Nattokinase is a naturally occurring enzyme that is derived from a traditional Japanese food known as Nattō. Nattō is made by fermenting boiled soybeans with a specific type of bacteria called Bacillus subtilis. This fermentation process not only gives Nattō its unique, somewhat pungent flavor and sticky texture but also leads to the production of Nattokinase, an enzyme that has garnered interest for its potential health benefits.

Nattokinase has been recognized primarily for its fibrinolytic activity, meaning it can break down fibrin, a protein involved in blood clot formation. This property makes Nattokinase an intriguing subject for research, particularly in the context of cardiovascular health. The enzyme has been studied for its potential to support the body's natural processes in maintaining healthy blood flow by aiding in the dissolution of blood clots.

Despite its promising attributes, Nattokinase is relatively under-researched compared to other supplements. Most of the available studies have been conducted in vitro (in a laboratory setting) or in animal models, with a smaller number of human trials. As a result, while the preliminary findings are encouraging, more rigorous, large-scale clinical trials are needed to fully understand the extent of its benefits and the optimal conditions for its use.

For those interested in natural health approaches, Nattokinase offers an exciting area of exploration. However, it is important to consider the current state of research and consult with healthcare professionals before integrating it into a health regimen.

Nattokinase is primarily used for its potential cardiovascular benefits, particularly its ability to support healthy blood circulation. This enzyme is believed to help maintain optimal blood flow by breaking down fibrin, a protein that contributes to blood clot formation. By promoting fibrinolysis, Nattokinase may assist in maintaining the integrity and fluidity of the circulatory system.

Several studies have explored the potential uses of Nattokinase. A study published in the journal Hypertension Research examined the effects of Nattokinase on blood pressure. The study found that participants who consumed Nattokinase experienced a significant reduction in both systolic and diastolic blood pressure compared to a placebo group (Kim et al., 2008). These findings suggest that Nattokinase may play a role in supporting cardiovascular health by helping to manage blood pressure levels.

Another area of interest is Nattokinase's potential impact on blood clot prevention. A study in the journal Scientific Reports investigated the enzyme's effect on thrombus formation in animal models. The results indicated that Nattokinase could reduce thrombus formation, supporting its fibrinolytic activity and suggesting a possible benefit in preventing certain types of blood clots (Hsia et al., 2017).

While these studies provide promising insights, it's important to note that the body of research on Nattokinase is still growing. Many of the studies conducted so far have been preliminary, and larger, more comprehensive clinical trials involving human participants are necessary to confirm these findings and determine the appropriate applications and dosages.

In summary, Nattokinase is primarily used for its potential cardiovascular benefits, particularly in supporting healthy blood pressure and preventing blood clots. The current research is promising but still in its early stages, emphasizing the need for further investigation to fully understand the enzyme's capabilities and optimal use.

References:

• Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., ... & Lee, J. H. (2008). Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertension Research, 31(8), 1583-1588.
• Hsia, C. H., Shen, M. C., Lin, J. S., Wen, Y. K., Hwang, K. L., Cham, T. M., & Yang, N. C. (2017). Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Scientific Reports, 7(1), 17799.

Nattokinase primarily works through its potent fibrinolytic activity, which means it has the ability to break down fibrin, a protein involved in blood clot formation. The enzyme essentially mimics the body's natural mechanisms for dissolving blood clots, which is vital for maintaining healthy blood flow and preventing conditions that arise from vascular blockages.

The process begins with Nattokinase's ability to directly degrade fibrin. Fibrin is a fibrous protein that forms a mesh-like structure essential for blood clot formation. When blood vessels are injured, fibrin works with platelets to create a clot that stops bleeding. However, excessive fibrin can contribute to undesirable blood clots, impeding blood flow and potentially leading to cardiovascular issues. Nattokinase helps to break down this excess fibrin, thereby promoting better circulation and reducing the risk of clot-related complications.

Furthermore, Nattokinase has been shown to enhance the production of endogenous fibrinolytic agents, such as plasmin. Plasmin is an enzyme that plays a crucial role in breaking down fibrin clots by cleaving the fibrin meshwork into smaller fragments. By boosting plasmin activity, Nattokinase amplifies the body's natural fibrinolytic processes, thereby supporting cardiovascular health.

Another interesting aspect of Nattokinase's mechanism involves its potential to inhibit certain pathways that lead to clot formation. For example, some studies suggest that Nattokinase may inhibit the activity of substances like plasminogen activator inhibitor-1 (PAI-1), which normally suppress the breakdown of fibrin. By inhibiting PAI-1, Nattokinase further promotes fibrinolysis and helps maintain a balanced circulatory system.

