Iodine is an essential trace mineral that plays a crucial role in the proper functioning of the thyroid gland. It is a vital component of thyroid hormones, such as thyroxine (T4) and triiodothyronine (T3), which regulate various metabolic processes in the body, including growth, development, and energy expenditure. These hormones are pivotal in ensuring that the body's cells function optimally, influencing everything from heart rate to body temperature and even cognitive function.

In terms of dietary sources, iodine is most commonly found in iodized table salt, fish, dairy products, and eggs. However, the richest natural source of iodine is seaweed. Despite its presence in various foods, iodine deficiency can still occur, particularly in regions where the soil is iodine-poor or in populations that do not consume seafood. Iodine deficiency is of particular concern for pregnant women, as it can affect fetal development and lead to complications.

The discovery of iodine dates back to the early 19th century, and its importance in thyroid function was recognized soon after. Historically, iodine deficiency was a significant public health issue, leading to the development of iodized salt programs to combat goiter and other thyroid-related disorders. Today, while iodine deficiency is less common in developed countries, it remains a significant concern in certain parts of the world.

Iodine is primarily used to ensure proper thyroid function. The thyroid gland relies on iodine to synthesize the thyroid hormones thyroxine (T4) and triiodothyronine (T3), which regulate metabolism, growth, and development throughout the body. Adequate iodine intake is crucial for preventing disorders such as goiter, which is an enlargement of the thyroid gland due to iodine deficiency. In pregnant women, sufficient iodine levels are essential to support fetal brain development and to prevent neurodevelopmental deficits.

Several studies have highlighted the importance of iodine in maintaining thyroid health. For instance, research published in "The Journal of Clinical Endocrinology & Metabolism" demonstrated that iodine supplementation in iodine-deficient subjects increased serum T4 concentrations and decreased T3 concentrations, thereby normalizing thyroid hormone levels (Stevenson et al., 1974). Another study in the "Journal of Nuclear Medicine" examined the effects of iodide supplementation in patients with autoimmune thyroiditis, finding that iodine could improve serum thyroid hormone levels in some patients while potentially aggravating thyroid disorders in others (Fragu et al., 1985).

Iodine's role extends beyond thyroid health. In regions with iodine deficiency, supplementation has been shown to enhance cognitive function in children. A study published in "The American Journal of Clinical Nutrition" reported that iodine supplementation improved cognitive and motor performance in iodine-deficient schoolchildren in Albania (Zimmermann et al., 2006). However, it is important to note that while iodine supplementation can offer benefits, excessive iodine intake may lead to adverse effects, such as thyroid dysfunction. Therefore, maintaining an appropriate balance is key.

In summary, iodine is used predominantly for thyroid hormone production, which is crucial for metabolic regulation and overall health. Studies consistently support the need for adequate iodine intake to prevent deficiency-related disorders and highlight its broader benefits in cognitive development, particularly in children from iodine-deficient areas.

Iodine operates at the core of thyroid hormone synthesis. The thyroid gland absorbs iodine from the bloodstream and incorporates it into the amino acid tyrosine to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). These hormones are then released into the bloodstream, where they play a pivotal role in regulating metabolism, growth, and development. The process of iodine uptake and hormone synthesis is tightly controlled by the hypothalamic-pituitary-thyroid axis, a feedback loop that ensures hormone levels remain within the optimal range.

Once ingested, iodine is absorbed in the stomach and small intestine, entering the bloodstream. The thyroid gland, equipped with the sodium-iodide symporter (NIS), actively transports iodine from the blood into thyroid cells. Inside the thyroid cells, iodine undergoes a series of enzymatic reactions, catalyzed by thyroid peroxidase, to form iodinated tyrosines. These iodinated tyrosines are then coupled to form T3 and T4, which are stored in the thyroid gland until needed.

The release of T3 and T4 into the bloodstream is regulated by thyroid-stimulating hormone (TSH), which is secreted by the pituitary gland in response to signals from the hypothalamus. When blood levels of T3 and T4 drop, the hypothalamus releases thyrotropin-releasing hormone (TRH), which stimulates the pituitary gland to produce TSH. TSH then prompts the thyroid gland to release stored T3 and T4, restoring hormone levels to their normal range.

In peripheral tissues, T4 is often converted to the more active T3 by deiodinase enzymes. T3 then binds to thyroid hormone receptors in the nucleus of cells, influencing the expression of genes involved in energy production, protein synthesis, and other metabolic processes. This mechanism underscores the broad influence of iodine on various bodily functions, from basal metabolic rate to cognitive development and overall growth.

In summary, iodine is integral to the synthesis and regulation of thyroid hormones. It is absorbed from the diet, processed by the thyroid gland, and transformed into hormones that regulate a wide array of physiological processes. The body's ability to maintain a delicate balance of iodine is crucial for optimal health and metabolic function.

