Coleus forskohlii, also known as Plectranthus barbatus, is a perennial herb that belongs to the Lamiaceae family. This plant is native to subtropical and tropical regions in India, Nepal, and Thailand. In traditional Ayurvedic medicine, it has been utilized for centuries due to its diverse medicinal properties. The plant is characterized by its vibrant green leaves and tubular flowers that range in color from lavender to blue.

The primary bioactive compound in Coleus forskohlii is forskolin, a labdane diterpene. Forskolin is found predominantly in the root tubers of the plant and is responsible for its pharmacological activity. This compound has been the subject of numerous studies and has shown potential in a variety of health applications. Forskolin has been traditionally used to treat ailments such as heart disease, respiratory disorders, and gastrointestinal issues.

In modern times, forskolin has gained attention for its potential benefits in weight management, cardiovascular health, and respiratory conditions. It is frequently included in dietary supplements aimed at promoting fat loss, boosting testosterone, and improving metabolic functions. The growing body of research supports its multifaceted applications, making Coleus forskohlii a valuable plant in both traditional and contemporary medicine.

Coleus forskohlii has a rich history in traditional medicine, particularly within Ayurvedic practices, where it has been used to treat a variety of ailments. Modern research has validated several of its traditional uses and unearthed new potential benefits. The primary active compound, forskolin, is credited with most of the plant's therapeutic effects.

One of the most well-documented uses of Coleus forskohlii is in the management of respiratory conditions like asthma. Studies have shown that forskolin can help alleviate asthma symptoms by modulating inflammation and promoting bronchodilation. For instance, a study published in the Journal of Cellular Biochemistry demonstrated that Coleus forskohlii extract significantly reduced airway inflammation and remodeling in an animal model of asthma, suggesting its potential as a supportive treatment for this condition.

Another significant application of Coleus forskohlii is in the realm of weight management and metabolic health. While the evidence is mixed, some studies suggest that forskolin can aid in fat loss, particularly in men. A randomized controlled trial published in Nutrients found that supplementation with Coleus forskohlii extract, combined with a hypocaloric diet, helped reduce waist and hip circumference and improved metabolic parameters in overweight and obese individuals. However, other studies have reported less dramatic results, indicating that more research is needed to fully understand its efficacy in weight loss.

In addition to respiratory and metabolic health, Coleus forskohlii has shown promise in lowering intraocular pressure, making it potentially useful in the management of glaucoma. Research published in Investigative Ophthalmology & Visual Science found that forskolin effectively reduced intraocular pressure in animal models without causing tolerance, suggesting its potential as a novel antiglaucoma agent.

Moreover, Coleus forskohlii has been studied for its cardiovascular benefits. Forskolin has been shown to lower blood pressure by relaxing vascular smooth muscle. A study in the Journal of Ethnopharmacology highlighted its potential to lower blood pressure and provide a positive inotropic effect on the heart, supporting its traditional use in treating cardiovascular disorders.

Overall, Coleus forskohlii presents a wide range of potential health benefits, supported by both traditional use and modern research. However, while promising, these findings often call for further clinical trials to confirm efficacy and establish standardized dosing guidelines.

Coleus forskohlii primarily exerts its effects through its active compound, forskolin. Forskolin is a labdane diterpene that has been extensively studied for its role in modulating various physiological processes. The most notable mechanism of action involves the activation of the enzyme adenylate cyclase, which in turn increases the levels of cyclic adenosine monophosphate (cAMP) within cells.

cAMP is a critical second messenger in numerous cellular pathways. By elevating cAMP levels, forskolin can influence various biological responses. For instance, in the context of respiratory health, increased cAMP levels can lead to bronchodilation, which helps in alleviating symptoms of asthma. This is supported by studies like the one published in the Journal of Cellular Biochemistry, which demonstrated that Coleus forskohlii extract can significantly reduce airway inflammation and remodeling in animal models of asthma.

In terms of weight management and metabolic health, forskolin's ability to elevate cAMP levels can stimulate lipolysis, the breakdown of fat stores in adipocytes (fat cells). This process helps in reducing body fat and improving metabolic parameters. Research published in Nutrients indicated that Coleus forskohlii extract, when combined with a hypocaloric diet, could help reduce waist and hip circumference and improve metabolic health markers in overweight and obese individuals.

Forskolin also has significant implications for cardiovascular health. By increasing cAMP levels in vascular smooth muscle cells, forskolin induces vasodilation, which can lower blood pressure. This mechanism has been explored in studies like the one published in the Journal of Ethnopharmacology, where forskolin was shown to relax vascular smooth muscle and reduce blood pressure in animal models.

Additionally, forskolin's ability to raise cAMP levels can benefit ocular health by reducing intraocular pressure (IOP), making it a potential treatment for glaucoma. Research in Investigative Ophthalmology & Visual Science found that forskolin lowered IOP in animal models by reducing the production of aqueous humor, without causing tolerance.