In summary, Nattokinase works through multiple pathways to support cardiovascular health. Its primary action involves breaking down fibrin directly, enhancing the activity of endogenous fibrinolytic enzymes like plasmin, and potentially inhibiting pathways that contribute to clot formation. These multifaceted mechanisms make Nattokinase a promising supplement for those looking to support healthy blood flow and overall cardiovascular function.

Nattokinase is primarily recognized for its cardiovascular benefits, and its use in both men’s and women’s health revolves largely around this central theme. However, some differences in health concerns and physiological responses between men and women could influence how Nattokinase is utilized or perceived in each group.

For men, cardiovascular health often takes center stage due to the higher prevalence of heart disease and related conditions. Nattokinase, with its fibrinolytic properties, may offer a natural way to support healthy blood flow and reduce the risk of blood clots, which are common concerns in men’s health. Research indicates that men may experience more significant improvements in certain cardiovascular markers when incorporating Nattokinase, although individual responses can vary. Additionally, men might be more focused on the enzyme’s potential benefits for blood pressure management, given the higher rates of hypertension in this demographic.

In women’s health, Nattokinase could also play a crucial role, although the focus might extend beyond just cardiovascular concerns. Women, particularly those in postmenopausal stages, face unique challenges related to hormonal changes that can impact heart health and blood circulation. The enzyme’s ability to support healthy blood flow can be beneficial during these stages. Furthermore, some research suggests that Nattokinase might help alleviate certain symptoms associated with hormonal shifts, such as those experienced during menopause, by promoting better circulation and reducing the risk of vascular issues.

It’s also worth noting that women might be more attentive to the potential benefits of Nattokinase for conditions linked to blood viscosity and circulation, such as varicose veins or menstrual discomforts. By improving blood flow and aiding in the breakdown of excess fibrin, Nattokinase could offer supportive benefits for these conditions, although more specific research is needed to fully understand its effects in these contexts.

In summary, while Nattokinase is primarily used for its cardiovascular benefits in both men and women, the specific health concerns and physiological differences between the sexes can influence its application. Men might focus more on cardiovascular health and blood pressure management, whereas women could find additional benefits related to hormonal changes and circulation issues. Each individual's health profile and needs will ultimately guide the most appropriate use of Nattokinase.

Determining the optimal dosage of Nattokinase can be somewhat challenging due to the current variability in research findings and the lack of comprehensive, large-scale clinical trials. However, based on existing studies and common practices, a general guideline has emerged for its use.

Most studies and supplement manufacturers suggest a dosage range of around 100 to 200 milligrams per day, often standardized to contain approximately 2,000 to 4,000 fibrinolytic units (FU) of activity. Fibrinolytic units are a measure of the enzyme's activity level, which is a crucial factor in ensuring its efficacy. For example, a typical Nattokinase supplement might offer 100 mg of Nattokinase with 2,000 FU per capsule, taken once or twice daily.

It's important to note that individual needs and responses to Nattokinase can vary, and factors such as body weight, overall health status, and specific health goals should be taken into account. Some individuals might require a higher or lower dose to achieve the desired effects, and it's often recommended to start with the lower end of the dosage range and adjust as needed based on one's response and any guidance from a healthcare provider.

Additionally, the timing of the supplement can play a role in its effectiveness. Some practitioners recommend taking Nattokinase on an empty stomach, as food can potentially interfere with its absorption and activity. Taking the enzyme 30 minutes before meals or 2 hours after eating may help maximize its benefits.

In summary, while the typical dosage range for Nattokinase is around 100 to 200 milligrams per day, standardized to 2,000 to 4,000 fibrinolytic units, individual needs can vary. Starting with a lower dose and adjusting based on personal response and professional advice is a prudent approach. As always, consider consulting with a healthcare provider to tailor the dosage to your specific health context.

Nattokinase is generally considered safe for most people when taken at recommended doses. However, like any supplement, it can potentially cause side effects in some individuals. The majority of reported side effects are mild and transient, but it's still important to be aware of them.

One of the most commonly reported side effects of Nattokinase is gastrointestinal discomfort. Some individuals may experience symptoms such as nausea, bloating, or diarrhea, particularly when they first start taking the supplement. These symptoms are often mild and tend to diminish as the body adjusts to the enzyme.

Another potential side effect is an allergic reaction, although this is relatively rare. Symptoms of an allergic reaction can include itching, rash, or swelling, particularly if you have a known allergy to soy products, as Nattokinase is derived from fermented soybeans. If you experience any signs of an allergic reaction, it's important to discontinue use and seek medical attention.

