Tissue and Skeletal Muscle. Antioxidants, 10, . Link: 10.3390/antiox10050737
- Hamid Rajabiesterabadi, A. Ghelichi, S. Jorjani, Seyyed Morteza Hoseini, R. Akrami (2020). Dietary olive (Olea europaea) leaf extract suppresses oxidative stress and modulates intestinal expression of antioxidant- and tight junction-related genes in common carp (Cyprinus carpio). Aquaculture, 520, 734676. Link: 10.1016/j.aquaculture.2019.734676
- Hedya Jemai, M. Bouaziz, Ines Fki, Abdel Fettah El Feki, S. Sayadi (2008). Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves.. Chemico-biological interactions, 176 2-3,
88-98 . Link: 10.1016/j.cbi.2008.08.014 - G. Difonzo, A. Pasqualone, R. Silletti, Lucrezia Cosmai, C. Summo, V. M. Paradiso, F. Caponio (2018). Use of olive leaf extract to reduce lipid oxidation of baked snacks.. Food research international, 108,
48-56 . Link: 10.1016/j.foodres.2018.03.034 - D. González-Hedström, M. de la Fuente-Fernández, T. Priego, A. Martín, S. Amor, A. López-Calderón, A. M. Inarejos-García, A. Garcı́a-Villalón, M. Granado (2021). Addition of Olive Leaf Extract to a Mixture of Algae and Extra Virgin Olive Oils Decreases Fatty Acid Oxidation and Synergically Attenuates Age-Induced Hypertension, Sarcopenia and Insulin Resistance in Rats. Antioxidants, 10, . Link: 10.3390/antiox10071066
- Hassan A. Elgebaly, Nermeen M. Mosa, M. Allach, K. El-massry, A. El-Ghorab, Amir M. Al Hroob, A. Mahmoud (2018). Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative stress, inflammation and apoptosis.. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 98,
446-453 . Link: 10.1016/j.biopha.2017.12.101 - J. Hayes, V. Stepanyan, P. Allen, M. O’Grady, N. O'Brien, J. Kerry (2009). The effect of lutein, sesamol, ellagic acid and olive leaf extract on lipid oxidation and oxymyoglobin oxidation in bovine and porcine muscle model systems.. Meat science, 83 2,
201-8 . Link: 10.1016/j.meatsci.2009.04.019 - Tacconi S, Longo S, Guerra F, Moliteni C, Friuli M, R. A., Gaetani S, Paradiso V M, Difonzo G, Caponio F, Lofrumento D, Vergara D, Bucci C, Dini L, Giudetti A M (2023). An aqueous olive leaf extract (OLE) ameliorates parameters of oxidative stress associated with lipid accumulation and induces lipophagy in human hepatic cells.. Food & function, , . Link: 10.1039/d3fo00817g
- E. Botsoglou, A. Govaris, I. Ambrosiadis, D. Fletouris, G. Papageorgiou (2014). Effect of olive leaf (Olea europea L.) extracts on protein and lipid oxidation in cooked pork meat patties enriched with n-3 fatty acids.. Journal of the science of food and agriculture, 94 2,
227-34 . Link: 10.1002/jsfa.6236 - Danijela Karanović, N. Mihailović-Stanojević, Z. Miloradović, M. Ivanov, Una-Jovana Vajić, J. Grujić-Milanović, J. Marković-Lipkovski, D. Dekanski, D. Jovović (2020). Olive leaf extract attenuates adriamycin‐induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis. Phytotherapy Research, 35, 1534 - 1545. Link: 10.1002/ptr.6920
- Asma Mahmoudi, Fatma Hadrich, I. Feki, Héla Ghorbel, Z. Bouallagui, R. Marrekchi, H. Fourati, S. Sayadi (2018). Oleuropein and hydroxytyrosol rich extracts from olive leaves attenuate liver injury and lipid metabolism disturbance in bisphenol A-treated rats.. Food & function, 9 6,
