Cocoa extract is a concentrated form derived from the seeds of the Theobroma cacao tree, commonly known as cocoa beans. This extract is rich in bioactive compounds, including flavanols, procyanidins, theobromine, and caffeine. These compounds are responsible for cocoa's characteristic bitter taste and chocolate flavor. The extract is obtained through various processes, including fermentation, drying, roasting, and grinding of cocoa beans, followed by extraction methods such as solvent extraction to concentrate the desired bioactive components.

The primary bioactive compounds in cocoa extract are flavanols, a group of polyphenolic compounds that include epicatechin and catechin. These flavanols are known for their potent antioxidant properties, which help neutralize free radicals and reduce oxidative stress in the body. Additionally, cocoa extract contains methylxanthines like theobromine and caffeine, which have stimulant effects and contribute to cognitive and cardiovascular benefits.

Cocoa extract is distinct from cocoa powder and chocolate in that it is specifically formulated to concentrate the beneficial compounds while minimizing sugars and fats. This makes it a popular ingredient in dietary supplements aimed at promoting cardiovascular health, cognitive function, and overall well-being. Given its rich profile of bioactive compounds, cocoa extract is often used in research studies to explore its potential health benefits and mechanisms of action.

Overall, cocoa extract offers a convenient and potent way to harness the health-promoting properties of cocoa beans, making it a valuable addition to various health and wellness regimens.

Cocoa extract is utilized for a wide range of health benefits, primarily due to its rich content of flavanols and other bioactive compounds. One of the most well-documented uses of cocoa extract is for cardiovascular health. Studies have shown that cocoa flavanols can improve blood flow, reduce blood pressure, and enhance endothelial function. For example, a study published in the "Journal of Hypertension" demonstrated that cocoa consumption dose-dependently improves flow-mediated dilation, decreases arterial stiffness, and lowers blood pressure, suggesting its potential role in cardiovascular prevention (Grassi et al., 2015).

In addition to cardiovascular benefits, cocoa extract has been studied for its cognitive and neuroprotective effects. Flavanols in cocoa are known to increase cerebral blood flow, which can enhance cognitive function and possibly reduce the risk of neurodegenerative diseases. A study in the "Journal of Cardiovascular Pharmacology" found that cocoa flavanols can acutely increase cerebral blood flow in healthy young adults, which may benefit cognitive performance (Dinges, 2006). Another study indicated that cocoa flavanols might improve cognitive function by increasing the bioavailability of nitric oxide, thereby promoting better blood flow to the brain.

Cocoa extract is also used for its antioxidant properties, which help combat oxidative stress and inflammation. These properties are beneficial not only for cardiovascular and cognitive health but also for skin health. Studies have shown that cocoa flavanols can improve skin elasticity, hydration, and density. For instance, research published in "The Journal of Nutrition" found that long-term ingestion of high-flavanol cocoa improved skin condition and provided photoprotection against UV-induced erythema (Heinrich et al., 2006).

Furthermore, cocoa extract has been explored for its potential benefits in metabolic health, particularly in improving insulin sensitivity and glycemic control. Research indicates that cocoa flavanols can modulate glucose metabolism and improve insulin signaling. A study in "The Journal of Nutrition" reported that cocoa supplementation improved insulin sensitivity in glucose-intolerant, hypertensive subjects, suggesting its potential role in managing metabolic disorders (Grassi et al., 2008).

Overall, the extensive research on cocoa extract underscores its multifaceted health benefits, making it a valuable supplement for promoting cardiovascular, cognitive, skin, and metabolic health.

Cocoa extract works primarily through its rich content of bioactive compounds, especially flavanols, procyanidins, theobromine, and caffeine. These compounds exert various physiological effects that contribute to its health benefits.

One of the primary mechanisms of action of cocoa flavanols is their ability to enhance endothelial function. Flavanols stimulate the production of nitric oxide (NO) in the endothelium, the inner lining of blood vessels. Nitric oxide is a potent vasodilator, meaning it helps relax and widen blood vessels, improving blood flow and reducing blood pressure. This mechanism was highlighted in a study published in the "Journal of Hypertension," which found that cocoa consumption improved flow-mediated dilation and decreased arterial stiffness, both of which are indicative of better vascular function (Grassi et al., 2015).

Cocoa extract also exerts significant antioxidant effects. The flavanols and procyanidins in cocoa are powerful antioxidants that neutralize free radicals and reduce oxidative stress. This antioxidant activity helps protect cells from damage and supports overall cellular health. The reduction in oxidative stress is particularly beneficial for cardiovascular health, as it prevents the oxidation of low-density lipoprotein (LDL) cholesterol, a key step in the development of atherosclerosis. A study in "The Journal of Nutrition" reported that cocoa products decrease LDL oxidizability, contributing to heart health (Mathur et al., 2002).

In terms of cognitive function, cocoa flavanols enhance cerebral blood flow, which can improve brain function and potentially reduce the risk of cognitive decline. The increased blood flow delivers more oxygen and nutrients to the brain, supporting neuronal health and function. Research published in the "Journal of Cardiovascular Pharmacology" demonstrated that cocoa flavanols could acutely increase cerebral blood flow in healthy young adults, suggesting benefits for cognitive performance (Dinges, 2006).

Cocoa extract also influences metabolic health by improving insulin sensitivity and modulating glucose metabolism. Flavanols in cocoa enhance the signaling pathways involved in glucose uptake and insulin sensitivity. They activate key proteins such as the insulin receptor, phosphoinositide 3-kinase (PI3K), and protein kinase B (AKT), which play crucial roles in the cellular response to insulin. A study in "Molecular Nutrition & Food Research" found that cocoa flavonoids improved insulin signaling and regulated glucose production in liver cells, highlighting their potential in managing metabolic disorders (Cordero-Herrera et al., 2013).

Overall, the bioactive compounds in cocoa extract work through multiple pathways to exert their beneficial effects on cardiovascular, cognitive, metabolic, and overall health. These mechanisms underscore the therapeutic potential of cocoa extract in various health applications.

Cocoa extract offers health benefits for both men and women, but certain applications may differ based on gender-specific health concerns and physiological differences.

For men, cocoa extract is often highlighted for its cardiovascular and cognitive benefits. Men are generally at a higher risk for cardiovascular diseases at a younger age compared to women, making the heart-healthy properties of cocoa extract particularly relevant. The flavanols in cocoa extract help improve endothelial function, reduce blood pressure, and enhance blood flow—all of which are crucial for cardiovascular health. A study published in the "Journal of Hypertension" found that cocoa consumption dose-dependently improved flow-mediated dilation and decreased arterial stiffness, both of which are important markers for cardiovascular health (Grassi et al., 2015).

In terms of cognitive health, men may benefit from the neuroprotective effects of cocoa flavanols, which improve cerebral blood flow and cognitive function. This can be particularly beneficial in reducing the risk of cognitive decline and neurodegenerative diseases, which are significant health concerns for aging men. A study in the "Journal of Cardiovascular Pharmacology" demonstrated that cocoa flavanols could acutely increase cerebral blood flow in healthy young adults, suggesting potential cognitive benefits (Dinges, 2006).

For women, cocoa extract is often utilized for its skin health benefits and its role in mitigating the effects of aging. Women are generally more concerned with skin health and appearance, and the antioxidant properties of cocoa flavanols can improve skin elasticity, hydration, and density. A study in "The Journal of Nutrition" reported that long-term ingestion of high-flavanol cocoa improved skin condition and provided photoprotection against UV-induced erythema (Heinrich et al., 2006). Additionally, another study found that regular cocoa flavanol consumption had positive effects on facial wrinkles and elasticity in moderately photo-aged women (Yoon et al., 2016).

Another area where cocoa extract can be particularly beneficial for women is in metabolic health. Women, especially those in post-menopausal stages, are at a higher risk for metabolic disorders such as insulin resistance and type 2 diabetes. Cocoa flavanols have been shown to improve insulin sensitivity and regulate glucose metabolism. Research published in "The Journal of Nutrition" indicated that cocoa supplementation improved insulin sensitivity in glucose-intolerant, hypertensive subjects, suggesting its potential role in managing metabolic disorders (Grassi et al., 2008).

While both men and women can benefit from the cardiovascular, cognitive, and metabolic health benefits of cocoa extract, women may find additional advantages in its skin health properties and its role in managing age-related metabolic changes. These gender-specific applications highlight the versatility of cocoa extract in promoting overall health and well-being.

The optimal dosage of cocoa extract can vary depending on the specific health benefits you are seeking, as well as individual factors such as age, weight, and overall health status. However, research studies provide some guidance on effective dosages for various health outcomes.

For cardiovascular health, studies have typically used doses ranging from 200 mg to 900 mg of cocoa flavanols per day. For example, a study published in the "Journal of Hypertension" found that daily doses of 80 mg to 800 mg of cocoa flavanols significantly improved flow-mediated dilation and decreased arterial stiffness (Grassi et al., 2015). Similarly, another study indicated that a daily intake of 500 mg of flavanols improved endothelial function and reduced blood pressure in hypertensive individuals (Grassi et al., 2008).

