Gotu Kola, scientifically known as *Centella asiatica*, is a perennial plant that belongs to the Apiaceae family. Native to the wetlands of Asia, this herb is commonly found in countries such as India, Sri Lanka, China, and Indonesia.
About Gotu Kola
- What is Gotu Kola?
- What is Gotu Kola used for, and what do the studies say?
- How does Gotu Kola work?
- How is Gotu Kola used differently in men’s and women’s health?
- How much Gotu Kola should I take?
- What are the main side effects of Gotu Kola?
- Who should not take Gotu Kola?
- Are Gotu Kola supplements known to interact with any medications?
- What are the best sources of Gotu Kola?
- What forms does Gotu Kola come in?
- Which sub-compounds of Gotu Kola, if any, are critical to the efficacy of Gotu Kola?
- What is Gotu Kola also known as?
- What is important to look for on the label of a Gotu Kola supplement to ensure product quality?
- Disclaimer & References
What is Gotu Kola?
Gotu Kola, scientifically known as Centella asiatica, is a perennial plant that belongs to the Apiaceae family. Native to the wetlands of Asia, this herb is commonly found in countries such as India, Sri Lanka, China, and Indonesia. Unlike many other herbs, Gotu Kola is consumed both as a medicinal plant and a culinary ingredient, often incorporated into salads, smoothies, and herbal teas.
The plant is characterized by its small, fan-shaped green leaves and delicate white or light purple flowers. It thrives in tropical and subtropical climates and prefers moist, swampy areas. Traditionally, Gotu Kola has been revered in Ayurvedic, Chinese, and Indonesian medicine for its wide range of therapeutic properties. Known as the "herb of longevity," it has been used to promote mental clarity, support skin health, and improve circulation.
In modern herbal medicine, Gotu Kola is often acclaimed for its potential cognitive and neuroprotective benefits. It's frequently studied for its ability to enhance memory, reduce anxiety, and support overall brain function. Additionally, the herb is noted for its wound-healing properties, which have been validated in various preclinical studies. This versatility makes Gotu Kola a valuable component in both traditional and contemporary health practices.
What is Gotu Kola used for, and what do the studies say?
Gotu Kola is used for a range of health benefits, particularly in the realms of cognitive enhancement, skin health, and circulatory support. In traditional medicine, Gotu Kola has long been utilized for its reputed ability to boost memory and mental clarity. Modern research corroborates some of these claims, highlighting its potential neuroprotective properties. For instance, a review published in "Trends in Food Science & Technology" emphasized Gotu Kola's ability to attenuate oxidative stress, regenerate neurons, and potentially reduce the accumulation of amyloid plaques, which are associated with neurodegenerative conditions (Sabaragamuwa et al., 2018).
Another significant application of Gotu Kola is in the treatment of chronic venous insufficiency (CVI). CVI is a condition characterized by poor blood flow in the veins, often leading to symptoms like leg pain, swelling, and varicose veins. Several studies have indicated that Gotu Kola can improve these symptoms. For example, a systematic review published in "The Cochrane Database of Systematic Reviews" noted that oral ingestion of Gotu Kola showed some global benefit in reducing edema in CVI patients, though more research is needed to fully confirm its efficacy (Martínez-Zapata et al., 2005).
Gotu Kola is also widely recognized for its wound-healing capabilities. The herb has been shown to promote collagen synthesis and stimulate fibroblast proliferation, which are crucial steps in the wound-healing process. A study published in the "Surabaya Physical Medicine and Rehabilitation Journal" documented the significant wound-healing effects of Gotu Kola extract in streptozotocin-induced diabetic rats, underscoring its potential in managing diabetic ulcers (Dewi et al., 2023).
Moreover, Gotu Kola exhibits anxiolytic properties, as evidenced by a double-blind, placebo-controlled study published in the "Journal of Clinical Psychopharmacology." The study demonstrated that Gotu Kola significantly attenuated the acoustic startle response in humans, indicating its potential to reduce anxiety (Bradwejn et al., 2000). These diverse applications make Gotu Kola a versatile and valuable herb in both traditional and modern medicinal practices.
How does Gotu Kola work?
Gotu Kola operates through a multifaceted mechanism, primarily involving its active compounds, which include triterpenoids, asiaticoside, madecassoside, and various flavonoids. These compounds collectively contribute to Gotu Kola's therapeutic effects, influencing several biological pathways.
One of the primary mechanisms by which Gotu Kola exerts its effects is through its neuroprotective properties. The herb has been shown to enhance memory and cognitive function by promoting the production of brain-derived neurotrophic factor (BDNF). BDNF is crucial for the survival, growth, and maintenance of neurons. A study published in the "Iranian Journal of Basic Medical Sciences" demonstrated that Gotu Kola ethanol extract up-regulates BDNF, tyrosine kinase B (TrkB), and extracellular signal-regulated protein kinase 1/2 (ERK1/2) signaling in a chronic electrical stress model in rats, thereby improving memory performance (Sari et al., 2019).
Another significant action of Gotu Kola is its ability to enhance microcirculation and reduce edema. This is particularly beneficial for individuals with chronic venous insufficiency. Gotu Kola improves blood flow by strengthening the walls of veins and capillaries, making them less susceptible to leakage and swelling. The herb's triterpenoids, especially asiaticoside, play a crucial role in this process by promoting collagen synthesis and enhancing the integrity of the vascular system. This was supported by a Cochrane review, which found some evidence of Gotu Kola's efficacy in reducing leg edema in patients with CVI (Martínez-Zapata et al., 2005).
Gotu Kola's wound-healing properties are another key aspect of its functionality. The herb promotes wound healing through several mechanisms, including the stimulation of fibroblast proliferation, collagen synthesis, and angiogenesis (the formation of new blood vessels). These processes are essential for tissue repair and regeneration. A study in the "Surabaya Physical Medicine and Rehabilitation Journal" highlighted the significant wound-healing effects of Gotu Kola extract in diabetic rats, attributing these benefits to the herb's ability to stimulate collagen production and enhance the wound-healing process (Dewi et al., 2023).