There is also a theoretical risk of excessive bleeding with Nattokinase, given its fibrinolytic activity. By breaking down fibrin and promoting blood thinning, Nattokinase could potentially increase the risk of bleeding, especially in individuals with bleeding disorders or those taking anticoagulant medications. However, this side effect is not commonly reported and appears to be more of a concern in specific populations rather than the general public.

In summary, the main side effects of Nattokinase include gastrointestinal discomfort, possible allergic reactions, and a theoretical risk of increased bleeding. Most side effects are mild and temporary, but it's important to be mindful of them, especially if you have underlying health conditions or are taking other medications.

While Nattokinase is generally considered safe for most people, there are certain populations who should exercise caution or avoid using this supplement. Understanding who should not take Nattokinase is crucial for ensuring safety and avoiding potential complications.

Individuals with bleeding disorders or those who are at an increased risk of bleeding should avoid taking Nattokinase. This enzyme’s fibrinolytic activity, which helps break down blood clots, can potentially exacerbate bleeding tendencies. Conditions such as hemophilia, thrombocytopenia, or any other disorder that impairs normal blood clotting would make the use of Nattokinase inadvisable.

Those who are taking anticoagulant or antiplatelet medications should also avoid Nattokinase unless advised otherwise by a healthcare provider. Medications like warfarin, heparin, or even aspirin work to thin the blood and prevent clot formation. Adding Nattokinase to this regimen can increase the risk of excessive bleeding, as the combined effects could overly enhance blood thinning.

Pregnant or breastfeeding women should be cautious about using Nattokinase. There is limited research on the safety of Nattokinase during pregnancy and lactation, and its effects on the developing fetus or nursing infant are not well understood. Therefore, it is generally recommended to avoid using the supplement during these periods unless specifically advised by a healthcare professional.

Individuals who have recently undergone surgery or are scheduled for surgery should also avoid Nattokinase. The enzyme’s ability to hinder clot formation and promote fibrinolysis can interfere with normal wound healing and increase the risk of postoperative bleeding. It's advisable to discontinue the use of Nattokinase at least two weeks before any planned surgical procedure.

In summary, Nattokinase should be avoided by individuals with bleeding disorders, those taking anticoagulant or antiplatelet medications, pregnant or breastfeeding women, and those who have recently undergone or are about to undergo surgery. Consulting with a healthcare provider can help determine if Nattokinase is appropriate for your specific health situation.

Yes, Nattokinase supplements have the potential to interact with certain medications, which is an important consideration for anyone thinking about incorporating this enzyme into their health regimen. These interactions primarily revolve around the enzyme’s fibrinolytic activity and its ability to influence blood clotting and circulation.

One of the most significant interactions is with anticoagulant medications. Drugs like warfarin, heparin, and newer anticoagulants such as dabigatran, rivaroxaban, or apixaban are designed to thin the blood and prevent clot formation. Since Nattokinase also promotes blood thinning by breaking down fibrin, the combined effect of taking these medications with Nattokinase could potentially lead to an increased risk of bleeding complications. This could manifest as prolonged bleeding from cuts, easy bruising, or more serious internal bleeding events.

Antiplatelet medications, such as aspirin, clopidogrel, and ticagrelor, also pose a potential interaction risk with Nattokinase. These drugs work by inhibiting the clumping together of platelets, which is a critical step in the formation of blood clots. The fibrinolytic action of Nattokinase could enhance the effects of these antiplatelet drugs, similarly increasing the risk of bleeding.

Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen, which have a mild antiplatelet effect, might also interact with Nattokinase. While the risk may be lower compared to anticoagulants and antiplatelet drugs, the combination could still lead to an increased tendency for bleeding, especially with long-term or high-dose use.

Another area of potential interaction is with thrombolytic agents, which are medications used to dissolve existing blood clots in conditions such as stroke or myocardial infarction. Combining these powerful clot-dissolving drugs with Nattokinase could amplify their effects, again raising the risk of bleeding.

In summary, Nattokinase supplements can interact with anticoagulant medications, antiplatelet drugs, NSAIDs, and thrombolytic agents, primarily by increasing the risk of bleeding. If you are taking any of these medications, it is crucial to consult with a healthcare provider before adding Nattokinase to your regimen to ensure safe and appropriate use.

Nattokinase is most commonly derived from the traditional Japanese food Nattō, which is made by fermenting boiled soybeans with the bacterium Bacillus subtilis. Nattō itself is a rich, natural source of Nattokinase, and consuming this food can provide the enzyme along with other beneficial nutrients and probiotics.