For cognitive benefits, similar dosages have been reported. A study in the "Journal of Cardiovascular Pharmacology" demonstrated that an acute dose of 790 mg of cocoa flavanols increased cerebral blood flow in healthy young adults, suggesting cognitive benefits (Dinges, 2006). Another study found that a daily intake of 500 mg of flavanols improved cognitive function in older adults (Desideri et al., 2012).

When it comes to skin health, research suggests that lower doses can also be effective. A study published in "The Journal of Nutrition" reported that daily consumption of 320 mg of cocoa flavanols over 24 weeks improved skin elasticity and reduced the appearance of wrinkles in moderately photo-aged women (Yoon et al., 2016). Another study found that 326 mg of cocoa flavanols per day provided photoprotection and improved skin condition over a 12-week period (Heinrich et al., 2006).

For general antioxidant and anti-inflammatory benefits, doses as low as 200 mg per day have been shown to be effective in reducing oxidative stress and inflammation markers. However, it's important to note that the optimal dosage may vary based on individual needs and health conditions.

As with any supplement, it's essential to start with a lower dose to assess tolerance and gradually increase it as needed. It's also advisable to consult with a healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or are taking other medications, to ensure that cocoa extract is appropriate for your specific needs.

In summary, effective dosages of cocoa extract typically range from 200 mg to 800 mg of cocoa flavanols per day, depending on the desired health benefits. Always consult with a healthcare professional to determine the best dosage for your individual circumstances.

Cocoa extract is generally well-tolerated by most individuals, but like any supplement, it can cause side effects in some people. The side effects are usually mild and may include gastrointestinal issues, nervous system stimulation, and allergic reactions.

One of the most common side effects of cocoa extract is gastrointestinal discomfort. This can include symptoms such as stomach cramps, nausea, bloating, and diarrhea. These symptoms are typically more likely to occur at higher doses. If you experience any gastrointestinal discomfort, it is advisable to reduce the dosage or discontinue use until the symptoms resolve.

Theobromine and caffeine, two of the primary methylxanthines found in cocoa extract, can cause nervous system stimulation. This may result in side effects such as increased heart rate, jitteriness, insomnia, and anxiety. People who are sensitive to stimulants or those who consume other sources of caffeine (such as coffee, tea, or energy drinks) should be cautious when taking cocoa extract to avoid excessive stimulant intake.

Allergic reactions to cocoa extract, although rare, can occur. Symptoms of an allergic reaction may include itching, rash, hives, and in severe cases, difficulty breathing or anaphylaxis. If you experience any signs of an allergic reaction, it is important to discontinue use immediately and seek medical attention.

In addition to these common side effects, there are some specific considerations for certain populations. For example, individuals with gastroesophageal reflux disease (GERD) or peptic ulcers may find that cocoa extract exacerbates their symptoms due to its potential to relax the lower esophageal sphincter and increase stomach acid production. Moreover, because cocoa extract can lower blood pressure, individuals with low blood pressure (hypotension) should use it with caution and under medical supervision.

Overall, while cocoa extract is generally safe for most people, it is essential to be aware of these potential side effects and to monitor for any adverse reactions. Starting with a lower dose and gradually increasing it can help minimize the risk of side effects. As always, it is advisable to consult with a healthcare provider before starting any new supplement, particularly if you have underlying health conditions or are taking other medications.

While cocoa extract is generally safe for most people, certain individuals should exercise caution or avoid it altogether due to specific health concerns or conditions. Here are some groups of people who should consider avoiding cocoa extract or consult with a healthcare provider before using it:

1. Individuals with Allergies: People who are allergic to cocoa or chocolate should avoid cocoa extract to prevent allergic reactions. Symptoms of an allergic reaction can include itching, rash, hives, and in severe cases, difficulty breathing or anaphylaxis.
2. People Sensitive to Stimulants: Cocoa extract contains theobromine and caffeine, which are stimulants. Individuals who are sensitive to these compounds may experience side effects such as increased heart rate, jitteriness, insomnia, and anxiety. Those who consume other sources of caffeine, like coffee or energy drinks, should also be cautious to avoid excessive stimulant intake.
3. Pregnant and Nursing Women: While moderate consumption of cocoa products is generally considered safe during pregnancy and breastfeeding, high doses of cocoa extract may not be advisable. The high levels of caffeine and theobromine in cocoa extract could potentially affect the fetus or nursing infant. It is best for pregnant and nursing women to consult with their healthcare provider before taking cocoa extract.
4. Individuals with Gastrointestinal Disorders: People with gastrointestinal conditions such as gastroesophageal reflux disease (GERD) or peptic ulcers may find that cocoa extract exacerbates their symptoms. Cocoa can relax the lower esophageal sphincter and increase stomach acid production, potentially worsening these conditions.
5. People with Heart Conditions: While cocoa extract has cardiovascular benefits, its stimulant properties can increase heart rate and blood pressure in some individuals. Those with pre-existing heart conditions, such as arrhythmias or hypertension, should consult with their healthcare provider before using cocoa extract to ensure it is safe for them.
6. Individuals with Low Blood Pressure (Hypotension): Cocoa extract can lower blood pressure due to its vasodilatory effects. People with low blood pressure should use cocoa extract with caution and under medical supervision to avoid potential complications such as dizziness or fainting.
7. People Taking Medications: Cocoa extract can interact with certain medications, including blood pressure medications, blood thinners, and stimulants. These interactions can either potentiate or diminish the effects of the medications. It is crucial for individuals taking any prescription or over-the-counter medications to consult with their healthcare provider before starting cocoa extract to avoid potential interactions.

In summary, while cocoa extract offers numerous health benefits, certain individuals should avoid it or seek medical advice before use. This includes people with allergies, those sensitive to stimulants, pregnant and nursing women, individuals with gastrointestinal disorders, heart conditions, low blood pressure, and those taking specific medications. Consulting with a healthcare provider can help determine if cocoa extract is appropriate for your individual health needs.

Yes, cocoa extract supplements can interact with certain medications, potentially affecting their efficacy or leading to adverse effects. It is important to be aware of these potential interactions and consult with a healthcare provider before starting cocoa extract, especially if you are taking any prescription or over-the-counter medications. Here are some notable interactions:

1. Blood Pressure Medications: Cocoa extract contains flavanols that can lower blood pressure by promoting vasodilation through increased nitric oxide production. While this can be beneficial for individuals with hypertension, it can also potentiate the effects of blood pressure medications, leading to hypotension (low blood pressure). Medications in this category include ACE inhibitors, beta-blockers, calcium channel blockers, and diuretics.
2. Blood Thinners and Anticoagulants: Cocoa extract has antiplatelet effects, which means it can inhibit platelet aggregation and reduce the risk of blood clots. However, this can enhance the effects of blood-thinning medications such as warfarin, aspirin, and clopidogrel, increasing the risk of bleeding and bruising. Monitoring by a healthcare provider is essential to adjust dosages if necessary.
3. Stimulants: Cocoa extract contains theobromine and caffeine, both of which are stimulants. Taking cocoa extract alongside other stimulant medications, such as those used for attention deficit hyperactivity disorder (ADHD) (e.g., amphetamines) or certain weight loss drugs, can amplify stimulant effects, leading to increased heart rate, jitteriness, and anxiety.
4. Diabetes Medications: Some studies suggest that cocoa flavanols can improve insulin sensitivity and help regulate blood sugar levels. While this can be beneficial, it can also enhance the effects of diabetes medications like insulin or oral hypoglycemic agents, potentially leading to hypoglycemia (low blood sugar). Blood glucose levels should be closely monitored, and medication dosages may need adjustment.
5. Antidepressants: Cocoa extract can interact with certain types of antidepressants, particularly monoamine oxidase inhibitors (MAOIs). MAOIs, such as phenelzine and tranylcypromine, can interact with foods high in tyramine, including cocoa products, potentially leading to hypertensive crises. Although cocoa is not particularly high in tyramine, caution is advised when combining it with MAOIs.
6. Anti-Anxiety Medications: Cocoa extract's stimulant properties may counteract the effects of anti-anxiety medications, such as benzodiazepines or beta-blockers prescribed for anxiety. This interaction can reduce the efficacy of these medications in managing symptoms of anxiety.

Given these potential interactions, it is crucial to consult with a healthcare provider before incorporating cocoa extract into your supplement regimen, especially if you are taking any of the mentioned medications. Your healthcare provider can help determine the appropriate dosage and monitor for any adverse effects or interactions, ensuring the safe and effective use of cocoa extract in conjunction with your current medications.