Lastly, Gotu Kola exhibits anxiolytic effects, which are believed to be mediated through its interaction with the central nervous system. The herb has been shown to modulate neurotransmitter levels, particularly those involved in anxiety and stress responses. A study published in the "Journal of Clinical Psychopharmacology" demonstrated that Gotu Kola significantly attenuated the acoustic startle response in humans, suggesting its potential to reduce anxiety by influencing neurotransmitter pathways (Bradwejn et al., 2000).
In summary, Gotu Kola works through a combination of neuroprotective, circulatory, wound-healing, and anxiolytic mechanisms, making it a versatile herb with wide-ranging therapeutic applications.
How is Gotu Kola used differently in men’s and women’s health?
Gotu Kola serves various health purposes for both men and women, but its applications can be tailored to address gender-specific health concerns. While the core benefits of cognitive enhancement, wound healing, and circulatory support apply universally, certain unique aspects make Gotu Kola particularly beneficial for men and women in different contexts.
For women, Gotu Kola is often used to support skin health and manage hormonal fluctuations. The herb's ability to promote collagen synthesis and improve skin elasticity makes it a popular choice for treating issues like cellulite, stretch marks, and varicose veins, which are more prevalent among women. A study published in "Frontiers in Pharmacology" highlights Gotu Kola's beneficial effects on skin health, attributing its efficacy to its anti-inflammatory and antioxidant properties (Sun et al., 2020). Additionally, Gotu Kola's anti-anxiety and mood-stabilizing effects can be beneficial for women experiencing hormonal imbalances, particularly during menstruation, pregnancy, or menopause.
In men’s health, Gotu Kola is often used to support cognitive function and manage stress. The cognitive-enhancing properties of Gotu Kola can be particularly beneficial for men facing high-stress environments or those looking to boost mental clarity and focus. A randomized controlled study published in the "Journal of Exercise Rehabilitation" found that Gotu Kola supplementation, combined with multicomponent exercise, improved cognitive function and reduced oxidative stress in older adults, which can be particularly beneficial for men experiencing age-related cognitive decline (Phoemsapthawee et al., 2022). Additionally, Gotu Kola's ability to reduce anxiety and improve mood can help men manage stress more effectively.
Moreover, Gotu Kola's circulatory benefits can be particularly advantageous for men who are at a higher risk of cardiovascular issues. The herb's ability to improve blood flow and reduce symptoms of chronic venous insufficiency can support overall cardiovascular health. A study published in the "International Journal of Research in Pharmaceutical Sciences" demonstrated that a combination of Gotu Kola and turmeric effectively reduced blood pressure and arterial stiffness in hypertensive rats, suggesting potential cardiovascular benefits for men (Mulyani et al., 2021).
While Gotu Kola offers valuable health benefits for both men and women, its applications can be tailored to address specific gender-related health concerns. Women may find it particularly beneficial for skin health and hormonal balance, while men might use it to enhance cognitive function and support cardiovascular health. This versatility makes Gotu Kola a valuable herb in gender-specific health practices.
How much Gotu Kola should I take?
The appropriate dosage of Gotu Kola can vary depending on the form in which it is consumed, the specific health condition being targeted, and individual factors like age, weight, and overall health status. Generally, Gotu Kola is available in several forms, including capsules, tablets, tinctures, and topical applications. The dosage guidelines can differ for each of these forms.
For oral supplementation, Gotu Kola is commonly available in capsule or tablet form. A typical dosage ranges from 300 mg to 500 mg of Gotu Kola extract taken two to three times daily. For instance, some studies have utilized dosages of around 500 mg twice a day to achieve cognitive and circulatory benefits. A study published in the "Journal of Exercise Rehabilitation" used a dosage of 500 mg of Gotu Kola extract twice daily in combination with exercise to improve cognitive function and reduce oxidative stress (Phoemsapthawee et al., 2022).
When using Gotu Kola tinctures, the standard dosage is usually about 30 to 60 drops diluted in water or another beverage, taken two to three times a day. Tinctures are often preferred for their ease of absorption and flexibility in adjusting the dosage. For dried Gotu Kola leaves or powdered forms, dosages can range from 1 to 2 grams per day, which can be consumed by mixing with water, juice, or adding to smoothies.
Topical applications of Gotu Kola, used for skin healing and wound treatment, typically involve creams or gels containing 1% to 2% Gotu Kola extract. These can be applied directly to the affected area two to three times daily. A study in the "Surabaya Physical Medicine and Rehabilitation Journal" demonstrated the efficacy of a topical gel with varying concentrations of Gotu Kola extract in promoting wound healing in diabetic rats (Dewi et al., 2023).
It is important to note that the optimal dosage can vary based on individual needs and the specific health condition being addressed. While the above guidelines provide a general framework, it is advisable to consult a healthcare professional for personalized recommendations. This ensures that the dosage is both safe and effective for your particular health scenario.
What are the main side effects of Gotu Kola?
Gotu Kola is generally considered safe for most people when used appropriately, but like any supplement, it can cause side effects in some individuals. These side effects are typically mild and may include gastrointestinal issues, skin reactions, and potential interactions with other medications.
One of the most common side effects associated with Gotu Kola is gastrointestinal discomfort. Some individuals may experience nausea, stomach upset, or diarrhea when taking Gotu Kola, especially in higher doses. To minimize the risk of gastrointestinal issues, it's often recommended to start with a lower dose and gradually increase it as your body adjusts.
Skin reactions are another potential side effect, particularly when Gotu Kola is used topically. Some people might experience allergic reactions, such as redness, itching, or rash, when applying Gotu Kola creams or gels to their skin. If you have sensitive skin or a history of allergic reactions, it's advisable to perform a patch test before using Gotu Kola topically. Apply a small amount of the product to a discreet area of your skin and wait 24 hours to see if any adverse reaction occurs.
Drowsiness is another reported side effect, especially when Gotu Kola is used for its anxiolytic properties. The herb's calming effects can sometimes lead to feelings of drowsiness or sedation, which might be undesirable if you need to remain alert. If you experience drowsiness, it's best to avoid activities that require full attention, such as driving or operating heavy machinery.