Iodine plays a critical role in both men's and women's health, but its importance is particularly pronounced in women due to the unique demands placed on the thyroid gland during pregnancy and lactation. While both men and women require iodine for the synthesis of thyroid hormones, which regulate metabolism, energy production, and overall physiological function, women have additional needs that make adequate iodine intake even more crucial.

During pregnancy, a woman's iodine requirements increase significantly. This is because iodine is essential for the development of the fetal brain and nervous system. Adequate iodine levels help ensure proper thyroid function in both the mother and the developing fetus. An iodine deficiency during pregnancy can lead to complications such as cretinism, a condition characterized by severe mental and physical developmental delays in the child. Studies, like those published in "The Journal of Clinical Endocrinology & Metabolism," have shown that iodine supplementation during pregnancy can help maintain normal thyroid function and reduce the risk of developmental issues in the child (Pedersen et al., 1993).

Lactating women also have increased iodine needs, as iodine is transferred to the infant through breast milk. This transfer ensures that the infant receives sufficient iodine for continued growth and brain development during the early stages of life. Inadequate iodine intake in lactating women can lead to iodine deficiency in infants, potentially affecting their cognitive development.

In men, while the overall iodine requirements are generally the same as in women, the focus is more on maintaining optimal thyroid function to support metabolic processes, energy levels, and overall health. Iodine deficiency in men can lead to conditions such as hypothyroidism, which is characterized by fatigue, weight gain, and cognitive difficulties. Ensuring adequate iodine intake can help prevent these issues and support overall well-being.

In summary, while iodine is essential for both men and women, its role is particularly critical for women during pregnancy and lactation due to the increased demands on thyroid function and the need to support fetal and infant development. Ensuring adequate iodine intake in women during these life stages is crucial for preventing developmental issues in children and maintaining maternal health. Studies consistently highlight the importance of iodine supplementation in these contexts to support optimal health outcomes.

The recommended daily intake of iodine varies based on age, sex, and life stage. For most adults, the recommended dietary allowance (RDA) is 150 micrograms per day. However, certain groups, such as pregnant and lactating women, have higher iodine requirements to support fetal and infant development. Pregnant women are advised to consume 220 micrograms per day, while lactating women should aim for 290 micrograms per day. These recommendations ensure that both the mother and the developing child receive adequate iodine to support optimal thyroid function and development.

For children, the RDA of iodine is adjusted according to age. Infants (0-6 months) require about 110 micrograms per day, while those aged 7-12 months need 130 micrograms per day. As children grow, their iodine requirements increase: 90 micrograms per day for ages 1-8, and 120 micrograms per day for ages 9-13. Adolescents (14-18 years) should aim for 150 micrograms per day, similar to adults, to support their rapid growth and development.

It's important to note that while iodine is essential, excessive intake can lead to thyroid dysfunction. The upper intake level (UL) for iodine, which represents the maximum daily intake unlikely to cause adverse health effects, is set at 1,100 micrograms per day for adults. Exceeding this limit can lead to conditions such as iodine-induced hyperthyroidism or hypothyroidism, particularly in individuals with pre-existing thyroid disorders.

The best way to ensure adequate iodine intake is through a balanced diet that includes iodine-rich foods such as iodized salt, dairy products, fish, and seaweed. In regions where iodine deficiency is prevalent, iodized salt programs have been highly effective in improving iodine status across populations. For individuals who may not get enough iodine from their diet, such as those on restricted diets or living in iodine-deficient areas, iodine supplements can be beneficial. However, it is important to follow recommended dosages to avoid excessive intake.

In summary, the recommended daily intake of iodine varies by age and life stage, with higher requirements for pregnant and lactating women. While dietary sources can generally meet these needs, supplements may be necessary for certain individuals. It is crucial to adhere to recommended guidelines to avoid the risks associated with both iodine deficiency and excess.

While iodine is essential for thyroid function and overall health, excessive intake or improper use can lead to several side effects. One of the primary concerns with high iodine intake is its impact on thyroid function. Both iodine deficiency and excess can disrupt the delicate balance of thyroid hormone production, potentially leading to conditions such as hypothyroidism or hyperthyroidism.

Hypothyroidism, characterized by an underactive thyroid gland, can occur when excessive iodine intake inhibits thyroid hormone production. Symptoms of hypothyroidism may include fatigue, weight gain, cold intolerance, and depression. A study published in the "Journal of the Endocrine Society" found that high dietary iodide intake can induce hypothyroidism in certain mouse strains without underlying thyroid disorders, suggesting that similar effects might occur in humans (McLachlan et al., 2017).