When looking for the best sources of cocoa extract, it's essential to consider several factors, including the concentration of bioactive compounds, the purity of the product, and the reputation of the manufacturer. Here are some key considerations and recommendations for finding high-quality cocoa extract:

1. Standardized Extracts: The best sources of cocoa extract are those that are standardized to contain a specific percentage of flavanols, the primary bioactive compounds responsible for many of the health benefits. Look for products that specify the amount of flavanols, such as "standardized to 20% flavanols" or similar indications on the label. This ensures you are getting a consistent and potent product.
2. Reputable Brands: Choose cocoa extract supplements from reputable brands with a history of quality and transparency. Brands that conduct third-party testing and provide certificates of analysis (CoA) are more likely to offer high-quality products. Some well-known supplement brands that offer cocoa extract include NOW Foods, Life Extension, and Nature's Way.
3. Organic and Non-GMO: Opt for cocoa extract products that are organic and non-GMO to ensure the highest purity and avoid potential contaminants like pesticides and genetically modified organisms. Organic certification also indicates that the cocoa beans were grown without synthetic fertilizers or harmful chemicals.
4. Minimal Additives: The best cocoa extract supplements contain minimal additives and fillers. Check the ingredient list to ensure the product is free from unnecessary additives, artificial colors, flavors, and preservatives. Pure cocoa extract with a simple ingredient list is preferable.
5. Forms of Cocoa Extract: Cocoa extract is available in various forms, including capsules, tablets, powders, and liquid extracts. Choose a form that suits your preference and lifestyle. For instance, capsules and tablets offer convenience and precise dosing, while powders can be easily mixed into beverages or smoothies.
6. Sustainability and Ethical Sourcing: Consider the sustainability and ethical sourcing practices of the brand. Brands that source their cocoa beans from fair-trade certified farms ensure that farmers are paid fairly and that ethical labor practices are followed. This not only supports sustainable agriculture but also promotes social responsibility.
7. Positive Reviews and Testimonials: Look for products with positive reviews and testimonials from other users. Customer feedback can provide insights into the effectiveness and quality of the product. However, it's essential to consider reviews from multiple sources to get a well-rounded perspective.

In summary, the best sources of cocoa extract are those that are standardized for flavanol content, offered by reputable and transparent brands, organic and non-GMO, free from unnecessary additives, available in various forms, and sourced sustainably and ethically. By considering these factors, you can ensure that you are getting a high-quality cocoa extract supplement that provides the desired health benefits.

Cocoa extract is available in various forms, each offering unique advantages depending on your preferences and needs. Here are the most common forms of cocoa extract:

1. Capsules and Tablets: These are among the most convenient forms of cocoa extract. Capsules and tablets provide a precise dosage, making it easy to monitor and control your intake. They are also portable, allowing you to take your supplement on the go without any hassle. Capsules and tablets are ideal for those who prefer a quick and easy way to incorporate cocoa extract into their daily routine.
2. Powders: Cocoa extract powder is another popular form, offering versatility in how it can be consumed. The powder can be easily mixed into beverages such as smoothies, protein shakes, or even coffee and tea. It can also be added to recipes, including baked goods, oatmeal, and yogurt. This form is particularly appealing for those who enjoy experimenting with different ways to include cocoa extract in their diet. Additionally, powders often have fewer additives and fillers compared to capsules and tablets.
3. Liquid Extracts and Tinctures: Liquid extracts and tinctures provide a highly concentrated form of cocoa extract. These are typically administered using a dropper, allowing for flexible dosing. Liquid extracts can be taken directly under the tongue for rapid absorption or mixed into beverages. This form is beneficial for those who may have difficulty swallowing capsules or tablets.
4. Softgels: Softgels are similar to capsules but are typically made with a gelatin-based shell, which can be easier to swallow for some people. They contain a liquid form of cocoa extract and offer the same convenience and precise dosing as capsules and tablets.
5. Chewables and Gummies: Chewable tablets and gummies are an increasingly popular form of cocoa extract, especially for those who prefer a more palatable and enjoyable way to take their supplements. These are often flavored and can be a good option for individuals who dislike swallowing pills. However, it's essential to check the ingredient list for added sugars and other additives.
6. Functional Foods and Beverages: Some functional foods and beverages are fortified with cocoa extract. These can include chocolate bars, energy bars, and ready-to-drink beverages. While these products can be a tasty way to consume cocoa extract, it's important to be mindful of the overall nutritional content, including added sugars and fats.

Each form of cocoa extract has its own set of advantages, and the best choice depends on your personal preferences, lifestyle, and specific health goals. For precise dosing and convenience, capsules, tablets, and softgels are ideal. If you prefer flexibility and versatility, powders and liquid extracts offer more options for incorporating cocoa extract into your diet. Chewables and gummies provide an enjoyable alternative, while functional foods and beverages can be a tasty way to enjoy the benefits of cocoa extract.

The efficacy of cocoa extract is largely attributed to its rich content of bioactive compounds, particularly flavanols, procyanidins, theobromine, and caffeine. Each of these sub-compounds plays a crucial role in delivering the health benefits associated with cocoa extract.

1. Flavanols: Flavanols, including epicatechin and catechin, are the most well-studied bioactive compounds in cocoa extract. These polyphenolic compounds are known for their potent antioxidant properties, which help neutralize free radicals and reduce oxidative stress. Flavanols are responsible for many of the cardiovascular benefits of cocoa extract, such as improving endothelial function, enhancing nitric oxide production, and promoting vasodilation. Studies have shown that cocoa flavanols can lower blood pressure, improve blood flow, and reduce arterial stiffness (Grassi et al., 2015). Additionally, flavanols contribute to cognitive health by increasing cerebral blood flow and potentially improving cognitive function (Dinges, 2006).
2. Procyanidins: Procyanidins are oligomeric flavanols that also exhibit strong antioxidant and anti-inflammatory properties. They work synergistically with monomeric flavanols to enhance the overall antioxidant capacity of cocoa extract. Procyanidins have been shown to protect against lipid oxidation, which is beneficial for cardiovascular health. They also play a role in improving skin health by promoting dermal blood circulation and enhancing skin elasticity and hydration (Heinrich et al., 2006).
3. Theobromine: Theobromine is a methylxanthine compound structurally similar to caffeine but with milder stimulant effects. It contributes to the cardiovascular benefits of cocoa extract by promoting vasodilation and improving blood flow. Theobromine also has mild diuretic properties, which can help reduce fluid retention. Additionally, it has been shown to have mood-enhancing effects and may contribute to the cognitive benefits of cocoa extract.
4. Caffeine: Although present in smaller amounts compared to theobromine, caffeine is another important methylxanthine in cocoa extract. It acts as a central nervous system stimulant, enhancing alertness and cognitive function. Caffeine's presence in cocoa extract can contribute to improved mental performance and reduced mental fatigue.
5. Polyphenolic Acids: Cocoa extract also contains various polyphenolic acids, such as gallic acid and ferulic acid, which contribute to its antioxidant activity. These compounds further enhance the extract's ability to neutralize free radicals and protect against oxidative stress.
6. Magnesium: While not a polyphenol, magnesium is an essential mineral found in cocoa beans. It plays a vital role in muscle function, nerve function, and energy production. Magnesium in cocoa extract can contribute to overall health and well-being.

The combined action of these sub-compounds makes cocoa extract a potent health supplement with a wide range of benefits. Flavanols and procyanidins are particularly critical for their antioxidant and cardiovascular effects, while theobromine and caffeine contribute to cognitive and mood-enhancing properties. Polyphenolic acids and magnesium further support the extract's overall efficacy. When choosing a cocoa extract supplement, it's important to look for products that are standardized for high flavanol and procyanidin content to ensure maximum health benefits.

Cocoa extract is known by various names, abbreviations, and related terms that can sometimes cause confusion. Here is a comprehensive list of the different names and compounds associated with cocoa extract:

1. Common Names:
   • Cocoa extract
   • Cacao extract
   • Chocolate extract
2. Botanical and Scientific Names:
   • Theobroma cacao (the botanical name of the cocoa tree)
   • Theobroma cacao extract (scientific term often used in ingredient lists)
3. Abbreviations:
   • Cocoa ext.
   • Cacao ext.
   • Theobroma cacao ext.
4. Misspellings and Variants:
   • Coco extract
   • Cocao extract
   • Cacao extact
5. Chemical Compounds and Ingredients:
   • Flavanols (main bioactive compounds, including epicatechin and catechin)
   • Procyanidins (oligomeric flavanols)
   • Theobromine (a methylxanthine compound similar to caffeine)
   • Caffeine (another methylxanthine compound)
   • Polyphenolic acids (such as gallic acid and ferulic acid)
   • Magnesium (an essential mineral found in cocoa beans)
6. Related Terms:
   • Cocoa powder (a less concentrated form containing more fiber and fewer active compounds)
   • Dark chocolate extract (a term sometimes used interchangeably, though it may contain additional ingredients like sugar and fats)
   • Cocoa polyphenols (referring to the antioxidant compounds in cocoa)
   • Chocolate flavonoids (another term highlighting the flavonoid content in cocoa)

Understanding these various names and compounds can help you identify cocoa extract in different products and supplements, ensuring you select the right one for your needs. Whether listed as Theobroma cacao extract, cocoa polyphenols, or simply cocoa extract, the key is to look for standardized products that specify the concentration of active compounds like flavanols and procyanidins. This will help you get the most health benefits from your cocoa extract supplement.