3220-3234 . Link: 10.1039/c8fo00248g - Desirée Victoria-Montesinos, María Salud Abellán Ruiz, Antonio J. Luque Rubia, Daniel Guillén Martínez, Silvia Pérez-Piñero, Maravillas Sánchez Macarro, A. García-Muñoz, Fernando Cánovas García, Julián Castillo Sánchez, F. J. López-Román (2021). Effectiveness of Consumption of a Combination of Citrus Fruit Flavonoids and Olive Leaf Polyphenols to Reduce Oxidation of Low-Density Lipoprotein in Treatment-Naïve Cardiovascular Risk Subjects: A Randomized Double-Blind Controlled Study. Antioxidants, 10, . Link: 10.3390/antiox10040589
- R. Leenen, A. Roodenburg, M. N. Vissers, J. A. Schuurbiers, K. P. Van Putte, S. Wiseman, F. H. van de Put (2002). Supplementation of plasma with olive oil phenols and extracts: influence on LDL oxidation.. Journal of agricultural and food chemistry, 50 5,
1290-7 . Link: 10.1021/JF010968U - Lihui Wang, Cheng-yan Geng, Liping Jiang, D. Gong, Dayu Liu, H. Yoshimura, L. Zhong (2008). The anti-atherosclerotic effect of olive leaf extract is related to suppressed inflammatory response in rabbits with experimental atherosclerosis. European Journal of Nutrition, 47, 235-243. Link: 10.1007/s00394-008-0717-8
- Karina de la Torre-Carbot, J. Chávez-Servín, O. Jáuregui, A. I. Castellote, R. Lamuela-Raventós, M. Fitó, M. Covas, D. Muñoz-Aguayo, M. Lopez-Sabater (2007). Presence of virgin olive oil phenolic metabolites in human low density lipoprotein fraction: determination by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.. Analytica chimica acta, 583 2,
402-10 . Link: 10.1016/J.ACA.2006.10.029 - María González-Santiago, J. Fonollá, E. López-Huertas (2010). Human absorption of a supplement containing purified hydroxytyrosol, a natural antioxidant from olive oil, and evidence for its transient association with low-density lipoproteins.. Pharmacological research, 61 4,
364-70 . Link: 10.1016/j.phrs.2009.12.016 - E. Olmez, K. Vural, S. Gok, Z. Ozturk, H. Kayalar, S. Ayhan, A. Var (2015). Olive Leaf Extract Improves the Atherogenic Lipid Profile in Rats Fed a High Cholesterol Diet. Phytotherapy Research, 29, 1652 - 1657. Link: 10.1002/ptr.5445
- Donatella Caruso, B. Berra, F. Giavarini, N. Cortesi, E. Fedeli, G. Galli (1999). Effect of virgin olive oil phenolic compounds on in vitro oxidation of human low density lipoproteins.. Nutrition, metabolism, and cardiovascular diseases : NMCD, 9 3,
102-7 . Link: - J. Fonollá, J. Maldonado-Lobón, R. Luque, C. Rodríguez, O. Bañuelos, Jose L. López-Larramendi, M. Olivares, R. Blanco-Rojo (2020). Effects of a Combination of Extracts from Olive Fruit and Almonds Skin on Oxidative and Inflammation Markers in Hypercholesterolemic Subjects: A Randomized Controlled Trial. Journal of Medicinal Food, 24, 479 - 486. Link: 10.1089/jmf.2020.0088
- C. Lammi, M. Bellumori, L. Cecchi, Martina Bartolomei, Carlotta Bollati, M. L. Clodoveo, F. Corbo, A. Arnoldi, N. Mulinacci (2020). Extra Virgin Olive Oil Phenol Extracts Exert Hypocholesterolemic Effects through the Modulation of the LDLR Pathway: In Vitro and Cellular Mechanism of Action Elucidation. Nutrients, 12, . Link: 10.3390/nu12061723
- H. Ahmadvand, S. Bagheri, A. Khosrobeigi, M. Boshtam, Foad Abdolahpour (2011). Effects of olive leaves extract on LDL oxidation induced-CuSO(4) in vitro.. Pakistan journal of pharmaceutical sciences, 25 3,
571-5 . Link: 10.1016/J.CLINBIOCHEM.2011.08.860
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