On the flip side, hyperthyroidism, characterized by an overactive thyroid gland, can also result from excessive iodine intake, particularly in individuals with pre-existing thyroid nodules or latent Graves' disease. Symptoms of hyperthyroidism may include weight loss, rapid heartbeat, anxiety, and tremors. Chronic intake of iodine at levels significantly higher than the recommended daily allowance can precipitate this condition, as noted in studies examining the effects of iodine supplementation in different populations.

Another potential side effect of excessive iodine intake is the development of iodine-induced goiter, an enlargement of the thyroid gland. This condition can occur when high iodine levels interfere with the gland's ability to produce thyroid hormones, leading to compensatory growth. Additionally, individuals with autoimmune thyroid conditions, such as Hashimoto's thyroiditis, may experience aggravated symptoms with increased iodine intake, as highlighted in research published in the "Journal of Nuclear Medicine" (Fragu et al., 1985).

It's also worth noting that some individuals may experience gastrointestinal discomfort, such as nausea or stomach upset, when taking high doses of iodine supplements. While these side effects are generally mild and transient, they can be bothersome and may necessitate adjustments in dosage or form of supplementation.

In summary, while iodine is essential for health, excessive intake can lead to various side effects, particularly affecting thyroid function. Hypothyroidism, hyperthyroidism, and goiter are potential risks associated with high iodine levels. Individuals with pre-existing thyroid conditions should be particularly cautious with iodine supplementation. As with any supplement, it is crucial to adhere to recommended dosages and consult with a healthcare provider if adverse effects are experienced.

While iodine is essential for overall health and thyroid function, certain individuals should exercise caution or avoid taking iodine supplements. Those with specific health conditions or sensitivities may be at risk of adverse effects from supplemental iodine, making it crucial to consider individual health circumstances.

Firstly, individuals with known iodine sensitivity or allergy should avoid iodine supplements. Although rare, iodine allergies can result in reactions ranging from mild skin rashes to severe anaphylactic responses. These individuals should seek alternative ways to ensure adequate iodine intake, ideally under the guidance of a healthcare provider.

People with certain thyroid disorders, such as hyperthyroidism or autoimmune thyroid diseases like Hashimoto's thyroiditis, should be cautious with iodine supplementation. Excessive iodine intake can exacerbate these conditions. For instance, in individuals with Graves' disease, a condition characterized by an overactive thyroid, additional iodine can further stimulate thyroid hormone production and worsen symptoms. Similarly, those with Hashimoto's thyroiditis may experience increased inflammation and thyroid dysfunction with high iodine intake, as research in the "Journal of Nuclear Medicine" suggests (Fragu et al., 1985).

Patients undergoing treatment for thyroid cancer, particularly those receiving radioactive iodine therapy, should avoid non-prescribed iodine supplements. Excess iodine intake can interfere with the effectiveness of radioactive iodine treatment, which relies on the thyroid gland's uptake of radioactive isotopes to target cancerous cells.

Individuals with a history of thyroid nodules should also be cautious with iodine supplementation. High iodine intake can sometimes lead to the development of iodine-induced hyperthyroidism in individuals with pre-existing thyroid nodules. Monitoring iodine intake and thyroid function is critical in these cases to avoid exacerbating thyroid imbalances.

Lastly, while pregnant and lactating women have increased iodine requirements, they should still consult their healthcare provider before starting iodine supplements. This ensures that they receive the appropriate dosage without exceeding safe intake levels, thereby avoiding potential risks to both mother and child.

In summary, while iodine is vital for health, certain individuals should avoid or carefully manage iodine supplementation. These include those with iodine sensitivity, certain thyroid disorders, thyroid cancer patients undergoing specific treatments, individuals with thyroid nodules, and pregnant or lactating women. Consulting with a healthcare provider can help determine the best approach to ensuring adequate iodine intake without adverse effects.

Yes, iodine supplements can interact with certain medications, potentially affecting their efficacy or leading to adverse effects. It's crucial to be aware of these interactions and consult with a healthcare provider before starting iodine supplementation, especially if you are taking any prescription medications.

One of the primary interactions involves thyroid medications. For individuals being treated for hypothyroidism, such as those taking levothyroxine, iodine supplements can alter thyroid hormone levels and potentially necessitate adjustments in medication dosage. Excessive iodine can either inhibit or overstimulate thyroid hormone production, complicating the management of thyroid conditions.

Another important interaction is with antithyroid medications, such as methimazole or propylthiouracil, which are used to treat hyperthyroidism. These medications work by reducing thyroid hormone production, and additional iodine intake can interfere with their effectiveness. For example, in patients with Graves' disease, excessive iodine can counteract the effects of antithyroid drugs, making it harder to control hyperthyroid symptoms.