When selecting a cocoa extract supplement, it's crucial to scrutinize the label to ensure you're getting a high-quality product. Here are the key factors to look for:

1. Standardized Flavanol Content: One of the most important indicators of a high-quality cocoa extract supplement is the standardization of flavanol content. Look for products that specify the amount of flavanols, such as "standardized to 20% flavanols" or a specific number of milligrams per serving. This ensures consistency and potency, as the flavanols are the primary bioactive compounds responsible for the health benefits of cocoa extract.
2. Third-Party Testing and Certification: Quality supplements often undergo third-party testing to verify their purity, potency, and safety. Look for labels that mention third-party certification or testing, which indicates that the product has been independently verified. Certifications from organizations like NSF International, USP (United States Pharmacopeia), or ConsumerLab can provide additional assurance of quality.
3. Ingredient List: Check the ingredient list for any unnecessary additives, fillers, or artificial ingredients. A high-quality cocoa extract supplement should have a simple ingredient list, with cocoa extract being the primary component. Avoid products with added sugars, artificial colors, flavors, or preservatives.
4. Organic and Non-GMO Certification: If possible, choose a cocoa extract supplement that is certified organic and non-GMO. Organic certification ensures that the cocoa beans were grown without synthetic pesticides, fertilizers, or genetically modified organisms. This contributes to both the purity of the product and environmental sustainability.
5. Dosage Information: The label should clearly state the dosage per serving, including the amount of cocoa extract and the specific concentration of flavanols. This information is essential for determining the appropriate dosage to achieve the desired health benefits.
6. Sourcing and Manufacturing Practices: Look for information about the sourcing and manufacturing practices of the product. Brands that source their cocoa beans from fair-trade certified farms or practice sustainable farming methods are preferable. Additionally, products manufactured in facilities that follow Good Manufacturing Practices (GMP) ensure higher quality and safety standards.
7. Expiry Date and Storage Instructions: Ensure that the supplement has a clearly marked expiry date to guarantee its potency and effectiveness. Proper storage instructions, such as keeping the product in a cool, dry place, should also be included to maintain its quality.
8. Allergen Information: Check for any allergen information, especially if you have specific allergies or dietary restrictions. Some cocoa extract supplements may be processed in facilities that handle common allergens like nuts, soy, or dairy, so it's important to be aware of this information.
9. Brand Reputation and Reviews: While not always available on the label, researching the brand's reputation and reading customer reviews can provide additional insights into the product's quality and efficacy. Look for brands with positive feedback and a history of producing high-quality supplements.

By paying attention to these factors on the label, you can ensure that you are choosing a high-quality cocoa extract supplement that delivers the health benefits you seek. Standardized flavanol content, third-party testing, minimal additives, organic certification, and clear dosage information are all critical indicators of a quality product.

The information provided on this website, including any text, images, or other material contained within, is for informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. This page was created by the SuppCo editiorial team, with AI summarization tools, including data from but not limited to following studies:

1. A. Tanghe, E. Heyman, E. Lespagnol, J. Stautemas, B. Celie, J. op ‘t Roodt, E. Rietzschel, Danusa Dias Soares, N. Hermans, E. Tuenter, S. Shadid, P. Calders (2021). Acute Effects of Cocoa Flavanols on Blood Pressure and Peripheral Vascular Reactivity in Type 2 Diabetes Mellitus and Essential Hypertension: A Protocol for an Acute, Randomized, Double-Blinded, Placebo-Controlled Cross-Over Trial. Frontiers in Cardiovascular Medicine, 8, . Link: 10.3389/fcvm.2021.602086
2. Valeria Ludovici, Jens Barthelmes, M. Nägele, F. Enseleit, C. Ferri, A. Flammer, F. Ruschitzka, I. Sudano (2017). Cocoa, Blood Pressure, and Vascular Function. Frontiers in Nutrition, 4, . Link: 10.3389/fnut.2017.00036
3. L. Hooper, C. Kay, A. Abdelhamid, P. Kroon, J. Cohn, E. Rimm, A. Cassidy (2012). Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials.. The American journal of clinical nutrition, 95 3,
   740-51 . Link: 10.3945/ajcn.111.023457
4. K. Ried, Peter Fakler, N. Stocks (2017). Effect of cocoa on blood pressure.. The Cochrane database of systematic reviews, 4,
   CD008893 . Link: 10.1002/14651858.CD008893.pub3
5. H. Farouque, M. Leung, S. Hope, M. Baldi, C. Schechter, James Cameron, I. Meredith (2006). Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: a randomized double-blind placebo-controlled study.. Clinical science, 111 1,
   71-80 . Link: 10.1042/CS20060048
6. D. Dinges (2006). Cocoa Flavanols, Cerebral Blood Flow, Cognition, and Health: Going Forward. Journal of Cardiovascular Pharmacology, 47, S223-S225. Link: 10.1097/00005344-200606001-00019
7. K. Monahan (2012). Effect of cocoa/chocolate ingestion on brachial artery flow-mediated dilation and its relevance to cardiovascular health and disease in humans.. Archives of biochemistry and biophysics, 527 2,
   90-4 . Link: 10.1016/j.abb.2012.02.021
8. M. Shrime, Scott R. Bauer, Anna McDonald, N. Chowdhury, C. Coltart, E. Ding (2011). Flavonoid-rich cocoa consumption affects multiple cardiovascular risk factors in a meta-analysis of short-term studies.. The Journal of nutrition, 141 11,
   1982-8 . Link: 10.3945/jn.111.145482
9. D. Grassi, G. Desideri, S. Necozione, C. Lippi, R. Casale, G. Properzi, J. Blumberg, C. Ferri (2008). Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate.. The Journal of nutrition, 138 9,
   1671-6 . Link: 10.1093/JN/138.9.1671
10. D. Grassi, G. Desideri, S. Necozione, P. di Giosia, R. Barnabei, L. Allegaert, H. Bernaert, C. Ferri (2015). Cocoa consumption dose-dependently improves flow-mediated dilation and arterial stiffness decreasing blood pressure in healthy individuals. Journal of Hypertension, 33, 294–303. Link: 10.1097/HJH.0000000000000412
11. I. Peluso, M. Palmery, M. Serafini (2015). Effect of cocoa products and flavanols on platelet aggregation in humans: a systematic review.. Food & function, 6 7,
    2128-34 . Link: 10.1039/c5fo00113g
12. K. Murphy, A. Chronopoulos, I. Singh, Ma Francis, H. Moriarty, M. Pike, A. Turner, N. Mann, A. Sinclair (2003). Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function.. The American journal of clinical nutrition, 77 6,
    1466-73 . Link: 10.1093/AJCN/77.6.1466
13. Soolin Kim, Sin-Hee Park, H. Lee, V. Schini-Kerth, O. Kwon, Ki-Won Lee, M. Oak (2017). Cacao Polyphenols Potentiate Anti-Platelet Effect of Endothelial Cells and Ameliorate Hypercoagulatory States Associated with Hypercholesterolemia.. Journal of nanoscience and nanotechnology, 17 4,
    2817-823 . Link: 10.1166/JNN.2017.13317
14. Andrew J. Innes, G. Kennedy, M. Mclaren, A. Bancroft, J. Belch (2003). Dark chocolate inhibits platelet aggregation in healthy volunteers. Platelets, 14, 325 - 327. Link: 10.1080/0953710031000123681
15. I. Singh, H. Quinn, M. Mok, R. Southgate, A. Turner, Duo Li, A. Sinclair, J. Hawley (2006). The effect of exercise and training status on platelet activation: Do cocoa polyphenols play a role?. Platelets, 17, 361 - 367. Link: 10.1080/09537100600746953
16. Banafsheh Jafari Azad, E. Daneshzad, A. Meysamie, F. Koohdani (2020). Chronic and acute effects of cocoa products intake on arterial stiffness and platelet count and function: A systematic review and dose-response Meta-analysis of randomized clinical trials. Critical Reviews in Food Science and Nutrition, 61, 357 - 379. Link: 10.1080/10408398.2020.1733484
17. L. Ostertag, P. Kroon, S. Wood, G. Horgan, E. Cienfuegos-Jovellanos, S. Saha, G. Duthie, B. de Roos (2013). Flavan-3-ol-enriched dark chocolate and white chocolate improve acute measures of platelet function in a gender-specific way--a randomized-controlled human intervention trial.. Molecular nutrition & food research, 57 2,
    191-202 . Link: 10.1002/mnfr.201200283
18. K. Zięba, M. Makarewicz-Wujec, M. Kozłowska-Wojciechowska (2019). Cardioprotective Mechanisms of Cocoa. Journal of the American College of Nutrition, 38, 564 - 575. Link: 10.1080/07315724.2018.1557087
19. R. Carnevale, L. Loffredo, P. Pignatelli, C. Nocella, S. Bartimoccia, S. Santo, F. Martino, Elisa Catasca, L. Perri, F. Violi (2012). Dark chocolate inhibits platelet isoprostanes via NOX2 down‐regulation in smokers. Journal of Thrombosis and Haemostasis, 10, . Link: 10.1111/j.1538-7836.2011.04558.x
20. D. Rein, T. Paglieroni, D. Pearson, Theodore Wun, H. Schmitz, R. Gosselin, C. Keen (2000). Cocoa and wine polyphenols modulate platelet activation and function.. The Journal of nutrition, 130 8S Suppl,
    2120S-6S . Link: 10.1093/jn/130.8.2120S
21. Yeyi Gu, W. Hurst, D. Stuart, J. Lambert (2011). Inhibition of key digestive enzymes by cocoa extracts and procyanidins.. Journal of agricultural and food chemistry, 59 10,
    5305-11 . Link: 10.1021/jf200180n
22. Isabel Cordero-Herrera, M. Martín, L. Goya, S. Ramos (2015). Cocoa flavonoids protect hepatic cells against high-glucose-induced oxidative stress: relevance of MAPKs.. Molecular nutrition & food research, 59 4,
    597-609 . Link: 10.1002/mnfr.201400492
23. I. Rodriguez-Ramiro, S. Ramos, L. Bravo, L. Goya, M. Martín (2011). Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway.. The Journal of nutritional biochemistry, 22 12,
    1186-94 . Link: 10.1016/j.jnutbio.2010.10.005
24. Dorota Żyżelewicz, Małgorzata Zakłos-Szyda, J. Juśkiewicz, Małgorzata Bojczuk, Joanna Oracz, G. Budryn, Karolina Miśkiewicz, W. Krysiak, Z. Zduńczyk, A. Jurgoński (2016). Cocoa bean (Theobroma cacao L.) phenolic extracts as PTP1B inhibitors, hepatic HepG2 and pancreatic β-TC3 cell cytoprotective agents and their influence on oxidative stress in rats. Food Research International, 89, 946-957. Link: 10.1016/J.FOODRES.2016.01.009
25. M. Rebollo-Hernanz, Y. Aguilera, M. Martín-Cabrejas, E. González de Mejía (2022). Phytochemicals from the Cocoa Shell Modulate Mitochondrial Function, Lipid and Glucose Metabolism in Hepatocytes via Activation of FGF21/ERK, AKT, and mTOR Pathways. Antioxidants, 11, . Link: 10.3390/antiox11010136
26. E. Ramiro, À. Franch, C. Castellote, F. Pérez-Cano, Joan Permanyer, M. Izquierdo-Pulido, M. Castell (2005). Flavonoids from Theobroma cacao down-regulate inflammatory mediators.. Journal of agricultural and food chemistry, 53 22,
    8506-11 . Link: 10.1021/JF0511042
27. Isabel Cordero-Herrera, M. Martín, L. Goya, S. Ramos (2014). Cocoa flavonoids attenuate high glucose-induced insulin signalling blockade and modulate glucose uptake and production in human HepG2 cells.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 64,
    10-9 . Link: 10.1016/j.fct.2013.11.014
28. Isabel Cordero-Herrera, M. Martín, L. Bravo, L. Goya, S. Ramos (2013). Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells.. Molecular nutrition & food research, 57 6,
    974-85 . Link: 10.1002/mnfr.201200500
29. A. Jalil, A. Ismail, C. Pei, M. Hamid, S. Kamaruddin (2008). Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obese-diabetic (Ob-db) rats.. Journal of agricultural and food chemistry, 56 17,
    7877-84 . Link: 10.1021/jf8015915
30. M. Martín, S. Ramos, R. Mateos, Ana Belén Granado Serrano, M. Izquierdo-Pulido, L. Bravo, L. Goya (2008). Protection of human HepG2 cells against oxidative stress by cocoa phenolic extract.. Journal of agricultural and food chemistry, 56 17,
    7765-72 . Link: 10.1021/jf801744r
31. Luis Jorge Coronado-Cáceres, B. Hernández-Ledesma, L. Mojica, L. Quevedo-Corona, Griselda Rabadán-Chávez, G. Castillo-Herrera, Eugenia Lugo Cervantes (2021). Cocoa (Theobroma cacao L.) Seed-Derived Peptides Reduce Blood Pressure by Interacting with the Catalytic Site of the Angiotensin-Converting Enzyme. Foods, 10, . Link: 10.3390/foods10102340
32. C. Ferri, G. Desideri, L. Ferri, Ilenia Proietti, Stefania Di Agostino, Letizia Martella, Francesca Mai, P. di Giosia, D. Grassi (2015). Cocoa, blood pressure, and cardiovascular health.. Journal of agricultural and food chemistry, 63 45,
    9901-9 . Link: 10.1021/acs.jafc.5b01064
33. D. Grassi, G. Desideri, S. Necozione, P. di Giosia, R. Barnabei, L. Allegaert, H. Bernaert, C. Ferri (2015). Cocoa consumption dose-dependently improves flow-mediated dilation and arterial stiffness decreasing blood pressure in healthy individuals. Journal of Hypertension, 33, 294–303. Link: 10.1097/HJH.0000000000000412
34. Valeria Ludovici, Jens Barthelmes, M. Nägele, F. Enseleit, C. Ferri, A. Flammer, F. Ruschitzka, I. Sudano (2017). Cocoa, Blood Pressure, and Vascular Function. Frontiers in Nutrition, 4, . Link: 10.3389/fnut.2017.00036
35. S. Desch, Johanna Schmidt, D. Kobler, M. Sonnabend, I. Eitel, M. Sareban, K. Rahimi, G. Schuler, H. Thiele (2010). Effect of cocoa products on blood pressure: systematic review and meta-analysis.. American journal of hypertension, 23 1,
    97-103 . Link: 10.1038/ajh.2009.213
36. S. Jafarnejad, Mina Salek, Cain C. T. Clark (2020). Cocoa Consumption and Blood Pressure in Middle-Aged and Elderly Subjects: a Meta-Analysis. Current Hypertension Reports, 22, 1-15. Link: 10.1007/s11906-019-1005-0
37. D. Grassi, S. Necozione, C. Lippi, G. Croce, Letizia Valeri, P. Pasqualetti, G. Desideri, J. Blumberg, C. Ferri (2005). Cocoa Reduces Blood Pressure and Insulin Resistance and Improves Endothelium-Dependent Vasodilation in Hypertensives. Hypertension, 46, 398-405. Link: 10.1161/01.HYP.0000174990.46027.70
38. K. Ried, T. Sullivan, Peter Fakler, O. Frank, N. Stocks (2010). Does chocolate reduce blood pressure? A meta-analysis. BMC Medicine, 8, 39 - 39. Link: 10.1186/1741-7015-8-39
39. K. Ried, T. Sullivan, Peter Fakler, O. Frank, N. Stocks (2012). Effect of cocoa on blood pressure.. The Cochrane database of systematic reviews, 8,
    CD008893 . Link: 10.1002/14651858.CD008893.pub2
40. K. Ried, Peter Fakler, N. Stocks (2017). Effect of cocoa on blood pressure.. The Cochrane database of systematic reviews, 4,
    CD008893 . Link: 10.1002/14651858.CD008893.pub3
41. Massaro Marika, E. Scoditti, M. Carluccio, Antonia Kaltsatou, A. Cicchella (2019). Effect of Cocoa Products and Its Polyphenolic Constituents on Exercise Performance and Exercise-Induced Muscle Damage and Inflammation: A Review of Clinical Trials. Nutrients, 11, . Link: 10.3390/nu11071471
42. Patricia Ruiz-Iglesias, M. Massot-Cladera, M. J. Rodríguez-Lagunas, À. Franch, Mariona Camps-Bossacoma, F. Pérez-Cano, M. Castell (2022). Protective Effect of a Cocoa-Enriched Diet on Oxidative Stress Induced by Intensive Acute Exercise in Rats. Antioxidants, 11, . Link: 10.3390/antiox11040753
43. Griselda Rabadán-Chávez, L. Quevedo-Corona, Angel Miliar García, E. Reyes-Maldonado, M. Jaramillo-Flores (2016). Cocoa powder, cocoa extract and epicatechin attenuate hypercaloric diet-induced obesity through enhanced β-oxidation and energy expenditure in white adipose tissue. Journal of Functional Foods, 20, 54-67. Link: 10.1016/J.JFF.2015.10.016
44. F. G. de Carvalho, M. Fisher, Todd T. Thornley, K. Roemer, Robert Pritchett, E. Freitas, K. Pritchett (2019). Cocoa flavanol effects on markers of oxidative stress and recovery after muscle damage protocol in elite rugby players.. Nutrition, 62,
    47-51 . Link: 10.1016/j.nut.2018.10.035
45. J. Allgrove, Emily Farrell, M. Gleeson, G. Williamson, K. Cooper (2011). Regular dark chocolate consumption's reduction of oxidative stress and increase of free-fatty-acid mobilization in response to prolonged cycling.. International journal of sport nutrition and exercise metabolism, 21 2,
    113-23 . Link: 10.1123/IJSNEM.21.2.113
46. P. Taub, I. Ramírez‐Sánchez, Minal R. Patel, E. Higginbotham, Aldo Moreno-Ulloa, L. M. Román-Pintos, P. Phillips, G. Perkins, G. Ceballos, F. Villarreal (2016). Beneficial effects of dark chocolate on exercise capacity in sedentary subjects: underlying mechanisms. A double blind, randomized, placebo controlled trial.. Food & function, 7 9,
    3686-93 . Link: 10.1039/c6fo00611f
47. Jose Ángel García-Merino, Beatriz de Lucas, K. Herrera-Rocha, Diego Moreno-Pérez, Maria Gregoria Montalvo-Lominchar, A. Fernández-Romero, C. Santiago, M. Pérez-Ruiz, Mara Larrosa (2022). Flavanol-Rich Cocoa Supplementation Inhibits Mitochondrial Biogenesis Triggered by Exercise. Antioxidants, 11, . Link: 10.3390/antiox11081522
48. K. Davison, A. Coates, J. Buckley, P. Howe (2008). Effect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjects. International Journal of Obesity, 32, 1289-1296. Link: 10.1038/ijo.2008.66
49. L. Decroix, C. Tonoli, E. Lespagnol, C. Balestra, Amandine Descat, M. Drittij-Reijnders, Jamie R. Blackwell, W. Stahl, A. Jones, Antje R. Weseler, A. Bast, R. Meeusen, E. Heyman (2018). One-week cocoa flavanol intake increases prefrontal cortex oxygenation at rest and during moderate-intensity exercise in normoxia and hypoxia.. Journal of applied physiology, 125 1,
    8-18 . Link: 10.1152/japplphysiol.00055.2018
50. E. Cavarretta, M. Peruzzi, R. Del Vescovo, Fabio Di Pilla, G. Gobbi, A. Serdoz, R. Ferrara, Leonardo Schirone, S. Sciarretta, C. Nocella, E. De Falco, Sonia Schiavon, G. Biondi‐Zoccai, G. Frati, R. Carnevale (2018). Dark Chocolate Intake Positively Modulates Redox Status and Markers of Muscular Damage in Elite Football Athletes: A Randomized Controlled Study. Oxidative Medicine and Cellular Longevity, 2018, . Link: 10.1155/2018/4061901
51. G. Schinella, S. Mosca, E. Cienfuegos-Jovellanos, M. A. Pasamar, B. Muguerza, D. Ramón, J. Ríos (2010). Antioxidant properties of polyphenol-rich cocoa products industrially processed. Food Research International, 43, 1614-1623. Link: 10.1016/J.FOODRES.2010.04.032
52. G. B. Teboukeu, F. T. Djikeng, M. Klang, S. Ndomou, M. Karuna, H. Womeni (2018). Polyphenol antioxidants from cocoa pods: Extraction optimization, effect of the optimized extract, and storage time on the stability of palm olein during thermoxidation. Journal of Food Processing and Preservation, 42, . Link: 10.1111/JFPP.13592
53. Willy Arnold Daniel Sekewael, E. Pudjihartati, Teguh Iman Santoso (2020). Effect of ascorbic acid on chemical content and viability of cocoa seed after storage. Pelita Perkebunan (a Coffee and Cocoa Research Journal), , . Link: 10.22302/iccri.jur.pelitaperkebunan.v35i2.354
54. Surekha Mathur, S. Devaraj, S. Grundy, I. Jialal (2002). Cocoa products decrease low density lipoprotein oxidative susceptibility but do not affect biomarkers of inflammation in humans.. The Journal of nutrition, 132 12,
    3663-7 . Link: 10.1093/JN/132.12.3663
55. O. Hassan, Lam Swet Fan (2005). The anti-oxidation potential of polyphenol extract from cocoa leaves on mechanically deboned chicken meat (MDCM). Lwt - Food Science and Technology, 38, 315-321. Link: 10.1016/J.LWT.2004.06.013
56. Said Toro-Uribe, L. López-Giraldo, E. Decker (2018). Relationship between the Physiochemical Properties of Cocoa Procyanidins and Their Ability to Inhibit Lipid Oxidation in Liposomes.. Journal of agricultural and food chemistry, 66 17,
    4490-4502 . Link: 10.1021/acs.jafc.8b01074
57. A. Jalil, A. Ismail, C. Pei, M. Hamid, S. Kamaruddin (2008). Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obese-diabetic (Ob-db) rats.. Journal of agricultural and food chemistry, 56 17,
    7877-84 . Link: 10.1021/jf8015915
58. Griselda Rabadán-Chávez, L. Quevedo-Corona, Angel Miliar García, E. Reyes-Maldonado, M. Jaramillo-Flores (2016). Cocoa powder, cocoa extract and epicatechin attenuate hypercaloric diet-induced obesity through enhanced β-oxidation and energy expenditure in white adipose tissue. Journal of Functional Foods, 20, 54-67. Link: 10.1016/J.JFF.2015.10.016
59. I. Ibero-Baraibar, Itziar Abete, S. Navas-Carretero, S. Navas-Carretero, A. Massis-Zaid, José Alfredo Martínez, José Alfredo Martínez, M. Zulet, M. Zulet (2014). Oxidised LDL levels decreases after the consumption of ready-to-eat meals supplemented with cocoa extract within a hypocaloric diet.. Nutrition, metabolism, and cardiovascular diseases : NMCD, 24 4,
    416-22 . Link: 10.1016/j.numecd.2013.09.017
60. M. Martín, S. Ramos, R. Mateos, Ana Belén Granado Serrano, M. Izquierdo-Pulido, L. Bravo, L. Goya (2008). Protection of human HepG2 cells against oxidative stress by cocoa phenolic extract.. Journal of agricultural and food chemistry, 56 17,