In summary, Coleus forskohlii works through its active compound forskolin, which activates adenylate cyclase and increases cAMP levels. This elevation in cAMP can lead to a variety of beneficial physiological effects, including bronchodilation, enhanced lipolysis, vasodilation, and reduced intraocular pressure. These mechanisms underpin the diverse therapeutic potential of Coleus forskohlii in respiratory, metabolic, cardiovascular, and ocular health.

Coleus forskohlii appears to have diverse applications in both men’s and women’s health, with some nuanced differences in how it is utilized and its effects based on gender. The primary active compound, forskolin, has been studied for its effects on various health conditions, but some evidence suggests that its benefits might manifest differently in men and women.

In men’s health, Coleus forskohlii is often highlighted for its potential to boost testosterone levels and support weight management. Some studies have suggested that forskolin supplementation can increase serum testosterone levels, which may contribute to improved body composition, muscle mass, and overall metabolic health. For instance, a study published in Obesity Research found that men who took Coleus forskohlii extract experienced significant increases in testosterone levels and reductions in body fat percentage compared to a placebo group. This makes the supplement particularly appealing for men looking to enhance muscle mass and reduce fat as part of their fitness regimen.

For women, the evidence on weight management is more mixed. While some studies suggest potential benefits, others indicate that the effects might not be as pronounced as in men. For example, research published in the Journal of the International Society of Sports Nutrition found that Coleus forskohlii supplementation did not significantly promote weight loss in overweight women but did help mitigate weight gain. This suggests that while it may not be as effective for fat loss in women, it could still offer benefits in maintaining body weight and preventing further weight gain.

In women’s health, Coleus forskohlii may also be used to address hormonal imbalances, particularly those related to metabolic syndrome and polycystic ovary syndrome (PCOS). By potentially improving insulin sensitivity and reducing metabolic risk factors, forskolin could help manage symptoms associated with these conditions. However, more research specific to these applications in women is needed to draw definitive conclusions.

Both men and women may benefit from the cardiovascular and respiratory health benefits of Coleus forskohlii. Forskolin’s ability to lower blood pressure and improve heart function, as shown in studies like those published in the Journal of Ethnopharmacology, is beneficial regardless of gender. Similarly, its potential to alleviate asthma symptoms through bronchodilation and anti-inflammatory effects is universally applicable.

In summary, while Coleus forskohlii offers a range of health benefits for both men and women, its effects on testosterone levels and weight management may be more pronounced in men. Women, on the other hand, might find it useful for maintaining body weight and potentially managing hormonal imbalances related to metabolic health. Both genders can benefit from its cardiovascular and respiratory health properties.

Determining the appropriate dosage of Coleus forskohlii largely depends on the specific health goals and the form in which the supplement is taken. The most common form used in studies and supplements is an extract standardized to contain a specific percentage of forskolin, usually ranging from 10% to 20%.

For general health and metabolic support, many studies have used a dosage of 250 mg of Coleus forskohlii extract standardized to 10% forskolin, taken twice daily. This dosage has been shown to be effective in various studies without causing significant side effects. For instance, a randomized controlled trial published in Nutrients used this dosage to evaluate its effects on metabolic parameters and found it to be beneficial in managing metabolic risk factors in overweight and obese individuals.

When targeting weight management specifically, the same dosage of 250 mg of a 10% forskolin extract twice daily has been frequently employed. This has been shown to help reduce body fat and improve body composition in some studies, particularly in men. However, it is important to note that individual responses can vary, and some people may require adjustments in dosage based on their specific needs and how they respond to the supplement.

For respiratory health, including the management of asthma symptoms, the dosages used may vary. Some studies have explored the use of Coleus forskohlii extracts in different forms, such as inhalers or oral supplements, to assess their efficacy in alleviating asthma symptoms. A study published in the Journal of Cellular Biochemistry highlighted the anti-inflammatory and bronchodilatory effects of Coleus forskohlii, which can be beneficial at dosages similar to those used for metabolic support.

In cardiovascular health, forskolin's ability to lower blood pressure and improve heart function has been studied at similar dosages. Research in the Journal of Ethnopharmacology has indicated that these dosages can effectively promote vasodilation and lower blood pressure, making them useful for heart health.

It is essential to follow the dosage recommendations provided by the manufacturer of the specific supplement being used, as formulations can vary. Additionally, starting with a lower dose and gradually increasing it can help gauge individual tolerance and effectiveness. While the above dosages are commonly used in studies, consulting with a healthcare provider for personalized advice is always a prudent approach, especially if you have underlying health conditions or are taking other medications.

While Coleus forskohlii is generally considered safe for most individuals when taken at recommended dosages, it can cause some side effects in certain people. These side effects can vary in severity and occurrence depending on individual sensitivity, dosage, and duration of use.