Iodine can also interact with certain cardiovascular medications. For instance, amiodarone, a medication used to treat irregular heart rhythms, contains a high amount of iodine and can significantly affect thyroid function. Supplementing with additional iodine while on amiodarone can exacerbate thyroid-related side effects, such as hypothyroidism or hyperthyroidism. Studies published in "Annals of Internal Medicine" highlight the complex relationship between amiodarone and iodine, emphasizing the need for careful monitoring of thyroid function in patients taking this medication (Martino et al., 1984).

Furthermore, iodine supplements can interact with lithium, a medication commonly used to treat bipolar disorder. Lithium can affect thyroid function, often leading to hypothyroidism. Adding iodine supplements can further complicate thyroid regulation in individuals taking lithium, potentially requiring careful monitoring and adjustment of both iodine intake and medication dosage.

Lastly, iodine supplements may interact with potassium-sparing diuretics, such as spironolactone. High doses of iodine can lead to elevated potassium levels in the blood, increasing the risk of hyperkalemia, a condition characterized by dangerously high potassium levels that can affect heart function.

In summary, iodine supplements can interact with several medications, including thyroid medications, antithyroid drugs, cardiovascular medications like amiodarone, lithium, and potassium-sparing diuretics. These interactions underscore the importance of consulting with a healthcare provider before starting iodine supplementation, especially if you are on any of these medications, to ensure safe and effective management of your health.

The best sources of iodine are primarily found in certain foods and iodized salt. Ensuring a diet that includes these sources can help maintain adequate iodine levels, which is essential for thyroid health and overall well-being.

One of the richest natural sources of iodine is seaweed. Varieties such as kelp, nori, and wakame are particularly high in iodine. For example, a small serving of kelp can provide significantly more than the daily recommended intake of iodine. However, it's important to consume seaweed in moderation due to the potential for excessive iodine intake.

Fish and seafood are also excellent sources of iodine. Fish like cod, haddock, and tuna, as well as shellfish such as shrimp and oysters, contain substantial amounts of iodine. Incorporating these into your diet a few times a week can help ensure you get enough iodine.

Dairy products, including milk, cheese, and yogurt, are good sources of iodine as well. Iodine content in dairy products can vary based on the iodine content of the animal feed, but generally, these products contribute significantly to dietary iodine intake. For instance, a cup of milk can provide around 50-80 micrograms of iodine, which is about one-third to one-half of the daily recommended intake for adults.

Eggs are another valuable source of iodine. The iodine is primarily concentrated in the yolk. Including eggs in your diet can provide a consistent source of this essential mineral.

Iodized salt is one of the most common and reliable sources of iodine. The introduction of iodized salt has significantly reduced the prevalence of iodine deficiency in many parts of the world. A small amount of iodized salt can meet the daily iodine requirements, making it an easy way to ensure adequate intake. However, it is essential to balance salt intake to avoid excessive sodium consumption.

Some plant-based foods, such as certain grains and fruits, can also provide iodine, though typically in smaller amounts. The iodine content in these foods can vary depending on the iodine content of the soil where they are grown.

In summary, the best sources of iodine include seaweed, fish and seafood, dairy products, eggs, and iodized salt. Incorporating a variety of these foods into your diet can help maintain adequate iodine levels and support thyroid health. For individuals with specific dietary restrictions or those living in iodine-deficient areas, iodine supplements may be necessary, but it's important to consult with a healthcare provider to ensure appropriate intake.

Iodine is available in several forms, each suited to different applications and preferences. Understanding the various forms can help you choose the best option for your specific needs, whether it's for dietary supplementation, medical use, or nutritional fortification.

1. Iodized Salt: One of the most common forms of iodine is iodized salt. Table salt fortified with iodine is a primary source of this essential mineral in many diets worldwide. The addition of potassium iodide or potassium iodate to table salt has been a public health strategy to combat iodine deficiency. This is an easy and inexpensive way to ensure adequate iodine intake, especially in areas where natural iodine sources are limited.

2. Iodine Supplements: Iodine supplements come in various forms, including tablets, capsules, and liquid drops. These supplements typically contain potassium iodide or sodium iodide as the active ingredient. They are especially useful for individuals who have higher iodine needs, such as pregnant and lactating women, or those who do not consume sufficient iodine through their diet. Supplements can provide a controlled and consistent dose of iodine, making them an effective way to address deficiency.

3. Dietary Sources: While not a "form" in the traditional sense, consuming iodine-rich foods is a natural way to ensure adequate iodine intake. As mentioned earlier, seaweed, fish, dairy products, eggs, and iodized salt are excellent sources. These foods supply iodine in its naturally occurring forms, such as iodide and iodate, which are readily absorbed and utilized by the body.

4. Topical Iodine: Iodine solutions, such as povidone-iodine, are widely used for their antiseptic properties. These are typically applied to the skin to prevent infection in minor cuts, wounds, and surgical sites. While not intended for dietary supplementation, topical iodine plays a crucial role in medical and first-aid settings.