For those who might not find Nattō appealing due to its strong flavor and sticky texture, Nattokinase is also available in supplement form. These supplements are typically standardized to ensure a specific amount of enzymatic activity, usually measured in fibrinolytic units (FU). This standardization helps ensure consistency and efficacy across different products. When selecting a Nattokinase supplement, there are a few key considerations to keep in mind to ensure you are getting a high-quality product:

1. Standardization and Potency: Look for supplements that specify the amount of Nattokinase in milligrams and the fibrinolytic activity in FU. Common dosages range from 100 to 200 mg per capsule, with an activity level of 2,000 to 4,000 FU.
2. Purity and Additives: Check the ingredient list for any unnecessary fillers, binders, or artificial additives. A high-quality supplement should contain Nattokinase as the primary ingredient, with minimal additional substances.
3. Third-Party Testing: Reputable brands often subject their products to third-party testing to verify the purity, potency, and absence of contaminants. Look for evidence of such testing on the product label or the manufacturer's website.
4. Enteric Coating: Some Nattokinase supplements come with an enteric coating to protect the enzyme from being broken down by stomach acid, ensuring it reaches the small intestine where it can be absorbed more effectively.
5. Source and Manufacturing Practices: Opt for products from reputable manufacturers who follow good manufacturing practices (GMP). This ensures that the product is produced under strict quality control standards.

In summary, the best sources of Nattokinase include the traditional food Nattō and high-quality supplements. When choosing a supplement, prioritize standardization, purity, third-party testing, enteric coating, and reputable manufacturing practices to ensure you are getting an effective and safe product.

Nattokinase is available in several forms to accommodate different preferences and needs, making it easier for individuals to incorporate this enzyme into their daily health regimen. Each form has its own advantages, and the choice often depends on personal preference, ease of use, and specific health goals. Here are the primary forms in which Nattokinase is available:

1. Capsules: Capsules are the most common form of Nattokinase supplements. They are convenient to take, easy to dose, and typically contain a standardized amount of Nattokinase, often measured in milligrams and fibrinolytic units (FU). Capsules may also come with an enteric coating to protect the enzyme from being broken down by stomach acid, ensuring it reaches the small intestine where it can be absorbed more effectively.
2. Tablets: Similar to capsules, tablets offer a precise dosage and are easy to take. Some individuals prefer tablets over capsules due to their compact size and ease of transportation. Tablets may also be enteric-coated to enhance the enzyme’s stability and absorption.
3. Powder: Nattokinase powder can be mixed with water, juice, or smoothies, making it a versatile option for those who prefer not to swallow pills. This form allows for flexible dosing and can be easily adjusted to meet individual needs. However, it may not be as convenient for on-the-go use compared to capsules or tablets.
4. Softgels: Softgel capsules are another option, often preferred for their ease of swallowing and quick disintegration in the digestive system. These may also contain oil-based formulations to enhance the stability and absorption of the enzyme.
5. Liquid Drops: Liquid Nattokinase is available in dropper bottles, offering a convenient and adjustable way to take the supplement. This form is particularly useful for those who have difficulty swallowing pills or prefer to mix the enzyme into beverages.
6. Nattō Food: For those who enjoy traditional foods, Nattō itself is a natural source of Nattokinase. Consuming Nattō provides not only the enzyme but also additional nutrients and probiotics beneficial for overall health. However, the taste and texture of Nattō can be an acquired preference.

In summary, Nattokinase is available in various forms, including capsules, tablets, powder, softgels, liquid drops, and the traditional food Nattō. The choice of form depends on individual preferences, ease of use, and specific health goals, offering flexibility to incorporate this beneficial enzyme into a daily routine.

Nattokinase itself is a specific enzyme, and its efficacy is primarily attributed to its fibrinolytic activity, which allows it to break down fibrin, a protein involved in blood clot formation. Unlike some supplements that derive their benefits from a combination of various active compounds, Nattokinase's effectiveness is largely due to the enzyme itself and its unique properties. However, understanding the enzyme's structure and function can provide insight into why it is so effective.

The active component of Nattokinase is the enzyme's protein structure, which includes specific amino acid sequences that allow it to bind to and cleave fibrin. This enzymatic activity is measured in fibrinolytic units (FU), which quantify the enzyme's ability to break down fibrin. Therefore, the potency and efficacy of a Nattokinase supplement are directly related to its FU measurement rather than the presence of additional sub-compounds.

That said, the production process and the presence of any cofactors or stabilizers can influence the enzyme's activity and stability. For instance, the fermentation process used to produce Nattokinase from Bacillus subtilis may yield minor byproducts or cofactors that could theoretically impact the enzyme's stability and function. However, these are not typically regarded as "sub-compounds" critical to the enzyme's primary activity.