Moreover, Gotu Kola can interact with certain medications, potentially altering their effectiveness or increasing the risk of side effects. For instance, Gotu Kola may enhance the effects of sedatives or other medications that cause drowsiness. It's also important to exercise caution if you are taking medications for liver conditions, as Gotu Kola has been reported to affect liver enzymes in some cases.
Though rare, there are isolated reports of more serious side effects, such as liver toxicity, particularly with long-term use or high doses of Gotu Kola. This underscores the importance of adhering to recommended dosages and consulting a healthcare professional before starting any new supplement regimen, especially if you have pre-existing health conditions or are taking other medications.
In summary, while Gotu Kola is generally safe for most people, potential side effects like gastrointestinal discomfort, skin reactions, drowsiness, and interactions with medications should be considered. Always consult a healthcare provider for personalized advice and to mitigate any risks.
Who should not take Gotu Kola?
While Gotu Kola is generally safe for many individuals, certain groups should exercise caution or avoid using this herb altogether due to potential risks and interactions. People with specific health conditions, those taking certain medications, and particular life stages may necessitate extra caution.
Firstly, individuals with liver disease or a history of liver problems should avoid Gotu Kola. The herb has been reported to affect liver enzymes, which could exacerbate existing liver conditions or interact negatively with medications processed by the liver. A review published in "Frontiers in Pharmacology" highlighted the need for caution in individuals with liver conditions, as Gotu Kola can potentially induce hepatotoxicity in some cases (Sun et al., 2020).
Pregnant and breastfeeding women should also avoid using Gotu Kola unless specifically advised by a healthcare provider. There is limited research on the safety of Gotu Kola during pregnancy and lactation, and its effects on the developing fetus or nursing infant are not well understood. Given this lack of data, it's prudent to err on the side of caution and refrain from using the herb during these critical periods.
People taking certain medications should be cautious as well. Gotu Kola can interact with sedatives, anticonvulsants, and medications that affect the central nervous system, potentially enhancing their sedative effects. Additionally, individuals on medications that affect liver enzymes, such as certain anti-seizure drugs or statins, should be wary of potential interactions. A study in the "Journal of Clinical Psychopharmacology" noted that Gotu Kola's anxiolytic properties could amplify the effects of sedative medications, thereby necessitating careful monitoring (Bradwejn et al., 2000).
Individuals with a known allergy to plants in the Apiaceae family, which includes celery, carrots, and parsley, should also avoid Gotu Kola. Allergic reactions can manifest as skin rashes, itching, or more severe symptoms like difficulty breathing. If you have a history of plant allergies, it is advisable to consult an allergist or healthcare provider before using Gotu Kola.
Lastly, those with a history of skin conditions or sensitivities should be cautious when using Gotu Kola topically. While the herb is known for its wound-healing properties, it can cause allergic reactions in some individuals, leading to redness, itching, or dermatitis. Conducting a patch test prior to full application can help mitigate this risk.
In summary, individuals with liver disease, pregnant or breastfeeding women, those on certain medications, people with plant allergies, and those with sensitive skin should avoid or exercise caution when considering Gotu Kola. Consulting a healthcare professional for personalized advice is always the best approach to ensure safety and efficacy.
Are Gotu Kola supplements known to interact with any medications?
Yes, Gotu Kola supplements are known to interact with certain medications, which can either enhance or diminish their effects or increase the risk of adverse side effects. Understanding these potential interactions is crucial for anyone considering Gotu Kola as part of their health regimen.
One significant interaction is with sedative medications. Gotu Kola has anxiolytic properties that can potentially enhance the sedative effects of medications such as benzodiazepines (e.g., diazepam, lorazepam), barbiturates, and other central nervous system depressants. This could lead to increased drowsiness, dizziness, and impaired cognitive function. A study published in the "Journal of Clinical Psychopharmacology" demonstrated that Gotu Kola significantly attenuated the acoustic startle response in humans, indicating its potential to enhance the effects of sedatives (Bradwejn et al., 2000).
Gotu Kola may also interact with medications that affect the liver. The herb has been reported to influence liver enzymes, which could alter the metabolism and effectiveness of drugs processed by the liver. This includes medications such as certain anticonvulsants, statins, and anticoagulants. For instance, Gotu Kola might increase the risk of liver toxicity when taken with other hepatotoxic drugs. A review in "Frontiers in Pharmacology" emphasized the need for caution in individuals taking medications that affect liver enzymes, as Gotu Kola can potentially induce hepatotoxicity (Sun et al., 2020).
Antidiabetic medications are another category where interactions could occur. Gotu Kola has been shown to have antihyperglycemic effects, which might enhance the blood sugar-lowering effects of antidiabetic drugs, leading to hypoglycemia. If you are taking medications like metformin or insulin, it's essential to monitor your blood sugar levels closely and consult your healthcare provider for appropriate dosage adjustments.
Moreover, Gotu Kola may interact with diuretics. The herb has mild diuretic properties and, when combined with prescription diuretics, can potentially lead to an excessive loss of fluids and electrolytes. This could result in dehydration and electrolyte imbalances, which can have serious health implications.
Lastly, Gotu Kola may interact with anticoagulant and antiplatelet medications. The herb's potential to affect blood circulation and clotting mechanisms could either enhance the effects of these drugs or increase the risk of bleeding. If you are taking medications like warfarin, aspirin, or clopidogrel, it's important to discuss the use of Gotu Kola with your healthcare provider to avoid complications.
In summary, Gotu Kola supplements can interact with sedatives, liver-affecting medications, antidiabetic drugs, diuretics, and anticoagulant/antiplatelet medications. Given these potential interactions, consulting a healthcare professional before incorporating Gotu Kola into your regimen is essential to ensure safety and efficacy.
What are the best sources of Gotu Kola?
When seeking Gotu Kola supplements, it's essential to prioritize quality and purity to ensure you are getting the most benefit from this versatile herb. The best sources of Gotu Kola typically come from reputable manufacturers who adhere to stringent quality control standards and obtain their raw materials from trusted suppliers. Here are some guidelines to help you identify the best sources of Gotu Kola:
- Reputable Brands and Manufacturers: Look for well-established brands with a history of producing high-quality herbal supplements. Brands that have a good reputation in the industry are more likely to adhere to stringent manufacturing practices and quality control standards. Companies that are transparent about their sourcing and manufacturing processes are often more trustworthy.