5. Lugol's Iodine: This is a specific formulation of iodine that contains iodine and potassium iodide in water. Lugol's iodine is often used in medical settings for diagnostic purposes, such as thyroid function tests, and can also be used as a dietary supplement. It is available in various concentrations, so it's important to use it under medical supervision to avoid excessive intake.

6. Iodine-Containing Medications: Certain medications contain iodine as part of their formulation. For example, amiodarone, a medication used to treat cardiac arrhythmias, contains a high amount of iodine. These medications are prescribed for specific medical conditions and are not used for general iodine supplementation.

7. Fortified Foods: In some regions, foods other than salt are fortified with iodine to help address dietary deficiencies. Examples include iodine-fortified bread, milk, and other dairy products. These fortified foods provide an additional dietary source of iodine, especially in populations at risk of deficiency.

In summary, iodine is available in various forms, including iodized salt, dietary supplements, topical solutions, Lugol's iodine, iodine-containing medications, and fortified foods. Each form has its specific uses and benefits, making it important to choose the appropriate form based on individual needs and circumstances.

Iodine's efficacy, particularly in dietary and medical contexts, often hinges on its sub-compounds, which play distinct roles in its absorption, utilization, and overall impact on health. The primary sub-compounds of iodine include iodide (I⁻), iodate (IO₃⁻), and molecular iodine (I₂). Each of these has unique properties and applications that contribute to the effectiveness of iodine in various forms.

1. Iodide (I⁻): Iodide is the most common form of iodine used in dietary supplements and iodized salt. Potassium iodide and sodium iodide are the typical compounds added to table salt and used in supplements. Iodide is readily absorbed by the body and efficiently utilized by the thyroid gland to produce thyroid hormones. Its bioavailability and ease of incorporation into everyday foods make it a critical sub-compound for preventing iodine deficiency and maintaining thyroid health. Studies have shown that iodide supplementation effectively increases serum iodine levels and normalizes thyroid function (Stevenson et al., 1974).

2. Iodate (IO₃⁻): Iodate is another form of iodine commonly used in the fortification of salt. While iodate is less soluble than iodide, it is equally effective in preventing iodine deficiency when added to salt. The body can convert iodate to iodide, making it bioavailable for thyroid hormone synthesis. Potassium iodate is often preferred in regions with hot and humid climates because it is more stable in such conditions compared to iodide. Research indicates that iodate-fortified salt is an effective means of improving iodine nutrition in populations (Pedersen et al., 1993).

3. Molecular Iodine (I₂): Molecular iodine is used less frequently in dietary contexts but has significant applications in medical and antiseptic settings. I₂ is the active component in solutions like Lugol's iodine and povidone-iodine, which are used for disinfection and antiseptic purposes. In these forms, molecular iodine exhibits strong antimicrobial properties, making it valuable for preventing infections in medical and surgical environments. Although not commonly ingested, molecular iodine can be used in specific diagnostic tests related to thyroid function.

4. Organic Iodine Compounds: Certain medications and diagnostic agents contain organic iodine compounds. For example, amiodarone, used to treat cardiac arrhythmias, contains a high amount of iodine in an organic form. These compounds release iodine in the body, influencing thyroid function and providing therapeutic effects. Organic iodine compounds are critical in various medical treatments and diagnostic procedures, demonstrating the versatility of iodine in different chemical forms.

5. Thyroid Hormones (T3 and T4): While not sub-compounds of iodine per se, the thyroid hormones triiodothyronine (T3) and thyroxine (T4) are direct products of iodine utilization in the body. These hormones are synthesized from iodide in the thyroid gland and are essential for regulating metabolism, growth, and development. The conversion of iodide to these active hormones underscores the importance of iodine's bioavailability and its integration into physiological processes.

In summary, the sub-compounds of iodine, including iodide, iodate, and molecular iodine, are critical to its efficacy in both dietary and medical contexts. Iodide and iodate are primarily used for dietary supplementation and fortification, ensuring bioavailability and stability. Molecular iodine is vital for its antiseptic properties in medical applications. Understanding these sub-compounds helps optimize iodine's use in preventing deficiency and supporting overall health.

Iodine, a vital mineral for thyroid function and overall health, is known by several names and can be found in various forms. Understanding these different names and forms can help in identifying iodine in dietary supplements, medications, and food products.

Common Names and Chemical Forms:

1. Iodine (I₂): The elemental form of iodine, often used in medical and antiseptic applications.
2. Iodide (I⁻): A common form of iodine found in supplements and iodized salt. It is often listed as potassium iodide (KI) or sodium iodide (NaI).
3. Iodate (IO₃⁻): Another form of iodine used in salt fortification, typically listed as potassium iodate (KIO₃).
4. Lugol's Iodine: A solution of molecular iodine (I₂) and potassium iodide (KI) in water, used for medical and diagnostic purposes.
5. Povidone-Iodine: A complex of iodine with povidone, used as a topical antiseptic.

Abbreviations:

1. I: The chemical symbol for elemental iodine.
2. KI: The abbreviation for potassium iodide, a common form of dietary iodine.
3. NaI: The abbreviation for sodium iodide, another form used in supplements and medical imaging.

Common Misspellings:

1. Iodene
2. Iodide (though technically correct, it is sometimes mistakenly used when referring to elemental iodine)
3. Iodin
4. Iodein

Alternative Names and Ingredients:

1. Elemental Iodine: Sometimes referred to simply as "iodine" in its pure form.
2. Thyroid Hormones (T3 and T4): While not iodine itself, these hormones are synthesized from iodine and are sometimes mentioned in discussions about iodine's role in health.
3. Seaweed Extract: Often listed on supplement labels, seaweed is a rich natural source of iodine.
4. Iodized Salt: Table salt fortified with iodine, typically in the form of potassium iodide or potassium iodate.
5. Kelp: A type of seaweed high in iodine, commonly found in dietary supplements.
6. Iodophor: A combination of iodine with a solubilizing agent or carrier that releases free iodine in solution, used as a disinfectant.

In summary, iodine is known by various names and forms, including elemental iodine (I₂), iodide (I⁻), iodate (IO₃⁻), and in solutions like Lugol's iodine and povidone-iodine. It is also found in food products and supplements as iodized salt, kelp, and seaweed extract. Recognizing these names and forms can help in identifying iodine in different contexts and ensuring adequate intake for health.

When selecting an iodine supplement, it's essential to scrutinize the label to ensure you are choosing a high-quality product that is safe and effective. Here are several key factors to consider:

1. Form of Iodine: Check the type of iodine used in the supplement. The most common forms are potassium iodide (KI) and sodium iodide (NaI). Both are well-absorbed and effective for preventing iodine deficiency. Some supplements may also use kelp or other seaweed extracts, which are natural sources of iodine. Ensure that the form of iodine is clearly stated on the label.

2. Dosage: Verify the amount of iodine per serving. The label should indicate the iodine content in micrograms (µg). The recommended daily allowance (RDA) for iodine varies by age and life stage, but for most adults, it is 150 µg per day. Pregnant and lactating women require higher amounts, typically 220 µg and 290 µg per day, respectively. Ensure the dosage aligns with your specific needs without exceeding the upper limit of 1,100 µg per day to avoid potential toxicity.

3. Third-Party Testing and Certification: Look for supplements that have been third-party tested for purity, potency, and quality. Certifications from organizations such as the United States Pharmacopeia (USP), NSF International, or ConsumerLab.com indicate that the product has undergone rigorous testing to verify its contents and quality. These certifications provide an added layer of assurance that the supplement meets high standards.

4. Ingredient List: Examine the ingredient list for any additional components. A high-quality iodine supplement should ideally contain minimal additives, fillers, or artificial ingredients. If the supplement includes other vitamins or minerals, ensure they are present in appropriate amounts and do not exceed recommended daily values.

5. Expiration Date: Check the expiration date to ensure the product is fresh and effective. Using supplements past their expiration date can result in reduced potency and effectiveness.

6. Brand Reputation: Choose supplements from reputable brands that have a history of producing high-quality products. Research the brand's reputation, read customer reviews, and check for any recalls or safety concerns associated with their products.

7. Allergen Information: If you have allergies or dietary restrictions, verify that the supplement is free from common allergens such as gluten, dairy, soy, and nuts. The label should clearly state if the product is hypoallergenic or suitable for specific dietary needs, such as vegan or vegetarian.

8. Usage Instructions: Ensure the label provides clear usage instructions, including the recommended dosage, frequency, and any specific instructions for optimal absorption. For example, some iodine supplements may be best taken with food to enhance absorption.

In summary, when choosing an iodine supplement, look for the type of iodine used, appropriate dosage, third-party testing and certification, minimal additives, a valid expiration date, a reputable brand, allergen information, and clear usage instructions. By carefully reviewing the label, you can select a high-quality iodine supplement that meets your health needs safely and effectively.

The information provided on this website, including any text, images, or other material contained within, is for informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. This page was created by the SuppCo editiorial team, with AI summarization tools, including data from but not limited to following studies:

1. Carlos Stevenson, Enrique Silva, Gustavo Pineda (1974). Thyroxine (T4) and triiodothyronine (T3): effects of iodine on the serum concentrations and disposal rates in subjects from an endemic goiter area.. The Journal of clinical endocrinology and metabolism, 38 3,
   390-3 . Link: 10.1210/JCEM-38-3-390
2. P. Fragu, M. Schlumberger, M. Tubiana (1985). Thyroid iodine content and serum thyroid hormone levels in autoimmune thyroiditis: effect of iodide supplementation.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 26 2,
   133-9 . Link:
3. P. Heidemann, P. Stubbe (1978). Serum 3,5,3'-triiodothyronine, thyroxine, and thyrotropin in hypothyroid infants with congenital goiter and the response to iodine.. The Journal of clinical endocrinology and metabolism, 47 1,
   189-92 . Link: 10.1210/JCEM-47-1-189
4. K. Okamura, A. Taurog, L. Krulich (1981). Elevation of serum 3,5,3'-triiodothyronine and thyroxine levels in rats fed Remington diets; opposing effects of nutritional deficiency and iodine deficiency.. Endocrinology, 108 4,
   1247-56 . Link: 10.1210/ENDO-108-4-1247
5. S. Parveen, S. Latif, M. Kamal, M. Uddin (2007). Effects of long term iodized table salt consumption on serum T3, T4 and TSH in an iodine deficient area of Bangladesh.. Mymensingh medical journal : MMJ, 16 1,
   57-60 . Link: 10.3329/MMJ.V16I1.249
6. T. Paul, Bruce Meyers, R. Witorsch, S. Pino, S. Chipkin, S. Ingbar, L. Braverman (1988). The effect of small increases in dietary iodine on thyroid function in euthyroid subjects.. Metabolism: clinical and experimental, 37 2,
   121-4 . Link: 10.1016/S0026-0495(98)90004-X
7. S. Ares, H. Escobar-Morreale, José Quero, Socorro Duran, Maria Jesus Presas, Rafael Herruzo, G. Morreale de Escobar (1997). Neonatal hypothyroxinemia: effects of iodine intake and premature birth.. The Journal of clinical endocrinology and metabolism, 82 6,
   1704-12 . Link: 10.1210/JCEM.82.6.4019
8. I. Chopra, J. Sack, D. Fisher (1975). 3,3',5'-Triiodothyronine (reverse T3) and 3,3',5-triiodothyronine (T3) in fetal and adult sheep: studies of metabolic clearance rates, production rates, serum binding, and thyroidal content relative to thyroxine.. Endocrinology, 97 5,
   1080-8 . Link: 10.1210/ENDO-97-5-1080
9. A. Burger, D. Dinichert, P. Nicod, M. Jenny, T. Lemarchand-Béraud, M. Vallotton (1976). Effect of amiodarone on serum triiodothyronine, reverse triiodothyronine, thyroxin, and thyrotropin. A drug influencing peripheral metabolism of thyroid hormones.. The Journal of clinical investigation, 58 2,
   255-9 . Link: 10.1172/JCI108466
10. E. Martino, M. Safran, F. Aghini‐Lombardi, R. Rajatanavin, M. Lenziardi, Madeleine Fay, A. Pacchiarotti, N. Aronin, E. Macchia, C. Haffajee, L. Odoguardi, J. Love, Aldo Bigalli, L. Baschieri, A. Pinchera, L. Braverman (1984). Environmental iodine intake and thyroid dysfunction during chronic amiodarone therapy.. Annals of internal medicine, 101 1,
    28-34 . Link: 10.7326/0003-4819-101-1-28
11. S. McLachlan, H. Aliesky, B. Rapoport (2017). Aberrant Iodine Autoregulation Induces Hypothyroidism in a Mouse Strain in the Absence of Thyroid Autoimmunity. Journal of the Endocrine Society, 2, 63 - 76. Link: 10.1210/js.2017-00400
12. Garcilaso Riesco, Alvin Taurog, P. Larsen, Ladislav Krulich (1977). Acute and chronic responses to iodine deficiency in rats.. Endocrinology, 100 2,
    303-13 . Link: 10.1210/ENDO-100-2-303
13. Carlos Stevenson, Enrique Silva, Gustavo Pineda (1974). Thyroxine (T4) and triiodothyronine (T3): effects of iodine on the serum concentrations and disposal rates in subjects from an endemic goiter area.. The Journal of clinical endocrinology and metabolism, 38 3,
    390-3 . Link: 10.1210/JCEM-38-3-390
14. S. Ares, H. Escobar-Morreale, José Quero, Socorro Duran, Maria Jesus Presas, Rafael Herruzo, G. Morreale de Escobar (1997). Neonatal hypothyroxinemia: effects of iodine intake and premature birth.. The Journal of clinical endocrinology and metabolism, 82 6,
    1704-12 . Link: 10.1210/JCEM.82.6.4019
15. P. Fragu, M. Schlumberger, M. Tubiana (1985). Thyroid iodine content and serum thyroid hormone levels in autoimmune thyroiditis: effect of iodide supplementation.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 26 2,
    133-9 . Link:
16. K. M. Pedersen, P. Laurberg, E. Iversen, P. R. Knudsen, H. Gregersen, O. S. Rasmussen, K. R. Larsen, G. M. Eriksen, P. L. Johannesen (1993). Amelioration of some pregnancy-associated variations in thyroid function by iodine supplementation.. The Journal of clinical endocrinology and metabolism, 77 4,
    1078-83 . Link: 10.1210/JCEM.77.4.8408456
17. M. Suh, L. Abraham, J. Hixon, D. Proctor (2014). The effects of perchlorate, nitrate, and thiocyanate on free thyroxine for potentially sensitive subpopulations of the 2001–2002 and 2007–2008 National Health and Nutrition Examination Surveys. Journal of Exposure Science and Environmental Epidemiology, 24, 579-587. Link: 10.1038/jes.2013.67
18. K. Okamura, A. Taurog, L. Krulich (1981). Elevation of serum 3,5,3'-triiodothyronine and thyroxine levels in rats fed Remington diets; opposing effects of nutritional deficiency and iodine deficiency.. Endocrinology, 108 4,
    1247-56 . Link: 10.1210/ENDO-108-4-1247
19. M. Many, J. Denef, S. Hamudi, C. Cornette, S. Haumont, C. Beckers (1986). Effects of iodide and thyroxine on iodine-deficient mouse thyroid: a morphological and functional study.. The Journal of endocrinology, 110 2,
    203-10 . Link: 10.1677/JOE.0.1100203
20. P. Larsen, J. E. Silva, M. Kaplan (1981). Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications.. Endocrine reviews, 2 1,
    87-102 . Link: 10.1210/EDRV-2-1-87
21. Ying Sun, Xin Du, Z. Shan, W. Teng, Yaqiu Jiang (2021). Effects of iodine excess on serum thyrotropin-releasing hormone levels and type 2 deiodinase in the hypothalamus of Wistar rats. British Journal of Nutrition, 127, 1631 - 1638. Link: 10.1017/S0007114521002592
22. Sofia Manousou, R. Eggertsen, L. Hulthén, H. Filipsson Nyström (2021). A randomized, double-blind study of iodine supplementation during pregnancy in Sweden: pilot evaluation of maternal iodine status and thyroid function. European Journal of Nutrition, 60, 3411 - 3422. Link: 10.1007/s00394-021-02515-1
23. F. Soriguer, C. Gutiérrez‐Repiso, E. Rubio‐Martín, F. Linares, Isabel Cardona, Jaime López-Ojeda, Marta Pacheco, S. González-Romero, M. J. Garriga, Inés Velasco, Piedad Santiago, E. García‐Fuentes (2011). Iodine intakes of 100–300 μg/d do not modify thyroid function and have modest anti-inflammatory effects. British Journal of Nutrition, 105, 1783 - 1790. Link: 10.1017/S0007114510005568
24. M. Zimmermann, K. Connolly, M. Bozo, J. Bridson, F. Rohner, L. Grimci (2006). Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study.. The American journal of clinical nutrition, 83 1,
    108-14 . Link: 10.1093/AJCN/83.1.108
25. K. Harding, J. P. Peña-Rosas, A. Webster, Constance MY Yap, B. Payne, E. Ota, L. De-Regil (2017). Iodine supplementation for women during the preconception, pregnancy and postpartum period.. The Cochrane database of systematic reviews, 3,
    CD011761 . Link: 10.1002/14651858.CD011761.pub2
26. M. Dineva, Harry Fishpool, M. Rayman, J. Mendis, S. Bath (2020). Systematic review and meta-analysis of the effects of iodine supplementation on thyroid function and child neurodevelopment in mildly-to-moderately iodine-deficient pregnant women.. The American journal of clinical nutrition, , . Link: 10.1093/ajcn/nqaa071
27. S. O’Kane, M. Mulhern, L. Pourshahidi, J. Strain, A. Yeates (2018). Micronutrients, iodine status and concentrations of thyroid hormones: a systematic review. Nutrition Reviews, 76, 418–431. Link: 10.1093/nutrit/nuy008
28. M. Zimmermann, K. Boelaert (2015). Iodine deficiency and thyroid disorders.. The lancet. Diabetes & endocrinology, 3 4,
    286-95 . Link: 10.1016/S2213-8587(14)70225-6
29. J. Farebrother, M. Zimmermann, M. Andersson (2019). Excess iodine intake: sources, assessment, and effects on thyroid function. Annals of the New York Academy of Sciences, 1446, . Link: 10.1111/nyas.14041
30. P. Moseki, D. Graham, I. Salt, E. Combet (2023). PS-B04-3: SHORT-TERM LOW IODINE DIET EXACERBATES VASCULAR REACTIVITY WITHOUT ALTERING THYROID HORMONE PROFILES IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS. Journal of Hypertension, 41, e360. Link: 10.1097/01.hjh.0000916444.04285.9d