Moreover, some Nattokinase supplements may include additional ingredients to enhance absorption or stability, such as enteric coatings or specific formulations that protect the enzyme from degradation in the stomach. While these do not change the enzyme's fundamental activity, they can influence how effectively the enzyme is delivered and utilized in the body.

In summary, the critical factor for the efficacy of Nattokinase is the enzyme's fibrinolytic activity, measured in fibrinolytic units (FU). There are no specific sub-compounds within Nattokinase itself that are separately critical to its efficacy. However, the production process, formulation, and presence of stabilizers can influence the enzyme's stability and effectiveness in the body.

Nattokinase is known by a few different names and abbreviations, and like many supplements, it can sometimes be subject to misspellings. Here are the various names and terms associated with Nattokinase:

1. Nattokinase: This is the most common name used.
2. Subtilisin NAT: This is the scientific name that refers to the specific enzyme derived from Bacillus subtilis during the fermentation process.
3. NK: An abbreviation often used in scientific literature and supplement labeling to refer to Nattokinase.
4. Natto extract: In some contexts, especially in traditional food supplements, the enzyme may be referred to as an extract from Nattō.
5. Nattozimes: This term sometimes appears in the context of enzyme blends that include Nattokinase, although it is not as commonly used.

Common misspellings and variations in spelling:

• Natokinase (missing one "t")
• Nato kinase (space between the words)
• Nattokinaze (incorrect ending)

Other related terms and compounds:

• Fibrinolytic enzyme: Refers to the enzyme's function in breaking down fibrin.
• Protease: A general term for enzymes that break down proteins, which Nattokinase is a type of.
• Bacillus subtilis natto: Refers to the specific strain of bacteria used to ferment soybeans to produce Nattokinase.

In summary, Nattokinase is also known as Subtilisin NAT, NK, and Natto extract, among other terms. It may be subject to common misspellings such as Natokinase, Nato kinase, and Nattokinaze. Understanding these various terms can help in identifying the enzyme across different contexts and product labels.

When choosing a Nattokinase supplement, it’s crucial to scrutinize the product label to ensure you’re getting a high-quality and effective supplement. Here are key factors to consider:

1. Standardization and Potency: Look for supplements that specify the amount of Nattokinase in milligrams (mg) and the enzyme's activity in fibrinolytic units (FU). A common dosage is 100 to 200 mg per capsule, with an activity level of 2,000 to 4,000 FU. Standardization ensures that you are getting a consistent and effective dose.
2. Enteric Coating: Since Nattokinase can be degraded by stomach acid, an enteric coating can protect the enzyme until it reaches the small intestine, where it can be absorbed effectively. Look for mention of "enteric-coated" on the label.
3. Purity and Additives: Check the ingredient list for any unnecessary fillers, binders, artificial colors, or preservatives. A high-quality supplement should contain minimal additional substances, focusing on the active enzyme.
4. Third-Party Testing: Reputable brands often submit their products to third-party testing to verify purity, potency, and the absence of contaminants. Look for certifications or seals from third-party testing organizations on the label.
5. Non-GMO and Allergen Information: For those who are health-conscious or have dietary restrictions, look for labels that specify the product is non-GMO, gluten-free, soy-free (if applicable), and free from other common allergens.
6. Manufacturing Standards: Ensure the product is manufactured in a facility that follows Good Manufacturing Practices (GMP). This adherence to GMP indicates that the product is produced under strict quality control standards.
7. Origin and Source: Information about the source of Nattokinase can also be important. Ideally, the label should mention that the Nattokinase is derived from the traditional fermentation of soybeans using Bacillus subtilis.
8. Expiration Date and Storage Information: Make sure the supplement has a clear expiration date, and follow any storage instructions to maintain its efficacy. This ensures you are using the product while it is still effective.
9. Dosage Instructions: Clear dosage instructions can help you understand how to take the supplement for optimal benefits, including the recommended number of capsules per day and whether to take them with food or on an empty stomach.

In summary, to ensure the quality of a Nattokinase supplement, look for standardization and potency information, enteric coating, purity with minimal additives, third-party testing, non-GMO and allergen-free certifications, adherence to manufacturing standards, clear origin and source details, an expiration date, and clear dosage instructions. These factors collectively contribute to the effectiveness and safety of the supplement.

The information provided on this website, including any text, images, or other material contained within, is for informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. This page was created by the SuppCo editiorial team, with AI summarization tools, including data from but not limited to following studies: