Science Corner 09 | Dr. Mark Hyman's Functional Approach to Aging
At SuppCo, we are revolutionizing how health experts share their personal supplementation strategies through the launch of our new Expert Protocols feature. This is not just another list of random supplements—it is your exclusive window into the methodical approaches of leading health innovators who combine scientific evidence with cutting-edge prevention strategies.
Dr. Mark Hyman stands at the forefront of this revolution. As a renowned physician, 15-time NYT bestselling author, Chief Medical Officer and co-founder of Function Health, and new SuppCo advisor, he is transforming personalized medicine. His Essential Longevity Protocol perfectly embodies his functional medicine philosophy, combining established essentials with next-generation compounds that target the fundamental mechanisms of aging.
The ingredients in Dr. Hyman's stack represent the frontier of longevity science, with numerous compounds mainstream supplementation has yet to fully embrace. While research continues to evolve, each nutrient offers compelling biological potential that you need to understand now, rather than years from now when they become commonplace.
Six Powerhouse Compounds Reshaping how we view Longevity
NMN: The Precursor to Mitochondrial Sparkplug NAD+
Cellular energy, repair, and resilience all rely on one molecule: NAD+. As we age, NAD+ levels decline, compromising mitochondrial function, metabolic flexibility, and cellular repair mechanisms. Boosting NAD+ is a core strategy in modern longevity science.
Research indicates that NAD+ precursors like NMN (Nicotinamide mononucleotide) help:
Restore youthful NAD+ levels
Enhance mitochondrial energy production
Support DNA repair and cellular resilience
Improve cognitive and metabolic function
Dr. Hyman’recommends NMN and even takes it in his personal stack. Users may also want to consider nicotinamide riboside,another popular NAD+ precursor with similar performance typically known as NR.
Urolithin A: The Mitochondrial Rejuvenator
Your mitochondria determine how you age. Period. Urolithin A represents a breakthrough in mitochondrial health through its activation of mitophagy—the critical cleanup process that removes damaged mitochondria and maintains cellular energy production.
Unlike direct supplementation, urolithin A is a postbiotic compound produced when gut bacteria process certain polyphenols from foods like pomegranates. Its potential benefits include:
Enhanced muscle function preservation during aging
Improved cellular energy production
Better metabolic efficiency
Reduced age-related inflammation
When your mitochondria function optimally, aging slows measurably. This is not theory—this is bioenergetic reality.
Quercetin: The Senescence Modulator
Cellular senescence (cell death) is a root cause of aging. Quercetin, a flavonoid found in onions, apples, and capers, helps modulate the inflammatory load of aging by targeting senescent cells and calming oxidative stress.
But that’s not all; research suggests quercetin helps:
Reduce oxidative damage and inflammation
Promote the clearance of senescent cells
Support immune balance and resilience
Synergize with other senolytics like fisetin
By addressing cellular “junk,” quercetin helps restore youthful cellular dynamics from the inside out.
Rutin: The Vascular Defender
Vascular health determines organ function across your entire body. Rutin, a flavonoid found in buckwheat and citrus, provides multidimensional support for your circulatory system while potentially acting as a senolytic—helping clear out zombie cells that drive aging.
Research highlights rutin's ability to:
Strengthen blood vessel integrity
Improve endothelial function
Target and eliminate senescent cells
Reduce systemic oxidative stress
Your vascular system is the highway for nutrient delivery—keeping it optimized is fundamental to longevity.
Fisetin: The Senolytic Specialist
Cellular senescence drives systemic aging. Fisetin, derived primarily from strawberries, represents one of the most promising natural senolytics—compounds that selectively eliminate dysfunctional senescent cells.
This powerful polyphenol works to:
Clear senescent cells that promote inflammation
Restore tissue function
Reduce age-related disease risk
Support cellular resilience
The accumulation of senescent cells is a primary driver of aging—addressing this process directly is revolutionary rather than incremental.
Astaxanthin: The Membrane Protector
This powerful red antioxidant does what ordinary antioxidants cannot—it integrates directly into cell membranes, creating a formidable defense against oxidative damage. Astaxanthin works at the cellular level to:
Enhance mitochondrial function and energy production
Support cardiovascular system integrity
Protect skin and eyes from environmental stress
Boost endurance capacity and recovery
Research indicates astaxanthin is 6,000 times more potent than vitamin C for certain antioxidant actions—making it a non-negotiable component for serious longevity strategies.
The Future of Aging Is Actionable Now
These compounds represent the forward-thinking approach that defines Dr. Hyman's philosophy. And now you have access to the same evidence-informed strategies used by leading health innovators.
At SuppCo, we balance cutting-edge approaches with scientific rigor. As research evolves, we continuously refine our recommendations, ensuring you benefit from the most current understanding of longevity science without waiting decades for conventional wisdom to catch up.
Take control of your aging process now. Explore Dr. Mark Hyman's complete longevity protocols on SuppCo and transform how you approach the biology of aging—because aging better is not about luck. It is about strategy.
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Personal note from Jordan
I am profoundly grateful to live in an era where cutting-edge expertise and rigorous academic science converge to enhance our health. People like Mark Hyman expand what is possible, while traditional research validates our path forward. I continuously evolve my own expertise by learning from these pioneers. For me, the truth about optimal health is crystal clear: isolation breeds limitation. When forward-thinking experts and methodical researchers collaborate, we all gain access to transformative solutions. Your health journey deserves this powerful combination of innovation and evidence… excellence never happens in a vacuum.