    7765-72 . Link: 10.1021/jf801744r
61. A. Jalil, A. Ismail, C. Pei, M. Hamid, S. Kamaruddin (2008). Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obese-diabetic (Ob-db) rats.. Journal of agricultural and food chemistry, 56 17,
    7877-84 . Link: 10.1021/jf8015915
62. A. Ruzaidi, I. Amin, A. G. Nawalyah, M. Hamid, H. Faiz-ul- (2005). The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats.. Journal of ethnopharmacology, 98 1-2,
    55-60 . Link: 10.1016/J.JEP.2004.12.018
63. A. Jalil, A. Ismail, P. Chong, M. Hamid, S. Kamaruddin (2009). Effects of cocoa extract containing polyphenols and methylxanthines on biochemical parameters of obese‐diabetic rats. Journal of the Science of Food and Agriculture, 89, 130-137. Link: 10.1002/JSFA.3419
64. Kathryn Racine, Lisard Iglesias-Carres, Lauren Essenmacher, G. Agnello, Jeffery S. Tessem, M. Ferruzzi, C. Kay, A. Neilson (2021). Evaluation of Poorly-Bioavailable Cocoa Flavanols and Their Gut Microbial Metabolites in Potentiating Anti-diabetic Activities Through BTBR.Cg-Lepob/ob/WiscJ Mice. Current Developments in Nutrition, , . Link: 10.1093/CDN/NZAB037_071
65. J. Konya, T. Sathyapalan, E. Kilpatrick, S. Atkin (2019). The Effects of Soy Protein and Cocoa With or Without Isoflavones on Glycemic Control in Type 2 Diabetes. A Double-Blind, Randomized, Placebo-Controlled Study. Frontiers in Endocrinology, 10, . Link: 10.3389/fendo.2019.00296
66. D. Mellor, T. Sathyapalan, E. Kilpatrick, S. Atkin (2015). Diabetes and chocolate: friend or foe?. Journal of agricultural and food chemistry, 63 45,
    9910-8 . Link: 10.1021/acs.jafc.5b00776
67. Mina Darand, Masoomeh Hajizadeh Oghaz, A. Hadi, Masoumeh Atefi, R. Amani (2021). The effect of cocoa/dark chocolate consumption on lipid profile, glycemia, and blood pressure in diabetic patients: A meta‐analysis of observational studies. Phytotherapy Research, 35, 5487 - 5501. Link: 10.1002/ptr.7183
68. Isabel Cordero-Herrera, M. Martín, L. Bravo, L. Goya, S. Ramos (2013). Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells.. Molecular nutrition & food research, 57 6,
    974-85 . Link: 10.1002/mnfr.201200500
69. Isabel Cordero-Herrera, M. Martín, F. Escrivá, C. Álvarez, L. Goya, S. Ramos (2015). Cocoa-rich diet ameliorates hepatic insulin resistance by modulating insulin signaling and glucose homeostasis in Zucker diabetic fatty rats.. The Journal of nutritional biochemistry, 26 7,
    704-12 . Link: 10.1016/j.jnutbio.2015.01.009
70. A. Basu, N. Betts, M. Leyva, Dongxu Fu, C. Aston, T. Lyons (2015). Acute Cocoa Supplementation Increases Postprandial HDL Cholesterol and Insulin in Obese Adults with Type 2 Diabetes after Consumption of a High-Fat Breakfast.. The Journal of nutrition, 145 10,
    2325-32 . Link: 10.3945/jn.115.215772
71. Isabel Cordero-Herrera, M. Martín, L. Goya, S. Ramos (2014). Cocoa flavonoids attenuate high glucose-induced insulin signalling blockade and modulate glucose uptake and production in human HepG2 cells.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 64,
    10-9 . Link: 10.1016/j.fct.2013.11.014
72. Isabel Cordero-Herrera, M. Martín, L. Bravo, L. Goya, S. Ramos (2013). Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells.. Molecular nutrition & food research, 57 6,
    974-85 . Link: 10.1002/mnfr.201200500
73. A. Basu, N. Betts, M. Leyva, Dongxu Fu, C. Aston, T. Lyons (2015). Acute Cocoa Supplementation Increases Postprandial HDL Cholesterol and Insulin in Obese Adults with Type 2 Diabetes after Consumption of a High-Fat Breakfast.. The Journal of nutrition, 145 10,
    2325-32 . Link: 10.3945/jn.115.215772
74. Isabel Cordero-Herrera, M. Martín, F. Escrivá, C. Álvarez, L. Goya, S. Ramos (2015). Cocoa-rich diet ameliorates hepatic insulin resistance by modulating insulin signaling and glucose homeostasis in Zucker diabetic fatty rats.. The Journal of nutritional biochemistry, 26 7,
    704-12 . Link: 10.1016/j.jnutbio.2015.01.009
75. M. Rebollo-Hernanz, Qiaozhi Zhang, Y. Aguilera, M. Martín-Cabrejas, E. D. de Mejia (2019). Cocoa Shell Aqueous Phenolic Extract Preserves Mitochondrial Function and Insulin Sensitivity by Attenuating Inflammation between Macrophages and Adipocytes In Vitro.. Molecular nutrition & food research, 63 10,
    e1801413 . Link: 10.1002/mnfr.201801413
76. A. Jalil, A. Ismail, C. Pei, M. Hamid, S. Kamaruddin (2008). Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obese-diabetic (Ob-db) rats.. Journal of agricultural and food chemistry, 56 17,
    7877-84 . Link: 10.1021/jf8015915
77. M. C. Castro, H. Villagarcía, A. Nazar, L. G. Arbeláez, M. L. Massa, H. D. Del Zotto, J. Ríos, G. Schinella, F. Francini (2020). Cacao extract enriched in polyphenols prevents endocrine-metabolic disturbances in a rat model of prediabetes triggered by a sucrose rich diet.. Journal of ethnopharmacology, ,
    112263 . Link: 10.1016/j.jep.2019.112263
78. D. Grassi, C. Lippi, S. Necozione, G. Desideri, C. Ferri (2005). Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons.. The American journal of clinical nutrition, 81 3,
    611-4 . Link: 10.1093/AJCN/81.3.611
79. Suzanne M. Bowser, Will Moore, R. McMillan, Melanie R Dorenkott, K. Goodrich, Liyun Ye, S. O'keefe, M. Hulver, A. Neilson (2017). High-molecular-weight cocoa procyanidins possess enhanced insulin-enhancing and insulin mimetic activities in human primary skeletal muscle cells compared to smaller procyanidins.. The Journal of nutritional biochemistry, 39,
    48-58 . Link: 10.1016/j.jnutbio.2016.10.001
80. R. Muniyappa, Gail Hall, Terrie L Kolodziej, R. Karne, S. Crandon, M. Quon (2008). Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension.. The American journal of clinical nutrition, 88 6,
    1685-96 . Link: 10.3945/ajcn.2008.26457
81. I. Ibero-Baraibar, Itziar Abete, S. Navas-Carretero, S. Navas-Carretero, A. Massis-Zaid, José Alfredo Martínez, José Alfredo Martínez, M. Zulet, M. Zulet (2014). Oxidised LDL levels decreases after the consumption of ready-to-eat meals supplemented with cocoa extract within a hypocaloric diet.. Nutrition, metabolism, and cardiovascular diseases : NMCD, 24 4,
    416-22 . Link: 10.1016/j.numecd.2013.09.017
82. S. Davinelli, G. Corbi, A. Zarrelli, M. Arisi, P. Calzavara-Pinton, D. Grassi, I. De Vivo, G. Scapagnini (2018). Short-term supplementation with flavanol-rich cocoa improves lipid profile, antioxidant status and positively influences the AA/EPA ratio in healthy subjects.. The Journal of nutritional biochemistry, 61,
    33-39 . Link: 10.1016/j.jnutbio.2018.07.011
83. T. Kurosawa, Fumi Itoh, Aiko Nozaki, Y. Nakano, S. Katsuda, N. Osakabe, H. Tsubone, K. Kondo, H. Itakura (2005). Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits.. Atherosclerosis, 179 2,
    237-46 . Link: 10.1016/J.ATHEROSCLEROSIS.2004.12.003
84. Surekha Mathur, S. Devaraj, S. Grundy, I. Jialal (2002). Cocoa products decrease low density lipoprotein oxidative susceptibility but do not affect biomarkers of inflammation in humans.. The Journal of nutrition, 132 12,
    3663-7 . Link: 10.1093/JN/132.12.3663
85. S. Baba, N. Osakabe, Y. Kato, M. Natsume, A. Yasuda, T. Kido, Kumiko Fukuda, Y. Muto, K. Kondo (2007). Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans.. The American journal of clinical nutrition, 85 3,
    709-17 . Link: 10.1093/AJCN/85.3.709
86. A. Yasuda, M. Natsume, N. Osakabe, Keiko Kawahata, J. Koga (2011). Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells.. Journal of agricultural and food chemistry, 59 4,
    1470-6 . Link: 10.1021/jf103820b
87. N. Osakabe, S. Baba, A. Yasuda, T. Iwamoto, M. Kamiyama, T. Tokunaga, K. Kondo (2004). Dose-Response Study of Daily Cocoa Intake on the Oxidative Susceptibility of Low-Density Lipoprotein in Healthy Human Volunteers. Journal of Health Science, 50, 679-684. Link: 10.1248/JHS.50.679
88. O. Tokede, J. Gaziano, J. Gaziano, L. Djoussé, L. Djoussé (2011). Effects of cocoa products/dark chocolate on serum lipids: a meta-analysis. European Journal of Clinical Nutrition, 65, 879-886. Link: 10.1038/ejcn.2011.64
89. Nasiruddin Khan, M. Monagas, M. Monagas, C. Andrés-Lacueva, R. Casas, M. Urpi-Sardà, R. Lamuela-Raventós, R. Lamuela-Raventós, R. Estruch, R. Estruch (2012). Regular consumption of cocoa powder with milk increases HDL cholesterol and reduces oxidized LDL levels in subjects at high-risk of cardiovascular disease.. Nutrition, metabolism, and cardiovascular diseases : NMCD, 22 12,
    1046-53 . Link: 10.1016/j.numecd.2011.02.001