- Certified Organic: Opt for Gotu Kola supplements that are certified organic. Organic certification ensures that the plant has been grown without the use of synthetic pesticides, herbicides, or fertilizers, which can compromise the quality and safety of the supplement. Organic Gotu Kola is also less likely to contain harmful contaminants.
- Third-Party Testing: Choose supplements that have been third-party tested for purity, potency, and safety. Third-party testing provides an additional layer of assurance that the product contains what it claims on the label and is free from contaminants such as heavy metals, pesticides, and microbial impurities. Look for products that display a third-party certification seal on their packaging.
- Standardized Extracts: For consistency and potency, select Gotu Kola supplements that contain standardized extracts. Standardization involves ensuring that the supplement contains a specific concentration of active compounds, such as triterpenoids or asiaticoside. This guarantees that you are receiving a consistent and effective dose with each serving.
- Form and Dosage: Gotu Kola is available in various forms, including capsules, tablets, tinctures, powders, and topical applications. Choose a form that best suits your needs and lifestyle. For instance, capsules and tablets offer convenience and precise dosing, while tinctures and powders provide flexibility in adjusting the dosage. Topical applications are ideal for skin health and wound healing.
- Transparent Labeling: Ensure that the product label provides comprehensive information about the supplement, including the botanical name (Centella asiatica), the part of the plant used (typically the leaves), the concentration of active compounds, and the recommended dosage. Transparent labeling indicates that the manufacturer is committed to providing high-quality products and values consumer trust.
- Positive Reviews and Testimonials: Check for customer reviews and testimonials to gauge the effectiveness and reliability of the Gotu Kola supplement. Positive feedback from other users can provide valuable insights into the product's quality and efficacy.
By prioritizing these factors, you can identify the best sources of Gotu Kola supplements that offer both safety and effectiveness. Always consult a healthcare professional before starting any new supplement to ensure it aligns with your individual health needs and conditions.
What forms does Gotu Kola come in?
Gotu Kola is available in various forms, each catering to different preferences and specific health needs. Understanding the different forms can help you choose the one that best fits your lifestyle and therapeutic goals. Here are the most common forms of Gotu Kola:
- Capsules and Tablets: These are among the most popular forms of Gotu Kola supplements due to their convenience and ease of use. Capsules and tablets provide a precise dosage, making it easy to monitor your intake. They are ideal for those who prefer a straightforward, no-fuss method of supplementation. Dosages typically range from 300 mg to 500 mg per capsule or tablet, taken two to three times daily.
- Tinctures: Gotu Kola tinctures are liquid extracts made by soaking the herb in alcohol or another solvent. Tinctures are highly concentrated and offer a flexible dosing option, as you can easily adjust the amount you take. They are often consumed by adding a few drops to water, juice, or tea. Tinctures are quickly absorbed by the body, making them a good option for those who need rapid effects.
- Powders: Gotu Kola powder is made from dried and ground leaves of the plant. This form allows for versatile use, as it can be added to smoothies, juices, teas, or even sprinkled on food. Powders offer the advantage of being easily adjustable in terms of dosage. They are also a cost-effective option for those who prefer bulk purchases.
- Teas and Infusions: Gotu Kola tea is made from the dried leaves of the plant and can be consumed as a warm or cold beverage. This form is popular in traditional medicine and offers a soothing way to incorporate Gotu Kola into your daily routine. Teabags and loose-leaf options are available, providing flexibility in preparation methods.
- Topical Creams and Gels: For skin health and wound healing, Gotu Kola is available in the form of topical creams and gels. These products are applied directly to the skin and are often used to treat conditions like eczema, psoriasis, varicose veins, and minor wounds. Topical applications typically contain 1% to 2% Gotu Kola extract and are applied two to three times daily to the affected area.
- Standardized Extracts: These are concentrated forms of Gotu Kola that contain a specific percentage of active compounds, such as triterpenoids or asiaticoside. Standardized extracts ensure consistency and potency, making them a reliable option for therapeutic use. They can be found in various forms, including capsules, tablets, and tinctures.
- Fresh or Dried Leaves: In some cultures, Gotu Kola is consumed fresh or dried as part of the diet. The leaves can be added to salads, soups, and other dishes. Fresh Gotu Kola leaves are often used in traditional Ayurvedic and Southeast Asian cuisine for their health benefits and flavor.
Each form of Gotu Kola has its unique advantages, and the choice depends on your specific needs and preferences. Whether you prefer the convenience of capsules, the versatility of powders, or the targeted application of topical creams, Gotu Kola offers a range of options to suit various health goals. Always consult with a healthcare professional to determine the most appropriate form and dosage for your individual needs.
Which sub-compounds of Gotu Kola, if any, are critical to the efficacy of Gotu Kola?
The efficacy of Gotu Kola can be largely attributed to its rich composition of bioactive compounds, particularly triterpenoids, saponins, and flavonoids. These sub-compounds play critical roles in mediating the herb's therapeutic effects. Understanding these key constituents can provide insight into how Gotu Kola works and why it is so effective for various health applications.
- Triterpenoids: Triterpenoids, including asiaticoside, madecassoside, asiatic acid, and madecassic acid, are among the most crucial compounds in Gotu Kola. These triterpenoids are primarily responsible for the herb's wound-healing and anti-inflammatory properties. Asiaticoside and madecassoside, in particular, have been shown to promote collagen synthesis, enhance fibroblast proliferation, and accelerate the wound-healing process. A study published in the "Surabaya Physical Medicine and Rehabilitation Journal" highlighted the significant wound-healing effects of Gotu Kola extract, attributing these benefits to triterpenoids (Dewi et al., 2023).
- Saponins: Saponins, another important class of compounds in Gotu Kola, contribute to its anti-inflammatory and antioxidant properties. These compounds help reduce oxidative stress and inflammation, which are critical factors in the management of various chronic conditions. Saponins also support the integrity of the vascular system, making them beneficial for conditions like chronic venous insufficiency (CVI). A Cochrane review noted the potential of Gotu Kola in reducing edema in CVI patients, which can be partly attributed to its saponin content (Martínez-Zapata et al., 2005).
- Flavonoids: Flavonoids are well-known for their antioxidant and neuroprotective properties. In Gotu Kola, flavonoids such as quercetin and kaempferol help scavenge free radicals, thereby reducing oxidative stress and protecting cells from damage. These compounds are particularly beneficial for cognitive health, as they can help improve memory, reduce anxiety, and support overall brain function. A study published in "Trends in Food Science & Technology" emphasized Gotu Kola's neuroprotective properties, highlighting the role of its flavonoid content in attenuating oxidative stress and promoting neuronal health (Sabaragamuwa et al., 2018).
- Asiatic Acid and Madecassic Acid: These specific triterpenoid compounds have been extensively studied for their anti-inflammatory and antioxidant effects. Asiatic acid, in particular, has been shown to inhibit the production of pro-inflammatory cytokines, thereby reducing inflammation. Madecassic acid also contributes to the anti-inflammatory effects of Gotu Kola and helps protect against oxidative damage.
- Phytosterols: Phytosterols in Gotu Kola contribute to its cholesterol-lowering and anti-inflammatory effects. These compounds can help modulate lipid levels in the body and reduce the risk of cardiovascular diseases.
- Polyphenols: Polyphenols, including catechins and tannins, are potent antioxidants that help neutralize free radicals and protect against cellular damage. These compounds enhance Gotu Kola's overall antioxidant capacity, making it effective in managing oxidative stress-related conditions.
In summary, the efficacy of Gotu Kola is primarily driven by its rich composition of triterpenoids, saponins, flavonoids, asiatic acid, madecassic acid, phytosterols, and polyphenols. These bioactive compounds work synergistically to provide a wide range of health benefits, including wound healing, anti-inflammatory effects, antioxidant protection, and neuroprotection. Understanding the roles of these sub-compounds can help you appreciate the multifaceted therapeutic potential of Gotu Kola.
What is Gotu Kola also known as?
Gotu Kola, scientifically known as Centella asiatica, is a versatile herb with a variety of names and terminologies associated with it. These names can vary based on geographical regions, languages, and traditional medicinal practices. Here is a comprehensive list of alternative names, common misspellings, abbreviations, and key chemical compounds and ingredients associated with Gotu Kola:
Common Names and Traditional Names:
- Asiatic Pennywort: A common name used in English-speaking regions.
- Mandukaparni: The name used in Ayurvedic medicine.
- Brahmi: Although 'Brahmi' typically refers to Bacopa monnieri, it is also sometimes used for Gotu Kola, particularly in India.
- Indian Pennywort: Another English name highlighting its origin and appearance.
- Marsh Pennywort: Refers to its preferred growing environment in marshy areas.
- Jal Brahmi: Used in some parts of India, linking it to water-related environments.
- Pegaga: The Malay name for Gotu Kola.
- Longevity Herb: Refers to its traditional use for promoting long life and vitality.
- Tiger Grass: Named after the observation that tigers in Asia rub against the plant to heal their wounds.
Common Misspellings and Abbreviations:
- Gotu Cola: A frequent misspelling due to the similarity in pronunciation.
- Goto Kola: Another common misspelling.
- Gotukola: Often written as a single word.
- GK: A simple abbreviation sometimes used in informal contexts.
Chemical Compounds and Key Ingredients:
- Triterpenoids:
- Asiaticoside: One of the main active components known for its wound-healing properties.
- Madecassoside: Another critical triterpenoid with anti-inflammatory and skin-healing benefits.
- Asiatic Acid: Known for its anti-inflammatory and neuroprotective properties.
- Madecassic Acid: Contributes to anti-inflammatory and antioxidant effects.
- Saponins: Contribute to the herb's anti-inflammatory and antioxidant activities.
- Flavonoids:
- Quercetin: A potent antioxidant that helps reduce oxidative stress.
- Kaempferol: Another antioxidant that supports overall cellular health.
- Phytosterols: Compounds that help modulate lipid levels and support cardiovascular health.
- Polyphenols:
- Catechins: Antioxidants that help neutralize free radicals.
- Tannins: Known for their astringent properties and antioxidant benefits.
Botanical and Scientific References:
- Centella asiatica (L.) Urban: The full scientific name, often used in research and botanical references.
- Hydrocotyle asiatica: An older botanical name that is sometimes still referenced in scientific literature.
Understanding the various names and components of Gotu Kola can help you recognize its presence in different products and contexts, ensuring you can identify and utilize this valuable herb effectively. Whether you encounter it as Centella asiatica in scientific studies or Pegaga in traditional Malaysian medicine, the multifaceted benefits of Gotu Kola remain consistent.
What is important to look for on the label of a Gotu Kola supplement to ensure product quality?
When choosing a Gotu Kola supplement, it's crucial to ensure that the product is of high quality, safe, and effective. The supplement market is vast, and not all products are created equal. Here are some key factors to look for on the label to ensure you're getting a high-quality Gotu Kola supplement:
- Botanical Name: Ensure that the label clearly states the botanical name Centella asiatica. This helps confirm that you are getting the correct herb, as common names can sometimes be misleading.
- Standardization: Look for supplements that mention standardization on the label. Standardized extracts ensure a consistent concentration of active compounds, such as triterpenoids (asiaticoside, madecassoside). This guarantees that each dose provides a reliable and effective amount of the active ingredients. For example, a label might state "standardized to contain 10% asiaticoside."
- Dosage and Potency: Check the dosage and potency of the supplement. The label should specify the amount of Gotu Kola extract per serving, typically ranging from 300 mg to 500 mg. It should also indicate the recommended daily dosage. Ensuring the correct dosage is crucial for achieving the desired therapeutic effects.
- Purity and Additives: Look for products that are free from unnecessary additives, fillers, binders, and artificial ingredients. The label should ideally state "No artificial colors, flavors, or preservatives." Additionally, check for information on allergens, ensuring the product is free from common allergens like gluten, soy, and dairy if needed.