One of the most commonly reported side effects is gastrointestinal discomfort. Some individuals may experience symptoms such as nausea, diarrhea, or stomach cramps. These effects are typically mild and often resolve on their own as the body adjusts to the supplement. If gastrointestinal issues persist, it may be helpful to take the supplement with food or to divide the dosage throughout the day.

Another potential side effect is low blood pressure, also known as hypotension. Forskolin has vasodilatory properties that can lower blood pressure, which is beneficial for those with hypertension but may cause dizziness, lightheadedness, or fainting in people with normal or low blood pressure. It is essential for individuals with preexisting low blood pressure or those taking medications for hypertension to monitor their blood pressure closely while using Coleus forskohlii.

Coleus forskohlii may also affect heart rate. Some users have reported an increased heart rate (tachycardia) or palpitations. While these effects are usually transient and not severe, they can be concerning for individuals with cardiovascular conditions or those taking medications that influence heart rate.

Allergic reactions, although rare, can occur. Symptoms of an allergic reaction might include rash, itching, swelling, or difficulty breathing. If any of these symptoms occur, it is crucial to discontinue use immediately and seek medical attention.

Forskolin’s impact on blood clotting is another consideration. It has been shown to inhibit platelet aggregation, which can be beneficial for cardiovascular health but may increase the risk of bleeding or bruising, particularly in individuals taking blood-thinning medications or those with bleeding disorders.

In summary, while Coleus forskohlii is generally well-tolerated, it can cause side effects such as gastrointestinal discomfort, low blood pressure, increased heart rate, allergic reactions, and an increased risk of bleeding. Most side effects are mild and manageable, but it is essential to monitor for any adverse reactions, especially if you have underlying health conditions or are taking other medications. Consulting with a healthcare provider before starting Coleus forskohlii can help mitigate potential risks and ensure safe usage.

While Coleus forskohlii is generally safe for most individuals, certain groups of people should exercise caution or avoid using it altogether due to potential risks and interactions. Understanding who should not take Coleus forskohlii can help prevent adverse effects and ensure safe supplementation.

Individuals with low blood pressure (hypotension) or those prone to hypotensive episodes should be cautious when considering Coleus forskohlii. The active compound forskolin can lower blood pressure due to its vasodilatory effects, which may exacerbate symptoms like dizziness, lightheadedness, or fainting in those already experiencing low blood pressure. Such individuals should consult a healthcare provider before using Coleus forskohlii to avoid complications.

People with cardiovascular conditions, particularly those with heart rhythm disorders, should also be wary. Forskolin can increase heart rate and potentially cause palpitations. For those with preexisting cardiovascular issues or on medications that affect heart function, the use of Coleus forskohlii should be closely monitored by a healthcare professional to mitigate any risks.

Individuals on blood-thinning medications or those with bleeding disorders should avoid Coleus forskohlii due to its potential to inhibit platelet aggregation. This effect can increase the risk of bleeding and bruising, making it unsafe for those on anticoagulants like warfarin, clopidogrel, or aspirin, as well as individuals with conditions that affect blood clotting.

Pregnant and breastfeeding women should avoid using Coleus forskohlii due to the lack of sufficient research on its safety in these populations. The potential effects on fetal development and lactation are not well understood, so it is prudent to refrain from using the supplement during these periods.

People scheduled for surgery should discontinue the use of Coleus forskohlii at least two weeks before the procedure. Due to its effects on blood clotting and potential interactions with anesthesia, continuing the supplement could increase the risk of excessive bleeding and complications during surgery.

Lastly, individuals with known allergies to Coleus forskohlii or any of its components should avoid using the supplement. Allergic reactions, although rare, can occur and may include symptoms like rash, itching, swelling, or difficulty breathing.

In summary, Coleus forskohlii should be avoided by individuals with low blood pressure, cardiovascular conditions, those on blood-thinning medications, pregnant or breastfeeding women, people scheduled for surgery, and those with known allergies to the plant. Consulting with a healthcare provider before starting Coleus forskohlii can help ensure it is safe and appropriate for your specific health needs.

Yes, Coleus forskohlii supplements are known to interact with certain medications, which can alter their effectiveness or increase the risk of adverse effects. Understanding these potential interactions is crucial for ensuring safe use, especially if you are currently taking other medications.

One notable interaction is with blood pressure medications. Forskolin, the active compound in Coleus forskohlii, can lower blood pressure by relaxing blood vessels. This can have an additive effect when taken with antihypertensive drugs, potentially leading to excessively low blood pressure. Medications such as beta-blockers, ACE inhibitors, and calcium channel blockers could interact with forskolin, necessitating close monitoring and possible dosage adjustments by a healthcare provider.

Coleus forskohlii also interacts with anticoagulant and antiplatelet medications. Forskolin has been shown to inhibit platelet aggregation, which can enhance the effects of blood-thinning drugs and increase the risk of bleeding and bruising. Medications such as warfarin, clopidogrel, aspirin, and other nonsteroidal anti-inflammatory drugs (NSAIDs) can interact with Coleus forskohlii, making it essential to consult with a healthcare provider before combining these treatments.