90. S. Baba, M. Natsume, A. Yasuda, Yuko Nakamura, Takaaki Tamura, N. Osakabe, M. Kanegae, K. Kondo (2007). Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder.. The Journal of nutrition, 137 6,
    1436-41 . Link: 10.1093/JN/137.6.1436
91. Kazuyuki Ono, Toshio Takahashi, M. Kamei, T. Mato, S. Hashizume, S. Kamiya, H. Tsutsumi (2003). Effects of an aqueous extract of cocoa on nitric oxide production of macrophages activated by lipopolysaccharide and interferon-gamma.. Nutrition, 19 7-8,
    681-5 . Link:
92. C. Fraga, M. C. Litterio, P. Prince, Valeria Calabró, Bárbara Piotrkowski, M. Galleano (2010). Cocoa flavanols: effects on vascular nitric oxide and blood pressure. Journal of Clinical Biochemistry and Nutrition, 48, 63 - 67. Link: 10.3164/jcbn.11-010FR
93. D. Grassi, G. Desideri, S. Necozione, C. Lippi, R. Casale, G. Properzi, J. Blumberg, C. Ferri (2008). Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate.. The Journal of nutrition, 138 9,
    1671-6 . Link: 10.1093/JN/138.9.1671
94. H. Sies, T. Schewe, C. Heiss, M. Kelm (2005). Cocoa polyphenols and inflammatory mediators.. The American journal of clinical nutrition, 81 1 Suppl,
    304S-312S . Link: 10.1093/ajcn/81.1.304S
95. C. Heiss, P. Kleinbongard, A. Dejam, Sandra Perré, H. Schroeter, H. Sies, M. Kelm (2005). Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers.. Journal of the American College of Cardiology, 46 7,
    1276-83 . Link: 10.1016/J.JACC.2005.06.055
96. (2020). Cocoa Extract. Definitions, , . Link: 10.32388/howi71
97. Liberty Barokah, S. C. W. Baktiyani, U. Kalsum (2016). Protective effect of Theobroma cacao on nitric oxide and endothelin-1 level in endothelial cells induced by plasma from preeclamptic patients: In silico and in vitro studies☆. European Journal of Integrative Medicine, 8, 73-78. Link: 10.1016/J.EUJIM.2015.11.023
98. I. Persson, Karin Persson, S. Hägg, R. Andersson (2011). Effects of Cocoa Extract and Dark Chocolate on Angiotensin-converting Enzyme and Nitric Oxide in Human Endothelial Cells and Healthy Volunteers–A Nutrigenomics Perspective. Journal of Cardiovascular Pharmacology, 57, 44-50. Link: 10.1097/FJC.0b013e3181fe62e3
99. N. Fisher, M. Hughes, M. Gerhard-Herman, N. Hollenberg (2003). Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. Journal of Hypertension, 21, 2281-2286. Link: 10.1097/00004872-200312000-00016
100. Kazuyuki Ono, Toshio Takahashi, M. Kamei, T. Mato, S. Hashizume, S. Kamiya, H. Tsutsumi (2003). Effects of an aqueous extract of cocoa on nitric oxide production of macrophages activated by lipopolysaccharide and interferon-γ. Nutrition, 19, 681-685. Link: 10.1016/S0899-9007(03)00092-3
101. P. Calzavara-Pinton, I. Calzavara-Pinton, M. Arisi, M. Rossi, G. Scapagnini, S. Davinelli, M. Venturini (2019). Cutaneous Photoprotective Activity of a Short‐term Ingestion of High‐Flavanol Cocoa: A Nutritional Intervention Study. Photochemistry and Photobiology, 95, . Link: 10.1111/php.13087
102. M. Martín, S. Ramos, R. Mateos, Ana Belén Granado Serrano, M. Izquierdo-Pulido, L. Bravo, L. Goya (2008). Protection of human HepG2 cells against oxidative stress by cocoa phenolic extract.. Journal of agricultural and food chemistry, 56 17,
     7765-72 . Link: 10.1021/jf801744r
103. Vincenzo Vestuto, G. Amodio, G. Pepe, M. G. Basilicata, R. Belvedere, Enza Napolitano, D. Guarnieri, V. Pagliara, S. Paladino, M. Rodriquez, A. Bertamino, P. Campiglia, P. Remondelli, O. Moltedo (2022). Cocoa Extract Provides Protection against 6-OHDA Toxicity in SH-SY5Y Dopaminergic Neurons by Targeting PERK. Biomedicines, 10, . Link: 10.3390/biomedicines10082009
104. D. G. Mercurio, T. A. Wagemaker, V. M. Alves, C. Benevenuto, L. R. Gaspar, P. M. Maia Campos (2015). In vivo photoprotective effects of cosmetic formulations containing UV filters, vitamins, Ginkgo biloba and red algae extracts.. Journal of photochemistry and photobiology. B, Biology, 153,
     121-6 . Link: 10.1016/j.jphotobiol.2015.09.016
105. Vincenzo Nobile, Andrea Burioli, Sara Yu, Shi Zhifeng, Enza Cestone, Violetta Insolia, Vincenzo Zaccaria, G. Malfa (2022). Photoprotective and Antiaging Effects of a Standardized Red Orange (Citrus sinensis (L.) Osbeck) Extract in Asian and Caucasian Subjects: A Randomized, Double-Blind, Controlled Study. Nutrients, 14, . Link: 10.3390/nu14112241
106. R. Bosch, N. Philips, J. A. Suárez-Pérez, Á. Juarranz, Avani Devmurari, Jovinna Chalensouk-Khaosaat, S. González (2015). Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals. Antioxidants, 4, 248 - 268. Link: 10.3390/antiox4020248
107. Ana Cristina Mellinas, A. Jiménez, M. C. Garrigós (2020). Pectin-Based Films with Cocoa Bean Shell Waste Extract and ZnO/Zn-NPs with Enhanced Oxygen Barrier, Ultraviolet Screen and Photocatalytic Properties. Foods, 9, . Link: 10.3390/foods9111572
108. Utin Variantini, Safruddin Amin, Anni Adriani, I. J. Ganda, G. Alam, M. H. Cangara (2016). The Protection Effect of Topical Cocoa Extract on Cyclobutane Pyrimidine Dimer (CPD) Formation and Tissue Neutrophil in Mice Induced by Ultraviolet B. American Journal of Clinical and Experimental Medicine, 4, 160. Link: 10.11648/J.AJCEM.20160406.11
109. H. Yoon, J. Kim, G. Y. Park, Jong-Eun Kim, Dong Hun Lee, K. Lee, J. Chung (2016). Cocoa Flavanol Supplementation Influences Skin Conditions of Photo-Aged Women: A 24-Week Double-Blind, Randomized, Controlled Trial.. The Journal of nutrition, 146 1,
     46-50 . Link: 10.3945/jn.115.217711
110. U. Heinrich, K. Neukam, H. Tronnier, H. Sies, W. Stahl (2006). Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women.. The Journal of nutrition, 136 6,
     1565-9 . Link: 10.1093/JN/136.6.1565
111. Jong-Eun Kim, Dasom Song, Junil Kim, Jina Choi, J. Kim, H. Yoon, Jung-Soo Bae, Mira Han, Sein Lee, Jiyoun Hong, Dayoung Song, S. Kim, M. Son, Sang-Woon Choi, J. Chung, Tae‐Aug Kim, K. Lee (2016). Oral Supplementation with Cocoa Extract Reduces UVB-Induced Wrinkles in Hairless Mouse Skin.. The Journal of investigative dermatology, 136 5,
     1012-1021 . Link: 10.1016/j.jid.2015.11.032
112. P. Gasser, E. Lati, L. Peno-Mazzarino, D. Bouzoud, L. Allegaert, H. Bernaert (2008). Cocoa polyphenols and their influence on parameters involved in ex vivo skin restructuring. International Journal of Cosmetic Science, 30, . Link: 10.1111/j.1468-2494.2008.00457.x
113. H. Yoon, J. Kim, G. Y. Park, Jong-Eun Kim, Dong Hun Lee, K. Lee, J. Chung (2016). Cocoa Flavanol Supplementation Influences Skin Conditions of Photo-Aged Women: A 24-Week Double-Blind, Randomized, Controlled Trial.. The Journal of nutrition, 146 1,
     46-50 . Link: 10.3945/jn.115.217711
114. Nor Mazlina Abdul Wahab (2020). Down regulation of Matrix Metalloproteinase-1 (MMP-1) and In Vivo skin efficacy by PBC140 Malaysian Cocoa Bean Extract. Journal of Nutritional Disorders & Therapy, , 3-3. Link:
115. G. Scapagnini, S. Davinelli, L. Di Renzo, A. De Lorenzo, Héctor Hugo Olarte, G. Micali, A. Cicero, S. González (2014). Cocoa Bioactive Compounds: Significance and Potential for the Maintenance of Skin Health. Nutrients, 6, 3202 - 3213. Link: 10.3390/nu6083202
116. J. A. Mogollon, C. Boivin, S. Lemieux, C. Blanchet, J. Claveau, S. Dodin (2014). Chocolate flavanols and skin photoprotection: a parallel, double-blind, randomized clinical trial. Nutrition Journal, 13, 66 - 66. Link: 10.1186/1475-2891-13-66
117. U. Heinrich, K. Neukam, H. Tronnier, H. Sies, W. Stahl (2006). Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women.. The Journal of nutrition, 136 6,
     1565-9 . Link: 10.1093/JN/136.6.1565
118. Catalina Agudelo, K. Bravo, A. Ramírez-Atehortúa, David Torres, Luis Carrillo-Hormaza, E. Osorio (2021). Chemical and Skincare Property Characterization of the Main Cocoa Byproducts: Extraction Optimization by RSM Approach for Development of Sustainable Ingredients. Molecules, 26, . Link: 10.3390/molecules26247429
119. L. B. Garcia, Gabriela A. Pires, D. A. Oliveira, Lorena A.O. Silva, A. Gomes, J. G. Amaral, G. Pereira, A. L. Ruela (2021). Incorporation of glycolic extract of cocoa beans (Theobroma cacao L.) into microemulsions and emulgels for skincare. Industrial Crops and Products, 161, 113181. Link: 10.1016/j.indcrop.2020.113181
120. K. Lee, J. Kundu, S. O. Kim, K. Chun, H. Lee, Y. Surh (2006). Cocoa polyphenols inhibit phorbol ester-induced superoxide anion formation in cultured HL-60 cells and expression of cyclooxygenase-2 and activation of NF-kappaB and MAPKs in mouse skin in vivo.. The Journal of nutrition, 136 5,
     1150-5 . Link: 10.1093/JN/136.5.1150