- Third-Party Testing and Certifications: High-quality supplements often undergo third-party testing to verify their purity, potency, and safety. Look for labels that mention third-party testing or certifications from reputable organizations like NSF International, USP (United States Pharmacopeia), or ConsumerLab. These certifications indicate that the product has been independently tested and meets stringent quality standards.
- Organic Certification: If possible, choose certified organic Gotu Kola supplements. Organic certification ensures that the plant was grown without synthetic pesticides, herbicides, or fertilizers, reducing the risk of harmful contaminants. Look for labels with certifications from recognized organizations such as USDA Organic or EU Organic.
- Country of Origin: The country of origin can provide insights into the quality of the raw materials. Gotu Kola grown in reputable regions like India, Sri Lanka, or other parts of Southeast Asia, where it is traditionally harvested, is often of higher quality. The label should ideally mention the source of the raw material.
- Expiry Date and Batch Number: Ensure that the supplement has a clear expiry date to guarantee its potency and safety. A batch number is also useful for tracking the product in case of recalls or quality issues.
- Manufacturer Information: Reputable manufacturers are transparent about their contact information and manufacturing practices. The label should include the manufacturer's name, address, and contact details. This transparency indicates a commitment to quality and consumer trust.
- Usage Instructions and Warnings: The label should provide clear usage instructions, including the recommended dosage and any potential warnings or contraindications. This information is essential for safe and effective use of the supplement.
By paying attention to these details on the label, you can make an informed choice and select a high-quality Gotu Kola supplement that meets your health needs. Always consult with a healthcare professional before starting any new supplement to ensure it aligns with your individual health conditions and goals.
Disclaimer & References
The information provided on this website, including any text, images, or other material contained within, is for informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. This page was created by the SuppCo editiorial team, with AI summarization tools, including data from but not limited to following studies:
- M. Martínez-Zapata, X. Bonfill Cosp, Rosa Mª Moreno, E. Vargas, Dolors Capellà (2005). Phlebotonics for venous insufficiency.. The Cochrane database of systematic reviews, 3,
CD003229 . Link: 10.1002/14651858.cd003229.pub2 - R. Kolluri, Janice Chung, Sue Kim, Nibir Nath, B. B. Bhalla, Tarun Jain, J. Zygmunt, A. Davies (2020). Network meta-analysis to compare VenaSeal with other superficial venous therapies for chronic venous insufficiency.. Journal of vascular surgery. Venous and lymphatic disorders, , . Link: 10.1016/j.jvsv.2019.12.061
- J. Bradwejn, Yueping Zhou, D. Koszycki, J. Shlik (2000). A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects.. Journal of clinical psychopharmacology, 20 6,
680-4 . Link: 10.1097/00004714-200012000-00015 - I. D. A. S. Dewi, Nurmawati Fatimah, Sutji Kuswarini (2023). Effect of Topical Gel Ethanol Extract of Gotu Kola Leaf (Centella Asiatica (L.) Urban) on Wound Healing in a White Male Rat (Rattus Norvegicus) Induced by Streptozotocin. Surabaya Physical Medicine and Rehabilitation Journal, , . Link: 10.20473/spmrj.v5i2.47921
- Josicléia Leôncio da Silva, Ana Gonçalves Lima, Natália Ramos Diniz, J. Leite (2021). Effectiveness of therapeutic exercises for improving the quality of life of patients with chronic venous insufficiency: a systematic review. Jornal Vascular Brasileiro, 20, . Link: 10.1590/1677-5449.200248
- D. Janssens, Carine Michiels, Geneviève Guillaume, Bernard Cuisinier, Yves Louagie, J. Remacle (1999). Increase in circulating endothelial cells in patients with primary chronic venous insufficiency: protective effect of Ginkor Fort in a randomized double-blind, placebo-controlled clinical trial.. Journal of cardiovascular pharmacology, 33 1,
7-11 . Link: 10.1097/00005344-199901000-00002 - R. Sabaragamuwa, C. Perera, B. Fedrizzi (2018). Centella asiatica (Gotu kola) as a neuroprotectant and its potential role in healthy ageing. Trends in Food Science & Technology, , . Link: 10.1016/J.TIFS.2018.07.024
- Naphakorn Srichaiyo, S. Tongsiri, S. Hoseinifar, M. Dawood, S. Jaturasitha, M. Esteban, E. Ringø, H. Doan (2020). The effects gotu kola (Centella asiatica) powder on growth performance, skin mucus, and serum immunity of Nile tilapia (Oreochromis niloticus) fingerlings. Aquaculture Reports, 16, 100239. Link: 10.1016/j.aqrep.2019.100239
- G. Casili, M. Lanza, M. Campolo, S. Messina, S. Scuderi, Alessio Ardizzone, A. Filippone, I. Paterniti, S. Cuzzocrea, E. Esposito (2020). Therapeutic potential of flavonoids in the treatment of chronic venous insufficiency.. Vascular pharmacology, ,
106825 . Link: 10.1016/j.vph.2020.106825 - M. Azhdari, M. Zilaee, M. Karandish, S. Hosseini, Anahita Mansoori, M. Zendehdel, Sara Khodarahpour (2020). Red vine leaf extract (AS 195) can improve some signs and symptoms of chronic venous insufficiency, a systematic review. Phytotherapy Research, 34, 2577 - 2585. Link: 10.1002/ptr.6705
- Naphakorn Srichaiyo, S. Tongsiri, S. Hoseinifar, M. Dawood, S. Jaturasitha, M. Esteban, E. Ringø, H. Doan (2020). The effects gotu kola (Centella asiatica) powder on growth performance, skin mucus, and serum immunity of Nile tilapia (Oreochromis niloticus) fingerlings. Aquaculture Reports, 16, 100239. Link: 10.1016/j.aqrep.2019.100239
- Alan N. Talabani (2016). An In Vitro Evaluation of the Effectiveness of Gotu Kola (Centella asiatica) on Inhibiting the Growth of Selected Microorganisms in Human Saliva. Journal of baghdad college of dentistry, 28, 174-178. Link: 10.12816/0024730
- R. Sabaragamuwa, C. Perera, B. Fedrizzi (2018). Centella asiatica (Gotu kola) as a neuroprotectant and its potential role in healthy ageing. Trends in Food Science & Technology, , . Link: 10.1016/J.TIFS.2018.07.024
- J. Bradwejn, Yueping Zhou, D. Koszycki, J. Shlik (2000). A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects.. Journal of clinical psychopharmacology, 20 6,
680-4 . Link: 10.1097/00004714-200012000-00015 - I. D. A. S. Dewi, Nurmawati Fatimah, Sutji Kuswarini (2023). Effect of Topical Gel Ethanol Extract of Gotu Kola Leaf (Centella Asiatica (L.) Urban) on Wound Healing in a White Male Rat (Rattus Norvegicus) Induced by Streptozotocin. Surabaya Physical Medicine and Rehabilitation Journal, , . Link: 10.20473/spmrj.v5i2.47921
- Jatuporn Phoemsapthawee, Watthanaree Ammawat, Piyapong Prasertsri, Pakaporn Sathalalai, N. Leelayuwat (2022). Does Gotu kola supplementation improve cognitive function, inflammation, and oxidative stress more than multicomponent exercise alone? – a randomized controlled study. Journal of Exercise Rehabilitation, 18, 330 - 342. Link: 10.12965/jer.2244388.194
- (2023). Antimicrobial Activity of Gotu Kola (Centella asiatica) Leaf Extract as an Alternative to Herbal Beverage. Jurnal Biologi Tropis, , . Link: 10.29303/jbt.v23i2.4817
- Yani Mulyani, Patonah Hasimun, Hajar Sukmawati (2021). Effect of nori, a combination of turmeric (Curcuma longa) and gotu kola (Centella Asiatica) on blood pressure, modulation of ACE, eNOS and iNOS gene expression in hypertensive rats. International Journal of Research in Pharmaceutical Sciences, , . Link: 10.26452/ijrps.v12i4.4908
- D. C. R. Sari, N. Arfian, U. Tranggono, W. Setyaningsih, M. M. Romi, N. Emoto (2019). Centella asiatica (Gotu kola) ethanol extract up-regulates hippocampal brain-derived neurotrophic factor (BDNF), tyrosine kinase B (TrkB) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) signaling in chronic electrical stress model in rats. Iranian Journal of Basic Medical Sciences, 22, 1218 - 1224. Link: 10.22038/ijbms.2019.29012.7002
- S. Yuliani, Nikmawati Linar (2019). Effect of Gotu Kola (Centella asiatica) Extract Toward Expression of Caspase 3 of Hippocampus Pyramidal Cells on Dementia Model Rats Induced by Trimethyltin.. Proceedings of the 2019 Ahmad Dahlan International Conference Series on Pharmacy and Health Science (ADICS-PHS 2019), , . Link: 10.2991/adics-phs-19.2019.12
- Yanan Xu, Z. Cao, I. Khan, Yuan Luo (2008). Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide.. Journal of Alzheimer's disease : JAD, 13 3,
341-9 . Link: 10.3233/JAD-2008-13311 - Yani Mulyani, Patonah Hasimun, Hajar Sukmawati (2021). Effect of nori, a combination of turmeric (Curcuma longa) and gotu kola (Centella Asiatica) on blood pressure, modulation of ACE, eNOS and iNOS gene expression in hypertensive rats. International Journal of Research in Pharmaceutical Sciences, , . Link: 10.26452/ijrps.v12i4.4908
- S. M. Mas'adah, Sunarno, M. Djaelani (2019). Application of cinnamon and gotu kola supplements for increasing quail hematological status (Coturnixcoturnix-australica). Journal of Physics: Conference Series, 1217, . Link: 10.1088/1742-6596/1217/1/012163
- I. Damayanti, N. Antari, Sri Dewi Megayanti (2022). Antioxidant potential of gotu kola leaf extract (Centella asiatica (L.) Urban) as an alternative to antihyperglycemic herbal drinks. Jurnal Pijar Mipa, , . Link: 10.29303/jpm.v17i6.4179
- J. Bradwejn, Yueping Zhou, D. Koszycki, J. Shlik (2000). A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects.. Journal of clinical psychopharmacology, 20 6,
680-4 . Link: 10.1097/00004714-200012000-00015 - R. Sabaragamuwa, C. Perera, B. Fedrizzi (2018). Centella asiatica (Gotu kola) as a neuroprotectant and its potential role in healthy ageing. Trends in Food Science & Technology, , . Link: 10.1016/J.TIFS.2018.07.024
- I. D. A. S. Dewi, Nurmawati Fatimah, Sutji Kuswarini (2023). Effect of Topical Gel Ethanol Extract of Gotu Kola Leaf (Centella Asiatica (L.) Urban) on Wound Healing in a White Male Rat (Rattus Norvegicus) Induced by Streptozotocin. Surabaya Physical Medicine and Rehabilitation Journal, , . Link: 10.20473/spmrj.v5i2.47921
- Naphakorn Srichaiyo, S. Tongsiri, S. Hoseinifar, M. Dawood, S. Jaturasitha, M. Esteban, E. Ringø, H. Doan (2020). The effects gotu kola (Centella asiatica) powder on growth performance, skin mucus, and serum immunity of Nile tilapia (Oreochromis niloticus) fingerlings. Aquaculture Reports, 16, 100239. Link: 10.1016/j.aqrep.2019.100239
- I. Orhan (2012). Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential. Evidence-based Complementary and Alternative Medicine : eCAM, 2012, . Link: 10.1155/2012/946259
- Bo-ju Sun, Lili Wu, You Wu, Chengfei Zhang, Lingling Qin, Misa Hayashi, Maya Kudo, Ming Gao, Tonghua Liu (2020). Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review. Frontiers in Pharmacology, 11, . Link: 10.3389/fphar.2020.568032
- J. Bradwejn, Yueping Zhou, D. Koszycki, J. Shlik (2000). A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects.. Journal of clinical psychopharmacology, 20 6,
680-4 . Link: 10.1097/00004714-200012000-00015 - Jatuporn Phoemsapthawee, Watthanaree Ammawat, Piyapong Prasertsri, Pakaporn Sathalalai, N. Leelayuwat (2022). Does Gotu kola supplementation improve cognitive function, inflammation, and oxidative stress more than multicomponent exercise alone? – a randomized controlled study. Journal of Exercise Rehabilitation, 18, 330 - 342. Link: 10.12965/jer.2244388.194
- D. C. R. Sari, N. Arfian, U. Tranggono, W. Setyaningsih, M. M. Romi, N. Emoto (2019). Centella asiatica (Gotu kola) ethanol extract up-regulates hippocampal brain-derived neurotrophic factor (BDNF), tyrosine kinase B (TrkB) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) signaling in chronic electrical stress model in rats. Iranian Journal of Basic Medical Sciences, 22, 1218 - 1224. Link: 10.22038/ijbms.2019.29012.7002
- Yani Mulyani, Patonah Hasimun, Hajar Sukmawati (2021). Effect of nori, a combination of turmeric (Curcuma longa) and gotu kola (Centella Asiatica) on blood pressure, modulation of ACE, eNOS and iNOS gene expression in hypertensive rats. International Journal of Research in Pharmaceutical Sciences, , . Link: 10.26452/ijrps.v12i4.4908
- Bo-ju Sun, Lili Wu, You Wu, Chengfei Zhang, Lingling Qin, Misa Hayashi, Maya Kudo, Ming Gao, Tonghua Liu (2020). Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review. Frontiers in Pharmacology, 11, . Link: 10.3389/fphar.2020.568032
- Naphakorn Srichaiyo, S. Tongsiri, S. Hoseinifar, M. Dawood, S. Jaturasitha, M. Esteban, E. Ringø, H. Doan (2020). The effects gotu kola (Centella asiatica) powder on growth performance, skin mucus, and serum immunity of Nile tilapia (Oreochromis niloticus) fingerlings. Aquaculture Reports, 16, 100239. Link: 10.1016/j.aqrep.2019.100239
- I. Orhan (2012). Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential. Evidence-based Complementary and Alternative Medicine : eCAM, 2012, . Link: 10.1155/2012/946259
- Kun Marisa Farhana, R. Malueka, S. Wibowo, A. Gofir (2016). Effectiveness of Gotu Kola Extract 750 mg and 1000 mg Compared with Folic Acid 3 mg in Improving Vascular Cognitive Impairment after Stroke. Evidence-based Complementary and Alternative Medicine : eCAM, 2016, . Link: 10.1155/2016/2795915
- R. Sabaragamuwa, C. Perera, B. Fedrizzi (2018). Centella asiatica (Gotu kola) as a neuroprotectant and its potential role in healthy ageing. Trends in Food Science & Technology, , . Link: 10.1016/J.TIFS.2018.07.024
- Yanan Xu, Z. Cao, I. Khan, Yuan Luo (2008). Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide.. Journal of Alzheimer's disease : JAD, 13 3,
341-9 . Link: 10.3233/JAD-2008-13311 - Naphakorn Srichaiyo, S. Tongsiri, S. Hoseinifar, M. Dawood, S. Jaturasitha, M. Esteban, E. Ringø, H. Doan (2020). The effects gotu kola (Centella asiatica) powder on growth performance, skin mucus, and serum immunity of Nile tilapia (Oreochromis niloticus) fingerlings. Aquaculture Reports, 16, 100239. Link: 10.1016/j.aqrep.2019.100239
- J. Bradwejn, Yueping Zhou, D. Koszycki, J. Shlik (2000). A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects.. Journal of clinical psychopharmacology, 20 6,
680-4 . Link: 10.1097/00004714-200012000-00015 - Jatuporn Phoemsapthawee, Watthanaree Ammawat, Piyapong Prasertsri, Pakaporn Sathalalai, N. Leelayuwat (2022). Does Gotu kola supplementation improve cognitive function, inflammation, and oxidative stress more than multicomponent exercise alone? – a randomized controlled study. Journal of Exercise Rehabilitation, 18, 330 - 342. Link: 10.12965/jer.2244388.194
- I. Orhan (2012). Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential. Evidence-based Complementary and Alternative Medicine : eCAM, 2012, . Link: 10.1155/2012/946259
- I. D. A. S. Dewi, Nurmawati Fatimah, Sutji Kuswarini (2023). Effect of Topical Gel Ethanol Extract of Gotu Kola Leaf (Centella Asiatica (L.) Urban) on Wound Healing in a White Male Rat (Rattus Norvegicus) Induced by Streptozotocin. Surabaya Physical Medicine and Rehabilitation Journal, , . Link: 10.20473/spmrj.v5i2.47921
- Bo-ju Sun, Lili Wu, You Wu, Chengfei Zhang, Lingling Qin, Misa Hayashi, Maya Kudo, Ming Gao, Tonghua Liu (2020). Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review. Frontiers in Pharmacology, 11, . Link: 10.3389/fphar.2020.568032
- R. Sabaragamuwa, C. Perera, B. Fedrizzi (2018). Centella asiatica (Gotu kola) as a neuroprotectant and its potential role in healthy ageing. Trends in Food Science & Technology, , . Link: 10.1016/J.TIFS.2018.07.024
- Yanan Xu, Z. Cao, I. Khan, Yuan Luo (2008). Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide.. Journal of Alzheimer's disease : JAD, 13 3,
341-9 . Link: 10.3233/JAD-2008-13311 - U. Chandrika, Peramune A A S Prasad Kumarab (2015). Gotu Kola (Centella asiatica): Nutritional Properties and Plausible Health Benefits.. Advances in food and nutrition research, 76,
125-57 . Link: 10.1016/bs.afnr.2015.08.001 - (2023). Antimicrobial Activity of Gotu Kola (Centella asiatica) Leaf Extract as an Alternative to Herbal Beverage. Jurnal Biologi Tropis, , . Link: 10.29303/jbt.v23i2.4817
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