Another area of concern is its interaction with medications that affect heart rate. Forskolin can increase heart rate, which may be problematic for individuals on medications that influence cardiac rhythm. Drugs such as digoxin and certain antiarrhythmic medications may interact with forskolin, potentially leading to adverse cardiovascular effects. Individuals with heart conditions should be particularly cautious and seek medical advice before using Coleus forskohlii.

Additionally, Coleus forskohlii may interact with medications for diabetes. Forskolin can influence blood sugar levels, and when taken with antidiabetic drugs, it could lead to hypoglycemia (low blood sugar). Medications such as insulin, metformin, and sulfonylureas may require dosage adjustments if Coleus forskohlii is introduced into the regimen. Regular monitoring of blood sugar levels is recommended to avoid any complications.

Lastly, individuals taking medications metabolized by the liver's cytochrome P450 enzyme system should be aware of potential interactions. Forskolin may influence the activity of these enzymes, altering the metabolism of various drugs. This can affect the efficacy and safety of medications such as statins, certain antidepressants, and immunosuppressants. Consulting with a healthcare provider can help identify any specific risks based on the medications being taken.

In summary, Coleus forskohlii supplements can interact with blood pressure medications, anticoagulants, heart rate medications, antidiabetic drugs, and medications metabolized by the cytochrome P450 enzyme system. To ensure safety, it is essential to consult with a healthcare provider before starting Coleus forskohlii, especially if you are taking any of these medications or have underlying health conditions.

When looking for the best sources of Coleus forskohlii, it is essential to consider factors such as quality, purity, and standardized extracts. The following guidelines can help you identify high-quality sources of Coleus forskohlii supplements:

1. Standardized Extracts: The most reliable sources of Coleus forskohlii are those that provide standardized extracts. This means the product has a consistent concentration of the active compound, forskolin—typically standardized to 10% or 20% forskolin. Standardization ensures that each dose contains the same amount of active ingredient, which is crucial for efficacy and safety. Look for labels that clearly state the forskolin content.
2. Reputable Brands: Choose supplements from reputable brands that have a history of quality and transparency. Brands that follow Good Manufacturing Practices (GMP) and have third-party testing for quality assurance are generally more reliable. Third-party testing ensures that the product is free from contaminants and accurately labeled in terms of ingredient concentrations.
3. Certifications and Quality Marks: Products that have certifications from recognized organizations, such as the United States Pharmacopeia (USP), NSF International, or ConsumerLab, provide additional assurance of quality. These certifications indicate that the product has been tested for purity, potency, and manufacturing standards.
4. Natural and Organic Sources: Whenever possible, opt for natural and organically grown Coleus forskohlii. Organic farming practices reduce the risk of exposure to pesticides and other harmful chemicals. Organic supplements are often free from synthetic additives and fillers, making them a safer choice for long-term use.
5. Transparent Labeling: High-quality supplements will have transparent labeling that includes information about the source of the Coleus forskohlii, the extraction method used, and the specific amount of forskolin per serving. Avoid products with vague labels or those that do not provide detailed information about their ingredients.
6. Customer Reviews and Recommendations: Reading customer reviews and recommendations can provide insights into the effectiveness and reliability of a particular product. Look for reviews from verified purchasers and consider feedback on the product’s efficacy, ease of use, and any side effects experienced.
7. Professional Recommendations: Consulting with healthcare providers or nutritionists can also help identify reputable sources of Coleus forskohlii. Professionals can recommend brands and products based on their experience and knowledge of quality standards in the supplement industry.

In summary, the best sources of Coleus forskohlii are those that offer standardized extracts, come from reputable brands, have relevant certifications, use natural and organic ingredients, provide transparent labeling, and receive positive customer reviews. By following these guidelines, you can ensure that you are obtaining a high-quality product that is both safe and effective.

Coleus forskohlii is available in several forms to cater to different preferences and needs. Each form has its unique advantages and considerations, making it important to choose the one that best suits your specific health goals and lifestyle. Here are the most common forms of Coleus forskohlii:

1. Capsules and Tablets:
   • Capsules and tablets are among the most popular forms of Coleus forskohlii supplements. They are convenient, easy to dose, and widely available. These forms usually contain a standardized extract of forskolin, ensuring consistent potency. Capsules and tablets often come in various strengths, typically ranging from 125 mg to 500 mg, with forskolin content standardized to 10% or 20%.
   • Advantages: Easy to take, consistent dosing, portable, and long shelf life.
   • Considerations: Some individuals may find swallowing capsules or tablets difficult.
2. Powder:
   • Coleus forskohlii powder is another versatile form that can be mixed into beverages, smoothies, or food. This form allows for flexible dosing and can be a good option for those who prefer not to take capsules or tablets.
   • Advantages: Flexible dosing, can be mixed with food or drinks, often more cost-effective.
   • Considerations: Requires measuring and mixing, which can be less convenient than capsules or tablets.
3. Liquid Extracts and Tinctures:
   • Liquid extracts and tinctures offer a highly concentrated form of Coleus forskohlii that can be taken directly or added to water, juice, or other liquids. These forms are quickly absorbed by the body and allow for precise dosing adjustments.
   • Advantages: Rapid absorption, easy to adjust dosage, can be added to beverages.
   • Considerations: May have a strong taste, requires careful measuring.
4. Topical Applications:
   • Topical creams and gels containing forskolin are used primarily for skin-related benefits, such as improving skin tone and reducing cellulite. These products are applied directly to the skin and absorbed locally.
   • Advantages: Targeted application, potential skin benefits.
   • Considerations: Limited to topical use, effects may vary based on formulation and skin type.
5. Inhalers and Nebulizers:
   • Inhalers and nebulizers containing Coleus forskohlii extracts are used for respiratory conditions like asthma. These forms deliver the active compound directly to the lungs, providing quick relief from symptoms.
   • Advantages: Direct delivery to the respiratory system, rapid onset of action.
   • Considerations: Requires specific equipment, primarily used for respiratory health.
6. Ophthalmic Solutions:
   • Ophthalmic solutions or eye drops containing forskolin are used to lower intraocular pressure in conditions such as glaucoma. These drops are applied directly to the eyes.
   • Advantages: Direct application to the eyes, effective for reducing intraocular pressure.
   • Considerations: Requires careful administration, limited to ocular use.

In summary, Coleus forskohlii is available in various forms, including capsules, tablets, powder, liquid extracts, topical applications, inhalers, and ophthalmic solutions. Each form offers unique benefits and considerations, making it important to choose the one that aligns with your specific health needs and preferences. Whether you seek convenience, flexible dosing, or targeted application, there is likely a form of Coleus forskohlii that suits your requirements.

The primary bioactive compound in Coleus forskohlii that is critical to its efficacy is forskolin. Forskolin is a labdane diterpene that has been extensively studied for its wide range of physiological effects and therapeutic potential. However, Coleus forskohlii also contains several other compounds that may contribute to its overall efficacy, though forskolin remains the most significant.

Forskolin:

• Forskolin is the main active compound responsible for many of the health benefits associated with Coleus forskohlii. It works by activating the enzyme adenylate cyclase, which increases the levels of cyclic adenosine monophosphate (cAMP) within cells. Elevated cAMP levels can lead to various beneficial effects, including bronchodilation, enhanced lipolysis, vasodilation, and reduced intraocular pressure. Forskolin's broad spectrum of action underpins its use in respiratory, metabolic, cardiovascular, and ocular health.
• Forskolin has demonstrated efficacy in numerous studies, such as those published in Nutrients and Investigative Ophthalmology & Visual Science, which highlight its potential in weight management, asthma relief, and glaucoma treatment.

Other Sub-Compounds:

• While forskolin is the most studied and potent compound, Coleus forskohlii contains other bioactive constituents that may also play a role in its therapeutic properties. These include various essential oils, flavonoids, and phenolic compounds.

1. Essential Oils:
   • Coleus forskohlii contains essential oils that contribute to its aromatic properties and may possess antimicrobial and anti-inflammatory effects. These oils have been studied for their potential to inhibit the growth of certain bacteria and fungi, which could support overall health and well-being.
2. Flavonoids:
   • Flavonoids are a group of polyphenolic compounds known for their antioxidant properties. While the concentration of flavonoids in Coleus forskohlii is not as high as in other plants, they may still contribute to the plant's overall antioxidant capacity, helping to neutralize free radicals and reduce oxidative stress.
3. Phenolic Compounds:
   • Phenolic compounds, like rosmarinic acid and caffeic acid, are also present in Coleus forskohlii. These compounds exhibit antioxidant and anti-inflammatory properties, which can complement the effects of forskolin and contribute to the plant's overall health benefits.

While forskolin remains the star player in Coleus forskohlii’s pharmacological profile, these additional compounds may enhance its efficacy through synergistic effects. The combined action of these bioactive constituents can contribute to the holistic benefits of Coleus forskohlii, making it a versatile and valuable medicinal plant.

In conclusion, forskolin is the critical sub-compound in Coleus forskohlii, responsible for its primary health benefits. However, other compounds such as essential oils, flavonoids, and phenolic compounds may also contribute to its overall efficacy, supporting a wide range of therapeutic applications. Understanding the role of these sub-compounds can provide a more comprehensive view of how Coleus forskohlii works and its potential health benefits.

Coleus forskohlii is known by several names, reflecting its diverse use in traditional medicine and modern supplements. Understanding these various names and terms can help identify the plant in different contexts and avoid confusion. Here are the common names, abbreviations, misspellings, and related chemical compounds:

Common Names and Synonyms:

1. Plectranthus barbatus: This is the scientific synonym for Coleus forskohlii. The plant is often referred to by this name in botanical and horticultural contexts.
2. Indian Coleus: This name highlights the plant's origin and traditional use in Indian medicine.
3. Makandi: A regional name used in parts of India.
4. Forskolin Plant: Named after its primary active compound, forskolin.

Common Misspellings:

1. Coleus forskohlii: The correct spelling.
2. Coleus forskohli: A common misspelling missing the second "i".
3. Coleus forskolli: Another misspelling with a single "h" and double "l".
4. Coleus forskohlli: A misspelling with an additional "l".

Abbreviations:

1. CF: Often used as a shorthand in scientific literature and supplement labels.
2. C. forskohlii: Another common abbreviation used in botanical and medical texts.

Related Chemical Compounds and Ingredients:

1. Forskolin: The primary active compound responsible for most of the plant's pharmacological effects. It is a labdane diterpene that activates adenylate cyclase, increasing cAMP levels in cells.
2. Isoforskolin (ISOF): A related diterpene found in some varieties of Coleus forskohlii, particularly those from Yunnan, China. Isoforskolin shares some biological activities with forskolin.
3. Essential Oils: Various essential oils present in the plant contribute to its aromatic properties and may have antimicrobial and anti-inflammatory effects.
4. Flavonoids: Polyphenolic compounds known for their antioxidant properties.
5. Phenolic Compounds: Includes rosmarinic acid and caffeic acid, which have antioxidant and anti-inflammatory properties.

Other Names in Traditional Medicine:

1. Patta Coleus: A name used in certain regions to refer to the plant.
2. Forskohlii: Sometimes simply referred to by its primary active compound.

Commercial Product Names:

1. ForsLean®: A branded form of Coleus forskohlii extract standardized to contain a specific percentage of forskolin, often used in weight management supplements.
2. Forskolii Extract: Another commercial name emphasizing the extract form of the compound.

In summary, Coleus forskohlii is known by various names, including Plectranthus barbatus and Indian Coleus, and is often referred to by its active compound, forskolin. Common misspellings include Coleus forskohli and Coleus forskolli, while abbreviations such as CF and C. forskohlii are frequently used in scientific literature. Understanding these different names and terms can help ensure accurate identification and use of Coleus forskohlii in both traditional and modern contexts.

When selecting a Coleus forskohlii supplement, it’s crucial to scrutinize the product label to ensure you’re getting a high-quality, effective, and safe product. Here are key factors to look for on the label:

Standardization of Forskolin Content:

1. Forskolin Percentage: The most critical aspect is the standardization of forskolin. Look for a product that specifies the percentage of forskolin, typically 10% or 20%. Standardization ensures that the supplement delivers a consistent and effective dose of the active compound.
2. Exact Dosage: The label should clearly indicate the amount of Coleus forskohlii extract per serving and the amount of forskolin it provides. For example, a product might state “250 mg of Coleus forskohlii extract standardized to 20% forskolin, providing 50 mg of forskolin per serving.”

Quality Certifications:

3. Third-Party Testing: Look for supplements that have been tested by independent third-party organizations. Certifications from reputable bodies like the United States Pharmacopeia (USP), NSF International, or ConsumerLab provide assurance that the product meets high standards for purity, potency, and safety.
4. Good Manufacturing Practices (GMP): Ensure the product is manufactured in a facility that follows Good Manufacturing Practices. GMP certification indicates that the manufacturer adheres to strict quality control standards.

Ingredient Transparency:

5. Full Ingredient List: The label should provide a comprehensive list of all ingredients, including any fillers, binders, or additives. Avoid products with unspecified “proprietary blends” where the exact amounts of ingredients are not disclosed.
6. Natural and Organic Ingredients: If possible, choose products that use natural or organically sourced Coleus forskohlii. Organic certification ensures that the plant was grown without harmful pesticides or chemicals.

Potential Allergens and Additives:

7. Allergen Information: Check for common allergens like gluten, soy, dairy, or artificial additives that you may want to avoid.
8. Additives and Preservatives: Opt for products with minimal additives and preservatives. Avoid supplements with artificial colors, flavors, or sweeteners.

Manufacturer Information:

9. Reputable Brand: Choose supplements from reputable brands known for their quality and transparency. Research the manufacturer to ensure they have a good track record and positive reviews.
10. Contact Information: The label should provide the manufacturer’s contact information, including address and customer service details. Transparency from the company is a good indicator of quality and accountability.

Usage Instructions and Warnings:

11. Dosage Instructions: Clear instructions on how to take the supplement, including the recommended dosage and any specific usage guidelines, should be present on the label.
12. Warnings and Precautions: Look for any warnings or precautions, especially if you have underlying health conditions or are taking other medications. This information can help you assess if the supplement is safe for you to use.

Expiration Date and Lot Number:

13. Expiration Date: Ensure the product has an expiration date, indicating its shelf life and potency.
14. Lot Number: The presence of a lot number allows for traceability and indicates good manufacturing practices.

In summary, when choosing a Coleus forskohlii supplement, look for standardized forskolin content, quality certifications, transparent ingredient lists, allergen and additive information, reputable manufacturer details, clear usage instructions, and an expiration date. These factors will help ensure that you are purchasing a high-quality, effective, and safe supplement.

The information provided on this website, including any text, images, or other material contained within, is for informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. This page was created by the SuppCo editiorial team, with AI summarization tools, including data from but not limited to following studies:

1. L. J. Valdés, S. Mislankar, A. G. Paul (1987). Coleus barbatus (C.forskohlii)(Lamiaceae) and the potential new drug forskolin (Coleonol). Economic Botany, 41, 474-483. Link: 10.1007/BF02908139
2. S. Bhaskar, Prof. Dr. Jitendra Malik (2023). A Comprehensive Study of the Coleus Forskohlii Plants Morphology, Phytochemistry, and Pharmacological Qualities. International Journal for Research in Applied Science and Engineering Technology, , . Link: 10.22214/ijraset.2023.48896
3. Coleus forskohlii (2006). Coleus forskohlii. Monograph.. Alternative medicine review : a journal of clinical therapeutic, 11 1,
   47-51 . Link:
4. Y. Miao, Q. H. Chen, K. Yu, Y. Wang, D. H. Liu (2021). First Report of Fusarium wilt of Coleus forskohlii Caused by Fusarium oxysporum in China.. Plant disease, , . Link: 10.1094/PDIS-11-20-2489-PDN
5. C. Kavitha, K. Rajamani, E. Vadivel (2010). Coleus forskohlii - a comprehensive review on morphology, phytochemistry and pharmacological aspects.. Journal of Medicinal Plants Research, 4, 278-285. Link:
6. A. Mastan, R. Bharadwaj, R. Kushwaha, C. S. Vivek Babu (2019). Functional Fungal Endophytes in Coleus forskohlii Regulate Labdane Diterpene Biosynthesis for Elevated Forskolin Accumulation in Roots. Microbial Ecology, 78, 914 - 926. Link: 10.1007/s00248-019-01376-w
7. B. Lokesh, R. Deepa, K. Divya (2018). Medicinal Coleus (Coleus forskohlii Briq): A phytochemical crop of commercial significance -Review. Journal of Pharmacognosy and Phytochemistry, 7, 2856-2864. Link:
8. B. Salehi, M. Staniak, K. Czopek, A. Stępień, K. Dua, Ridhima Wadhwa, D. Kumar Chellappan, O. Sytar, M. Brestič, Namrata Ganesh Bhat, Nanjangud Venkatesh Anil Kumar, María del Mar Contreras, F. Sharopov, William C. Cho, J. Sharifi‐Rad (2019). The Therapeutic Potential of the Labdane Diterpenoid Forskolin. Applied Sciences, , . Link: 10.3390/app9194089
9. Monisha Mitra, S. Gantait, N. Mandal (2020). Coleus forskohlii: advancements and prospects of in vitro biotechnology. Applied Microbiology and Biotechnology, 104, 2359 - 2371. Link: 10.1007/s00253-020-10377-6
10. Chaozhi Ma, L. Zou, Yu Xia, Yi-jun Tu, Daquan Xue, Yan-fang Yang, Dan Liu, Yanwen Liu, Hezhen Wu, Hanxiong Dan, Pengtao You (2018). Extracts of Coleus forskohlii relieves cough and asthma symptoms via modulating inflammation and the extracellular matrix. Journal of Cellular Biochemistry, 120, 9648 - 9655. Link: 10.1002/jcb.28243
11. J. Caprioli, M. Sears, L. Bausher, D. Gregory, A. Mead (1984). Forskolin lowers intraocular pressure by reducing aqueous inflow.. Investigative ophthalmology & visual science, 25 3,
    268-77 . Link:
12. M. G. Mutolo, G. Albanese, D. Rusciano, N. Pescosolido (2016). Oral Administration of Forskolin, Homotaurine, Carnosine, and Folic Acid in Patients with Primary Open Angle Glaucoma: Changes in Intraocular Pressure, Pattern Electroretinogram Amplitude, and Foveal Sensitivity.. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 32 3,
    178-83 . Link: 10.1089/jop.2015.0121
13. Vijay D. Wagh, K. V. Wagh, Prangya P Patil, M. Samanta (2008). Formulation and evaluation of opthalmic insert drug delivery system of forskolin. Asian Journal of Pharmaceutics, 2, 221. Link: 10.22377/AJP.V2I4.201
14. Shi Feng, Ling Wang, S. Voravuthikunchai, Zhang Liang, A. Liu, Fukai Bao (2016). Isoforskolin from Native Plant Coleus forskohlii of Yunnan, China Plays Multiple Biological Roles. Open Journal of Immunology, 06, 63-66. Link: 10.4236/OJI.2016.62006
15. N. Pescosolido, A. Librando (2010). Oral administration of an association of forskolin, rutin and vitamins B1 and B2 potentiates the hypotonising effects of pharmacological treatments in POAG patients.. La Clinica terapeutica, 161 3,
    e81-5 . Link:
16. R. Chakravarthy, S. CarolinePreethi, P. Durgadevi, Sadan, A. Am (2011). Invitro Studies in Coleus forskholii for Induction of ResistanceAgainst a Fungal Toxin Lasiodiplodia theobromae. Research and reviews in biosciences, 5, . Link:
17. Vijay D. Wagh, P. N. Patil, S. Surana, K. V. Wagh (2012). Forskolin: upcoming antiglaucoma molecule.. Journal of postgraduate medicine, 58 3,
    199-202 . Link: 10.4103/0022-3859.101396
18. M. P. Dubey, R. C. Srimal, S. Nityanand, Dhawan Bn (1981). Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohlii.. Journal of ethnopharmacology, 3 1,
    1-13 . Link: 10.1016/0378-8741(81)90010-6
19. A. Mastan, R. Bharadwaj, R. Kushwaha, C. S. Vivek Babu (2019). Functional Fungal Endophytes in Coleus forskohlii Regulate Labdane Diterpene Biosynthesis for Elevated Forskolin Accumulation in Roots. Microbial Ecology, 78, 914 - 926. Link: 10.1007/s00248-019-01376-w
20. Monisha Mitra, S. Gantait, N. Mandal (2020). Coleus forskohlii: advancements and prospects of in vitro biotechnology. Applied Microbiology and Biotechnology, 104, 2359 - 2371. Link: 10.1007/s00253-020-10377-6
21. M. Chakraborty, G. Kumar, R. Debnath, Kumar Rajib (2012). Forskolin - A Natural Root Extract of Coleus forskohlii. {"title"=>"", "scimago_quartile"=>nil}, , . Link: 10.31080/asps.2021.05.0751
22. V. Badmaev, Yoshitaka Hatakeyama, N. Yamazaki, A. Noro, F. Mohamed, Chi-Tang Ho, M. Pan (2015). Reprint of “Preclinical and clinical effects of Coleus forskohlii, Salacia reticulata and Sesamum indicum modifying pancreatic lipase inhibition in vitro and reducing total body fat”. Journal of Functional Foods, 18, 994-1001. Link: 10.1016/J.JFF.2015.05.027
23. S. Kamohara, S. Noparatanawong (2013). A Coleus forskohlii extract improves body composition in healthy volunteers: An open-label trial. Personalized Medicine Universe, 2, 25-27. Link: 10.1016/J.PMU.2013.04.003
24. Li-kun Han, C. Morimoto, R. Yu, H. Okuda (2005). Effects of Coleus forskohlii on fat storage in ovariectomized rats.. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 125 5,
    449-53 . Link: 10.1248/YAKUSHI.125.449
25. H. N. Shivaprasad, Sushma Gopalakrishna, Bhanumathy Mariyanna, Midhun Thekkoot, Roopa Reddy, B. Tippeswamy (2014). Effect of Coleus forskohlii extract on cafeteria diet-induced obesity in rats. Pharmacognosy Research, 6, 42 - 45. Link: 10.4103/0974-8490.122916
26. Y. Tung, Yi-Ang Shih, K. Nagabhushanam, Chi-Tang Ho, An-Chin Cheng, M. Pan (2021). Coleus forskohlii and Garcinia indica extracts attenuated lipid accumulation by regulating energy metabolism and modulating gut microbiota in obese mice.. Food research international, 142,
    110143 . Link: 10.1016/j.foodres.2021.110143
27. S. Kamohara (2016). An evidence-based review: Anti-obesity effects of Coleus forskohlii. Personalized Medicine Universe, 5, 16-20. Link: 10.1016/J.PMU.2016.02.001
28. Jing-Yi Chen, S. peng, Yeong-Hsiang Cheng, I-Ta Lee, Yu-Hsiang Yu (2021). Effect of Forskolin on Body Weight, Glucose Metabolism and Adipocyte Size of Diet-Induced Obesity in Mice. Animals : an Open Access Journal from MDPI, 11, . Link: 10.3390/ani11030645
29. S. Henderson, Bahrat Magu, C. Rasmussen, S. Lancaster, C. Kerksick, P. Smith, C. Melton, P. Cowan, M. Greenwood, C. Earnest, A. Almada, P. Milnor, T. Magrans, R. Bowden, S. Ounpraseuth, A. Thomas, R. Kreider (2005). Effects of Coleus Forskohlii Supplementation on Body Composition and Hematological Profiles in Mildly Overweight Women. Journal of the International Society of Sports Nutrition, 2, 54 - 62. Link: 10.1186/1550-2783-2-2-54
30. Hayley Loftus, Katie J. Astell, M. Mathai, X. Su (2015). Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. Nutrients, 7, 9508 - 9522. Link: 10.3390/nu7115483